MSeqDR Mitochondrial disease browser phenotype pathogenic gene and mutation portal

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

*:HP: HPO terms, ND: NAMDC terms.
Most Studied CPEO, Complex I Deficiency, COXPD1, Leigh, LHON, MELAS, MERRF, NARP, SANDO

Disease Browser
Parent Node: systemic disease (MONDO:0015938)
..Starting node ..postorgasmic illness syndrome ()
Child Nodes:
Sister Nodes:
..amyloidosis (disease) ()
..calciphylaxis ()
..capillary leak syndrome ()
..connective tissue disorder due to lysyl hydroxylase-3 deficiency ()
..Ehlers-Danlos syndrome ()
..hereditary hemorrhagic telangiectasia ()
..hypoplasminogenemia ()
..Kikuchi-Fujimoto disease ()
..Kimura disease ()
..Langerhans cell histiocytosis ()
..macrophage activation syndrome ()
..malignant atrophic papulosis ()
..Marfan and Marfan-related disorder ()
..myalgia-eosinophilia syndrome associated with tryptophan ()
..non-Langerhans cell histiocytosis ()
..postorgasmic illness syndrome ()
..progeroid and marfanoid aspect-lipodystrophy syndrome ()
..retinal ischemic syndrome-digestive tract small vessel hyalinosis-diffuse cerebral calcifications syndrome ()
..Reye syndrome ()
..rheumatic fever ()
..sarcoidosis ()
..systemic autoimmune disease ()
..systemic disease with cataract ()
..systemic disease with skin involvement ()
..systemic diseases with anterior uveitis ()
..systemic diseases with panuveitis ()
..systemic diseases with posterior uveitis ()
..TAFRO syndrome ()
..tempi syndrome ()
..unexplained long-lasting fever/inflammatory syndrome ()
..X-linked reticulate pigmentary disorder ()
MONDO is developed by the Monarch Initiative. Human Disease MESH is developed by UMLS. Further data from MedGen, OMIM,ClinVar, CTD

Term ID:	17213
Name:	postorgasmic illness syndrome
Definition:	Postorgasmic illness syndrome (POIS) is a rare condition in which a man develops flu-like symptoms after ejaculation (when semen is released from the penis). Specific symptoms can include extreme fatigue, weakness, feverishness or sweating, mood changes or irritability, memory or concentration problems, and/or a stuffy nose or itching eyes. Symptoms may occur within seconds, minutes, or a few hours after ejaculation. Most symptoms last for 2 to 7 days and go away on their own. The underlying cause of POIS is poorly understood. Some scientists believe it may be due to a semen allergy that causes an immediate hypersensitivity reaction. There is no standard treatment for POIS, but some men have been treated with SSRIs , antihistamines , and/or benzodiazepines . Hyposensitization therapy (decreasing the immune response by exposure to semen) reportedly improved symptoms in two men with POIS.
Alternative IDs:
ParentIDs:
TreeNumbers:
Synonyms:	POIS; post orgasmic sick syndrome
Slim Mappings:
Reference:	MedGen: MeSH: OMIM: MSeqDR : Genes:
Phenotypes
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