Term ID: | 15545 |
Name: | macrophage activation syndrome |
Definition: | A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms. |
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Synonyms: | MAS; reactive hemophagocytic lymphohistiocytosis |
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MedGen:
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OMIM: MSeqDR : Genes: |
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Disease Causing ClinVar Variants | |
MSeqDR Portal | |