The Leigh Map
Leigh Map (https://www.vmh.life/#leighmap) is a novel gene-to-phenotype interaction network which can be used as a diagnostic resource for Leigh syndrome (IEMBASE000422; MIM 256000), one of the most frequently observed mitochondrial disorders. The user interface of Leigh Map is similar to Google Maps, whereby the user can zoom in to view increasingly detailed components and query elements of the map.
In Leigh Map, causative Leigh syndrome genes are arranged according to mitochondrial location and function. Zooming in will reveal icons for genes in their individual compartments.
Clicking on a gene icon will display inheritance information, patient demographics, and links to external databases. Clicking on a submap associated with a gene will display all HPO phenotypes associated with that particular gene defect.