Human Phenotype Ontology 
Grandparent Node:
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Abnormal eye physiology (HP:0012373)help
Parent Node:
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Lacrimation abnormality (HP:0000632)help
..Starting node
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Decreased lacrimation (HP:0000633)help
Term ID: 633
Name: Decreased lacrimation
Synonym: Decreased tear secretion
Definition: Abnormally decreased lacrimation, that is, reduced ability to produce tears.
Comments:
Reference: HP:0000633
Genes and Diseases:
 
       Child Nodes:
........expandAlacrima (HP:0000522) help

 Sister Nodes: 
..expandEpiphora (HP:0009926) help
..expandGustatory lacrimation (HP:0100274) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000633HP:0000633Decreased lacrimation0ERCC6 CL E G H2074133540Cockayne syndrome B133540C0751038OMIM11408153438609413
HP:0000633HP:0000633Decreased lacrimation0ERCC8 CL E G H1161216400Cockayne syndrome type A216400C0751039OMIM1703093439609412
HP:0000633HP:0000633Decreased lacrimation0SOX10 CL E G H6663163746ORPHA115123611190602229
HP:0000633HP:0000633Decreased lacrimation1ERCC6 CL E G H2074133540Cockayne syndrome B133540C0751038OMIM11408153438609413
HP:0000633HP:0000633Decreased lacrimation1ERCC8 CL E G H1161216400Cockayne syndrome type A216400C0751039OMIM1703093439609412
HP:0000633HP:0000633Decreased lacrimation1SOX10 CL E G H6663163746ORPHA115123611190602229
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000633HP:0000633Decreased lacrimation0ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM027243450605420
HP:0000633HP:0000633Decreased lacrimation1ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM027243450605420


Genes (15) :AAAS ALX4 DST ELP1 ERCC6 ERCC8 FGF10 FGFR2 FGFR3 GMPPA NGLY1 PAX1 SETBP1 SOX10 TRAPPC11

Diseases (15) :613451 133540 216400 163746 231550 614653 1764 223900 149730 615510 615273 615560 798 609136 615356
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.