Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal eye physiology (HP:0012373)

Parent Node:
Lacrimation abnormality (HP:0000632)

..Starting node
..Epiphora (HP:0009926)

Term ID:

9926

Name:

Epiphora

Synonym:

Increased lacrimation; Increased tears; Tearing; Watery eyes

Definition:

Abnormally increased lacrimation, that is, excessive tearing (watering eye).

Comments:

Reference:

HP:0009926

Genes and Diseases:

Child Nodes:

........

Increased tear production (HP:0031731)

................... HP:0031732 Increased basal tear production
................... HP:0031733 Reflex tearing

........

Lacrimal pump failure (HP:0031734)

........

Decreased tear drainage (HP:0031881)

Sister Nodes:

Decreased lacrimation (HP:0000633)

Gustatory lacrimation (HP:0100274)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0009926	HP:0009926	Epiphora	0	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0009926	Epiphora	0	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0009926	Epiphora	0	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0009926	Epiphora	0	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0009926	Epiphora	0	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0009926	Epiphora	0	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0009926	Epiphora	0	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0009926	Epiphora	0	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0009926	Epiphora	0	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0009926	Epiphora	0	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0009926	Epiphora	0	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0009926	Epiphora	0	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0009926	Epiphora	0	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0009926	Epiphora	0	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0009926	Epiphora	0	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0009926	Epiphora	0	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0009926	Epiphora	0	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0009926	Epiphora	0	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0009926	Epiphora	0	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0009926	Epiphora	0	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0009926	Epiphora	0	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HP:0009926	HP:0031734	Lacrimal pump failure	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0031881	Decreased tear drainage	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0031734	Lacrimal pump failure	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0031881	Decreased tear drainage	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0031731	Increased tear production	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0031731	Increased tear production	1	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0031731	Increased tear production	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0031731	Increased tear production	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0031881	Decreased tear drainage	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0031734	Lacrimal pump failure	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0031881	Decreased tear drainage	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0031734	Lacrimal pump failure	1	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0031731	Increased tear production	1	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0031881	Decreased tear drainage	1	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0031734	Lacrimal pump failure	1	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0031731	Increased tear production	1	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0031881	Decreased tear drainage	1	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0031734	Lacrimal pump failure	1	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0031731	Increased tear production	1	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0031881	Decreased tear drainage	1	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0031734	Lacrimal pump failure	1	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0031731	Increased tear production	1	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0031881	Decreased tear drainage	1	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0031734	Lacrimal pump failure	1	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0031731	Increased tear production	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0031731	Increased tear production	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0031881	Decreased tear drainage	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0031734	Lacrimal pump failure	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0031881	Decreased tear drainage	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0031734	Lacrimal pump failure	1	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0031881	Decreased tear drainage	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0031734	Lacrimal pump failure	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0031881	Decreased tear drainage	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0031734	Lacrimal pump failure	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0031731	Increased tear production	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0031731	Increased tear production	1	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0031731	Increased tear production	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0031731	Increased tear production	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0031734	Lacrimal pump failure	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0031881	Decreased tear drainage	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0031734	Lacrimal pump failure	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0031881	Decreased tear drainage	1	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0031731	Increased tear production	1	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0031734	Lacrimal pump failure	1	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0031881	Decreased tear drainage	1	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0031734	Lacrimal pump failure	1	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0031881	Decreased tear drainage	1	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0031734	Lacrimal pump failure	1	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0031881	Decreased tear drainage	1	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0031731	Increased tear production	1	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0031731	Increased tear production	1	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0031881	Decreased tear drainage	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0031734	Lacrimal pump failure	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0031881	Decreased tear drainage	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0031734	Lacrimal pump failure	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0031731	Increased tear production	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0031731	Increased tear production	1	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0031881	Decreased tear drainage	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0031734	Lacrimal pump failure	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0031734	Lacrimal pump failure	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HP:0009926	HP:0031881	Decreased tear drainage	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HP:0009926	HP:0031731	Increased tear production	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0031731	Increased tear production	1	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HP:0009926	HP:0031732	Increased basal tear production	2	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0031732	Increased basal tear production	2	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0031733	Reflex tearing	2	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	406	2194	113811
HP:0009926	HP:0031733	Reflex tearing	2	COL17A1 CL E G H	1308	122400	Epithelial recurrent erosion dystrophy	122400	C1852551	OMIM	1	392	2194	113811
HP:0009926	HP:0031733	Reflex tearing	2	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0031733	Reflex tearing	2	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0031732	Increased basal tear production	2	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	426	2890	300126
HP:0009926	HP:0031732	Increased basal tear production	2	DKC1 CL E G H	1736	305000	Dyskeratosis congenita X-linked	305000	C1148551	OMIM	1	396	2890	300126
HP:0009926	HP:0031733	Reflex tearing	2	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0031732	Increased basal tear production	2	IGSF3 CL E G H	3321	149700	Lacrimal duct defect	149700	C1835612	OMIM	1	22	5950	603491
HP:0009926	HP:0031733	Reflex tearing	2	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0031732	Increased basal tear production	2	KRT12 CL E G H	3859	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	38	6414	601687
HP:0009926	HP:0031733	Reflex tearing	2	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0031732	Increased basal tear production	2	KRT3 CL E G H	3850	122100	Meesman's corneal dystrophy	122100	C0339277	OMIM	1	28	6440	148043
HP:0009926	HP:0031733	Reflex tearing	2	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0031732	Increased basal tear production	2	LRP1 CL E G H	4035	604093	Keratosis pilaris	604093	C0263383	OMIM	1	164	6692	107770
HP:0009926	HP:0031733	Reflex tearing	2	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0031733	Reflex tearing	2	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0031732	Increased basal tear production	2	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	136	14377	606470
HP:0009926	HP:0031732	Increased basal tear production	2	NHP2 CL E G H	55651	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	113	14377	606470
HP:0009926	HP:0031732	Increased basal tear production	2	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0031732	Increased basal tear production	2	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0031733	Reflex tearing	2	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	676	16400	606416
HP:0009926	HP:0031733	Reflex tearing	2	NLRP3 CL E G H	114548	148200	Keratitis fugax hereditaria	148200	C1835697	OMIM	1	605	16400	606416
HP:0009926	HP:0031733	Reflex tearing	2	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0031733	Reflex tearing	2	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0031732	Increased basal tear production	2	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	88	14378	606471
HP:0009926	HP:0031732	Increased basal tear production	2	NOP10 CL E G H	55505	224230	Dyskeratosis congenita autosomal recessive 1	224230	C1857144	OMIM	1	80	14378	606471
HP:0009926	HP:0031733	Reflex tearing	2	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0031732	Increased basal tear production	2	OVOL2 CL E G H	58495	122000	Posterior polymorphous corneal dystrophy 1	122000	CN029625	OMIM	1	31	15804	616441
HP:0009926	HP:0031732	Increased basal tear production	2	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0031732	Increased basal tear production	2	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0031733	Reflex tearing	2	PLG CL E G H	5340	97231				ORPHA	1	165	9071	173350
HP:0009926	HP:0031733	Reflex tearing	2	PLG CL E G H	5340	97231				ORPHA	1	159	9071	173350
HP:0009926	HP:0031732	Increased basal tear production	2	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0031732	Increased basal tear production	2	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0031733	Reflex tearing	2	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	323	10729	607292
HP:0009926	HP:0031733	Reflex tearing	2	SEMA4A CL E G H	64218	610283	Cone-rod dystrophy 10	610283	C1846529	OMIM	1	240	10729	607292
HP:0009926	HP:0031732	Increased basal tear production	2	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0031732	Increased basal tear production	2	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HP:0009926	HP:0031733	Reflex tearing	2	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	288	11824	604319
HP:0009926	HP:0031733	Reflex tearing	2	TINF2 CL E G H	26277	613990	Dyskeratosis congenita, autosomal dominant, 3	613990	C3151445	OMIM	1	230	11824	604319
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009926	HP:0009926	Epiphora	0	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0009926	Epiphora	0	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0009926	Epiphora	0	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0009926	Epiphora	0	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736
HP:0009926	HP:0031881	Decreased tear drainage	1	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0031734	Lacrimal pump failure	1	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0031881	Decreased tear drainage	1	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0031734	Lacrimal pump failure	1	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0031731	Increased tear production	1	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0031731	Increased tear production	1	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0031881	Decreased tear drainage	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0031734	Lacrimal pump failure	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0031881	Decreased tear drainage	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736
HP:0009926	HP:0031734	Lacrimal pump failure	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736
HP:0009926	HP:0031731	Increased tear production	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0031731	Increased tear production	1	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736
HP:0009926	HP:0031732	Increased basal tear production	2	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0031732	Increased basal tear production	2	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0031733	Reflex tearing	2	SDHD CL E G H	6392	100093				ORPHA	0	507	10683	602690
HP:0009926	HP:0031733	Reflex tearing	2	SDHD CL E G H	6392	100093				ORPHA	0	442	10683	602690
HP:0009926	HP:0031732	Increased basal tear production	2	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0031732	Increased basal tear production	2	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736
HP:0009926	HP:0031733	Reflex tearing	2	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	151	20858	608736
HP:0009926	HP:0031733	Reflex tearing	2	SLC39A14 CL E G H	23516	144755	Hyperostosis cranialis interna	144755	C1840404	OMIM	0	136	20858	608736

Genes (15) :COL17A1 DKC1 IGSF3 KRT12 KRT3 LRP1 NHP2 NLRP3 NOP10 OVOL2 PLG SDHD SEMA4A SLC39A14 TINF2

Diseases (13) :122400 305000 149700 122100 604093 224230 148200 122000 97231 100093 610283 144755 613990

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.

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