Human Phenotype Ontology 
Grandparent Node:
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Abnormal eye physiology (HP:0012373)help
Parent Node:
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Lacrimation abnormality (HP:0000632)help
..Starting node
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Epiphora (HP:0009926)help
Term ID: 9926
Name: Epiphora
Synonym: Increased lacrimation; Increased tears; Tearing; Watery eyes
Definition: Abnormally increased lacrimation, that is, excessive tearing (watering eye).
Comments:
Reference: HP:0009926
Genes and Diseases:
 
       Child Nodes:
........expandIncreased tear production (HP:0031731) help
................... HP:0031732 Increased basal tear production
................... HP:0031733 Reflex tearing
........expandLacrimal pump failure (HP:0031734) help
........expandDecreased tear drainage (HP:0031881) help

 Sister Nodes: 
..expandDecreased lacrimation (HP:0000633) help
..expandGustatory lacrimation (HP:0100274) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0009926HP:0009926Epiphora0COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM11142592194113811
HP:0009926HP:0009926Epiphora0DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM1753222890300126
HP:0009926HP:0009926Epiphora0IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM12215950603491
HP:0009926HP:0009926Epiphora0KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM125356414601687
HP:0009926HP:0009926Epiphora0KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM14266440148043
HP:0009926HP:0009926Epiphora0LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM1271036692107770
HP:0009926HP:0009926Epiphora0NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM139214377606470
HP:0009926HP:0009926Epiphora0NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM114248816400606416
HP:0009926HP:0009926Epiphora0NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM116014378606471
HP:0009926HP:0009926Epiphora0OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM142815804616441
HP:0009926HP:0009926Epiphora0PLG CL E G H534097231ORPHA178859071173350
HP:0009926HP:0009926Epiphora0SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM11714010729607292
HP:0009926HP:0009926Epiphora0TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM14216511824604319
HP:0009926HP:0009926Epiphora1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM11142592194113811
HP:0009926HP:0009926Epiphora1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM1753222890300126
HP:0009926HP:0009926Epiphora1IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM12215950603491
HP:0009926HP:0009926Epiphora1KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM125356414601687
HP:0009926HP:0009926Epiphora1KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM14266440148043
HP:0009926HP:0009926Epiphora1LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM1271036692107770
HP:0009926HP:0009926Epiphora1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM139214377606470
HP:0009926HP:0009926Epiphora1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM114248816400606416
HP:0009926HP:0009926Epiphora1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM116014378606471
HP:0009926HP:0009926Epiphora1OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM142815804616441
HP:0009926HP:0009926Epiphora1PLG CL E G H534097231ORPHA178859071173350
HP:0009926HP:0009926Epiphora1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM11714010729607292
HP:0009926HP:0009926Epiphora1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM14216511824604319
HP:0009926HP:0009926Epiphora2COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM11142592194113811
HP:0009926HP:0009926Epiphora2DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM1753222890300126
HP:0009926HP:0009926Epiphora2IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM12215950603491
HP:0009926HP:0009926Epiphora2KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM125356414601687
HP:0009926HP:0009926Epiphora2KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM14266440148043
HP:0009926HP:0009926Epiphora2LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM1271036692107770
HP:0009926HP:0009926Epiphora2NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM139214377606470
HP:0009926HP:0009926Epiphora2NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM114248816400606416
HP:0009926HP:0009926Epiphora2NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM116014378606471
HP:0009926HP:0009926Epiphora2OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM142815804616441
HP:0009926HP:0009926Epiphora2PLG CL E G H534097231ORPHA178859071173350
HP:0009926HP:0009926Epiphora2SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM11714010729607292
HP:0009926HP:0009926Epiphora2TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM14216511824604319
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009926HP:0009926Epiphora0SDHD CL E G H6392100093ORPHA017436110683602690
HP:0009926HP:0009926Epiphora0SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM0910320858608736
HP:0009926HP:0009926Epiphora1SDHD CL E G H6392100093ORPHA017436110683602690
HP:0009926HP:0009926Epiphora1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM0910320858608736
HP:0009926HP:0009926Epiphora2SDHD CL E G H6392100093ORPHA017436110683602690
HP:0009926HP:0009926Epiphora2SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM0910320858608736


Genes (15) :COL17A1 DKC1 IGSF3 KRT12 KRT3 LRP1 NHP2 NLRP3 NOP10 OVOL2 PLG SDHD SEMA4A SLC39A14 TINF2

Diseases (13) :122400 305000 149700 122100 604093 224230 148200 122000 97231 100093 610283 144755 613990
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.