Human Phenotype Ontology 
Grandparent Node:
expand
Abnormal eye physiology (HP:0012373)help
Parent Node:
expand
Lacrimation abnormality (HP:0000632)help
..Starting node
..expand
Epiphora (HP:0009926)help
Term ID: 9926
Name: Epiphora
Synonym: Increased lacrimation; Increased tears; Tearing; Watery eyes
Definition: Abnormally increased lacrimation, that is, excessive tearing (watering eye).
Comments:
Reference: HP:0009926
Genes and Diseases:
 
       Child Nodes:
........expandIncreased tear production (HP:0031731) help
................... HP:0031732 Increased basal tear production
................... HP:0031733 Reflex tearing
........expandLacrimal pump failure (HP:0031734) help
........expandDecreased tear drainage (HP:0031881) help

 Sister Nodes: 
..expandDecreased lacrimation (HP:0000633) help
..expandGustatory lacrimation (HP:0100274) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0009926HP:0009926Epiphora0COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0009926Epiphora0COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0009926Epiphora0DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0009926Epiphora0DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0009926Epiphora0IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0009926Epiphora0KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0009926Epiphora0KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0009926Epiphora0LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0009926Epiphora0NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0009926Epiphora0NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0009926Epiphora0NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0009926Epiphora0NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0009926Epiphora0NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0009926Epiphora0NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0009926Epiphora0OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0009926Epiphora0PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0009926Epiphora0PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0009926Epiphora0SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0009926Epiphora0SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0009926Epiphora0TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0009926Epiphora0TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
HP:0009926HP:0031734Lacrimal pump failure1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0031881Decreased tear drainage1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0031734Lacrimal pump failure1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0031881Decreased tear drainage1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0031731Increased tear production1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0031731Increased tear production1COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0031731Increased tear production1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0031731Increased tear production1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0031881Decreased tear drainage1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0031734Lacrimal pump failure1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0031881Decreased tear drainage1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0031734Lacrimal pump failure1DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0031731Increased tear production1IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0031881Decreased tear drainage1IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0031734Lacrimal pump failure1IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0031731Increased tear production1KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0031881Decreased tear drainage1KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0031734Lacrimal pump failure1KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0031731Increased tear production1KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0031881Decreased tear drainage1KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0031734Lacrimal pump failure1KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0031731Increased tear production1LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0031881Decreased tear drainage1LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0031734Lacrimal pump failure1LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0031731Increased tear production1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0031731Increased tear production1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0031881Decreased tear drainage1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0031734Lacrimal pump failure1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0031881Decreased tear drainage1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0031734Lacrimal pump failure1NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0031881Decreased tear drainage1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0031734Lacrimal pump failure1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0031881Decreased tear drainage1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0031734Lacrimal pump failure1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0031731Increased tear production1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0031731Increased tear production1NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0031731Increased tear production1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0031731Increased tear production1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0031734Lacrimal pump failure1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0031881Decreased tear drainage1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0031734Lacrimal pump failure1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0031881Decreased tear drainage1NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0031731Increased tear production1OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0031734Lacrimal pump failure1OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0031881Decreased tear drainage1OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0031734Lacrimal pump failure1PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0031881Decreased tear drainage1PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0031734Lacrimal pump failure1PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0031881Decreased tear drainage1PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0031731Increased tear production1PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0031731Increased tear production1PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0031881Decreased tear drainage1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0031734Lacrimal pump failure1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0031881Decreased tear drainage1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0031734Lacrimal pump failure1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0031731Increased tear production1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0031731Increased tear production1SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0031881Decreased tear drainage1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0031734Lacrimal pump failure1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0031734Lacrimal pump failure1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
HP:0009926HP:0031881Decreased tear drainage1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
HP:0009926HP:0031731Increased tear production1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0031731Increased tear production1TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
HP:0009926HP:0031732Increased basal tear production2COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0031732Increased basal tear production2COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0031733Reflex tearing2COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM14062194113811
HP:0009926HP:0031733Reflex tearing2COL17A1 CL E G H1308122400Epithelial recurrent erosion dystrophy122400C1852551OMIM13922194113811
HP:0009926HP:0031733Reflex tearing2DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0031733Reflex tearing2DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0031732Increased basal tear production2DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM14262890300126
HP:0009926HP:0031732Increased basal tear production2DKC1 CL E G H1736305000Dyskeratosis congenita X-linked305000C1148551OMIM13962890300126
HP:0009926HP:0031733Reflex tearing2IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0031732Increased basal tear production2IGSF3 CL E G H3321149700Lacrimal duct defect149700C1835612OMIM1225950603491
HP:0009926HP:0031733Reflex tearing2KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0031732Increased basal tear production2KRT12 CL E G H3859122100Meesman's corneal dystrophy122100C0339277OMIM1386414601687
HP:0009926HP:0031733Reflex tearing2KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0031732Increased basal tear production2KRT3 CL E G H3850122100Meesman's corneal dystrophy122100C0339277OMIM1286440148043
HP:0009926HP:0031733Reflex tearing2LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0031732Increased basal tear production2LRP1 CL E G H4035604093Keratosis pilaris604093C0263383OMIM11646692107770
HP:0009926HP:0031733Reflex tearing2NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0031733Reflex tearing2NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0031732Increased basal tear production2NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM113614377606470
HP:0009926HP:0031732Increased basal tear production2NHP2 CL E G H55651224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM111314377606470
HP:0009926HP:0031732Increased basal tear production2NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0031732Increased basal tear production2NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0031733Reflex tearing2NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM167616400606416
HP:0009926HP:0031733Reflex tearing2NLRP3 CL E G H114548148200Keratitis fugax hereditaria148200C1835697OMIM160516400606416
HP:0009926HP:0031733Reflex tearing2NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0031733Reflex tearing2NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0031732Increased basal tear production2NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18814378606471
HP:0009926HP:0031732Increased basal tear production2NOP10 CL E G H55505224230Dyskeratosis congenita autosomal recessive 1224230C1857144OMIM18014378606471
HP:0009926HP:0031733Reflex tearing2OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0031732Increased basal tear production2OVOL2 CL E G H58495122000Posterior polymorphous corneal dystrophy 1122000CN029625OMIM13115804616441
HP:0009926HP:0031732Increased basal tear production2PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0031732Increased basal tear production2PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0031733Reflex tearing2PLG CL E G H534097231ORPHA11659071173350
HP:0009926HP:0031733Reflex tearing2PLG CL E G H534097231ORPHA11599071173350
HP:0009926HP:0031732Increased basal tear production2SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0031732Increased basal tear production2SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0031733Reflex tearing2SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM132310729607292
HP:0009926HP:0031733Reflex tearing2SEMA4A CL E G H64218610283Cone-rod dystrophy 10610283C1846529OMIM124010729607292
HP:0009926HP:0031732Increased basal tear production2TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0031732Increased basal tear production2TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
HP:0009926HP:0031733Reflex tearing2TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM128811824604319
HP:0009926HP:0031733Reflex tearing2TINF2 CL E G H26277613990Dyskeratosis congenita, autosomal dominant, 3613990C3151445OMIM123011824604319
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009926HP:0009926Epiphora0SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0009926Epiphora0SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0009926Epiphora0SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0009926Epiphora0SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736
HP:0009926HP:0031881Decreased tear drainage1SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0031734Lacrimal pump failure1SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0031881Decreased tear drainage1SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0031734Lacrimal pump failure1SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0031731Increased tear production1SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0031731Increased tear production1SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0031881Decreased tear drainage1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0031734Lacrimal pump failure1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0031881Decreased tear drainage1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736
HP:0009926HP:0031734Lacrimal pump failure1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736
HP:0009926HP:0031731Increased tear production1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0031731Increased tear production1SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736
HP:0009926HP:0031732Increased basal tear production2SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0031732Increased basal tear production2SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0031733Reflex tearing2SDHD CL E G H6392100093ORPHA050710683602690
HP:0009926HP:0031733Reflex tearing2SDHD CL E G H6392100093ORPHA044210683602690
HP:0009926HP:0031732Increased basal tear production2SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0031732Increased basal tear production2SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736
HP:0009926HP:0031733Reflex tearing2SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM015120858608736
HP:0009926HP:0031733Reflex tearing2SLC39A14 CL E G H23516144755Hyperostosis cranialis interna144755C1840404OMIM013620858608736


Genes (15) :COL17A1 DKC1 IGSF3 KRT12 KRT3 LRP1 NHP2 NLRP3 NOP10 OVOL2 PLG SDHD SEMA4A SLC39A14 TINF2

Diseases (13) :122400 305000 149700 122100 604093 224230 148200 122000 97231 100093 610283 144755 613990
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.