Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of the mouth (HP:0000153)

Parent Node:
Abnormal oral physiology (HP:0031815)

..Starting node
..Halitosis (HP:0100812)

Term ID:

100812

Name:

Halitosis

Synonym:

Bad breath; Foetor ex ore

Definition:

Noticeably unpleasant odors exhaled in breathing.

Comments:

Reference:

HP:0100812

Genes and Diseases:

Child Nodes:

Sister Nodes:

Abnormality of salivation (HP:0100755)

Impaired mastication (HP:0005216)

Oral bleeding (HP:0040184)

Oral cavity bleeding (HP:0030140)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0100812	HP:0100812	Halitosis	0	CFTR CL E G H	1080	1884	ORPHA:60033	Idiopathic bronchiectasis	HP:0040283 - Occasional	1371
HP:0100812	HP:0100812	Halitosis	0	MAT1A CL E G H	4143	6903	OMIM:250850	METHIONINE ADENOSYLTRANSFERASE I/III DEFICIENCY	.	82
HP:0100812	HP:0100812	Halitosis	0	SCNN1A CL E G H	6337	10599	ORPHA:60033	Idiopathic bronchiectasis	HP:0040283 - Occasional	67
HP:0100812	HP:0100812	Halitosis	0	SCNN1B CL E G H	6338	10600	ORPHA:60033	Idiopathic bronchiectasis	HP:0040283 - Occasional	61
HP:0100812	HP:0100812	Halitosis	0	SCNN1G CL E G H	6340	10602	ORPHA:60033	Idiopathic bronchiectasis	HP:0040283 - Occasional	57
HP:0100812	HP:0100812	Halitosis	0	SELENBP1 CL E G H	8991	10719	OMIM:618148	Extraoral halitosis due to MTO deficiency	.
HP:0100812	HP:0032142	Fetor hepaticus	1	CL E G H

Genes (6) :CFTR MAT1A SCNN1A SCNN1B SCNN1G SELENBP1

Diseases (3) :ORPHA:60033 OMIM:250850 OMIM:618148

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.