Human Phenotype Ontology 
Grandparent Node:
expandAbnormality of vitamin metabolism (HP:0100508)help
Parent Node:
expandAbnormality of vitamin K metabolism (HP:0100831)help
..Starting node
..expandIncreased PIVKA-II (HP:0045063)help
Term ID: 45063
Name: Increased PIVKA-II
Synonym: Increased prothrombin induced by vitamin K absence-II
Definition: Des-gamma carboxyprothrombin (DCP) or pro-thrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of patients with HCC. Generation of DCP is thought to be a result of an acquired defect in the post- translational carboxylation of the prothrombin precursor in malignant cells.
Comments:
Reference: HP:0045063
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandLow levels of vitamin K (HP:0011892) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0045063HP:0045063Increased PIVKA-II0 CL E G H


Genes (0) :

Diseases (0) :
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.