Human Phenotype Ontology 
Grandparent Node:
expandAbnormality of the coagulation cascade (HP:0003256)help
Parent Node:
expandAbnormality of the common coagulation pathway (HP:0010990)help
..Starting node
..expandReduced alpha-2-antiplasmin activity (HP:0040245)help
Term ID: 40245
Name: Reduced alpha-2-antiplasmin activity
Synonym:
Definition: Reduced activity of alpha-2-antiplasmin. This protein inactivates the protease plasmin that drives fibrinolysis.
Comments:
Reference: HP:0040245
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal coagulation factor V activity (HP:0031899) help
..expandAbnormality of circulating fibrinogen (HP:0011898) help
..expandDecreased level of heparin co-factor II (HP:0040226) help
..expandDecreased level of histidine-rich glycoprotein (HP:0040227) help
..expandDecreased level of plasminogen (HP:0040228) help
..expandDecreased level of thrombomodulin (HP:0040229) help
..expandDecreased level of tissue plasminogen activator (HP:0040230) help
..expandIncreased plasma vitamin K epoxide after vitamin K supplementation (HP:0040239) help
..expandProlonged Russell's viper venom time (HP:0040244) help
..expandReduced antithrombin antigen (HP:0040246) help
..expandReduced factor X activity (HP:0008321) help
..expandReduced factor XIII activity (HP:0008357) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0040245HP:0040245Reduced alpha-2-antiplasmin activity0SERPINE1 CL E G H50548583ORPHA:465Congenital plasminogen activator inhibitor type 1 deficiencyHP:0040281 - Very frequent39


Genes (1) :SERPINE1

Diseases (1) :ORPHA:465
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.