Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

..Starting node
..Lupus nephritis (HP:0033726)

Term ID:

33726

Name:

Lupus nephritis

Synonym:

Definition:

Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management.

Comments:

Reference:

HP:0033726

Genes and Diseases:

Child Nodes:

Sister Nodes:

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0033726	HP:0033726	Lupus nephritis	0	CTLA4 CL E G H	1493	2505	OMIM:152700	Systemic lupus erythematosus	10
HP:0033726	HP:0033726	Lupus nephritis	0	DNASE1 CL E G H	1773	2956	OMIM:152700	Systemic lupus erythematosus	3
HP:0033726	HP:0033726	Lupus nephritis	0	DNASE1L3 CL E G H	1776	2959	OMIM:614420	Systemic lupus erythematosus 16	3
HP:0033726	HP:0033726	Lupus nephritis	0	FCGR2A CL E G H	2212	3616	OMIM:152700	Systemic lupus erythematosus	6
HP:0033726	HP:0033726	Lupus nephritis	0	FCGR2B CL E G H	2213	3618	OMIM:152700	Systemic lupus erythematosus	2
HP:0033726	HP:0033726	Lupus nephritis	0	PTPN22 CL E G H	26191	9652	OMIM:152700	Systemic lupus erythematosus	3
HP:0033726	HP:0033726	Lupus nephritis	0	TREX1 CL E G H	11277	12269	OMIM:152700	Systemic lupus erythematosus	56
HP:0033726	HP:0033728	Mesangial proliferative lupus nephritis	1	CL E G H
HP:0033726	HP:0033727	Diffuse lupus nephritis	1	CL E G H
HP:0033726	HP:0033732	Advanced sclerotic lupus nephritis	1	CL E G H
HP:0033726	HP:0033731	Focal lupus nephritis	1	CL E G H
HP:0033726	HP:0033730	Membranous lupus nephritis	1	CL E G H
HP:0033726	HP:0033729	Minimal mesangial lupus nephritis	1	CL E G H

Genes (7) :CTLA4 DNASE1 DNASE1L3 FCGR2A FCGR2B PTPN22 TREX1

Diseases (2) :OMIM:152700 OMIM:614420

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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