Human Phenotype Ontology 
..Starting node
..expandDecreased proportion of CD4-positive T cells (HP:0032218)help
Term ID: 32218
Name: Decreased proportion of CD4-positive T cells
Synonym: Decreased proportion of CD4+ cells; Decreased proportion of CD4-positive, alpha-beta T cells; Reduced proportion of CD4-positive cells
Definition: A reduction in the proportion of CD4-positive T cells relative to the total number of T cells.
Comments:
Reference: HP:0032218
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0ATM CL E G H472795OMIM:208900ATAXIA-TELANGIECTASIA3267
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0ATP6AP2 CL E G H1015918305OMIM:301045CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIr; CDG2R36
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0BLM CL E G H6411058ORPHA:125Bloom syndromeHP:0040282 - Frequent314
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0CASP10 CL E G H8431500ORPHA:3261Autoimmune lymphoproliferative syndrome87
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0CD4 CL E G H9201678OMIM:619238IMMUNODEFICIENCY 79; IMD791
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0CIITA CL E G H42617067ORPHA:572Immunodeficiency by defective expression of MHC class II118
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0DEF6 CL E G H506192760OMIM:619573IMMUNODEFICIENCY 87 AND AUTOIMMUNITY; IMD87
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0DOCK8 CL E G H8170419191OMIM:243700Hyper-Ige recurrent infection syndrome, autosomal recessive217
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0EPG5 CL E G H5772429331OMIM:242840Vici syndrome40
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0EXTL3 CL E G H21373518ORPHA:508533Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome3
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0FAS CL E G H35511920ORPHA:3261Autoimmune lymphoproliferative syndrome59
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0FASLG CL E G H35611936ORPHA:3261Autoimmune lymphoproliferative syndrome37
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0IKBKB CL E G H35515960OMIM:618204IMMUNODEFICIENCY 15A; IMD15A4
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0IL2RG CL E G H35616010OMIM:312863Combined immunodeficiency, X-linked48
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiency48
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0IL7R CL E G H35756024ORPHA:169154T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency94
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0ITK CL E G H37026171OMIM:613011LYMPHOPROLIFERATIVE SYNDROME 1; LPFS151
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0IVNS1ABP CL E G H1062516951OMIM:618969IMMUNODEFICIENCY 70; IMD70
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0KNSTRN CL E G H9041730767ORPHA:221139Combined immunodeficiency with faciooculoskeletal anomalies1
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0LAT CL E G H2704018874OMIM:617514Immunodeficiency 522
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0LCK CL E G H39326524OMIM:615758Immunodeficiency 221
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0LCP2 CL E G H39376529OMIM:619374IMMUNODEFICIENCY 81; IMD81
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0LEP CL E G H39526553ORPHA:66628Obesity due to congenital leptin deficiency47
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0LEPR CL E G H39536554ORPHA:179494Obesity due to leptin receptor gene deficiency46
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0MAGT1 CL E G H8406128880OMIM:300853IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN17
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0MYC CL E G H46097553ORPHA:543Burkitt lymphoma11
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0NSMCE3 CL E G H561607677OMIM:617241LUNG DISEASE, IMMUNODEFICIENCY, AND CHROMOSOME BREAKAGE SYNDROME; LICS2
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0PGM3 CL E G H52388907ORPHA:443811PGM3-CDG15
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0PIK3CD CL E G H52938977ORPHA:221139Combined immunodeficiency with faciooculoskeletal anomalies9
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0PRKCD CL E G H55809399ORPHA:3261Autoimmune lymphoproliferative syndrome10
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0RASGRP1 CL E G H101259878ORPHA:3261Autoimmune lymphoproliferative syndrome
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0RFX5 CL E G H59939986ORPHA:572Immunodeficiency by defective expression of MHC class II38
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0RFXANK CL E G H86259987ORPHA:572Immunodeficiency by defective expression of MHC class II26
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0RFXAP CL E G H59949988ORPHA:572Immunodeficiency by defective expression of MHC class II34
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0SASH3 CL E G H5444015975OMIM:3010821
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0TOM1 CL E G H1004311982OMIM:619510IMMUNODEFICIENCY 85 AND AUTOIMMUNITY; IMD85
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0UNC119 CL E G H909412565OMIM:615518IMMUNODEFICIENCY 13; IMD1330
HP:0032218HP:0032218Decreased proportion of CD4-positive T cells0WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome65
HP:0032218HP:0025624Reduced proportion of CD4+ effector memory T cells1 CL E G H
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1ATM CL E G H472795OMIM:208900ATAXIA-TELANGIECTASIA.3267
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1CASP10 CL E G H8431500ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional87
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1CIITA CL E G H42617067ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040282 - Frequent118
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1DOCK8 CL E G H8170419191OMIM:243700Hyper-Ige recurrent infection syndrome, autosomal recessive217
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1EPG5 CL E G H5772429331OMIM:242840Vici syndrome.40
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1EXTL3 CL E G H21373518ORPHA:508533Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndromeHP:0040283 - Occasional3
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1FAS CL E G H35511920ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional59
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1FASLG CL E G H35611936ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional37
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1IKBKB CL E G H35515960OMIM:618204IMMUNODEFICIENCY 15A; IMD15A4
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1IL2RG CL E G H35616010OMIM:312863Combined immunodeficiency, X-linked.48
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiencyHP:0040281 - Very frequent48
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1IL7R CL E G H35756024ORPHA:169154T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiencyHP:0040282 - Frequent94
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1ITK CL E G H37026171OMIM:613011LYMPHOPROLIFERATIVE SYNDROME 1; LPFS151
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1IVNS1ABP CL E G H1062516951OMIM:618969IMMUNODEFICIENCY 70; IMD70
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1KNSTRN CL E G H9041730767ORPHA:221139Combined immunodeficiency with faciooculoskeletal anomaliesHP:0040282 - Frequent1
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1LCK CL E G H39326524OMIM:615758Immunodeficiency 22.1
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1LEP CL E G H39526553ORPHA:66628Obesity due to congenital leptin deficiencyHP:0040281 - Very frequent47
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1LEPR CL E G H39536554ORPHA:179494Obesity due to leptin receptor gene deficiencyHP:0040281 - Very frequent46
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1MAGT1 CL E G H8406128880OMIM:300853IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN17
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1MYC CL E G H46097553ORPHA:543Burkitt lymphomaHP:0040283 - Occasional11
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1NSMCE3 CL E G H561607677OMIM:617241LUNG DISEASE, IMMUNODEFICIENCY, AND CHROMOSOME BREAKAGE SYNDROME; LICS2
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1PGM3 CL E G H52388907ORPHA:443811PGM3-CDGHP:0040281 - Very frequent15
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1PIK3CD CL E G H52938977ORPHA:221139Combined immunodeficiency with faciooculoskeletal anomaliesHP:0040282 - Frequent9
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1PRKCD CL E G H55809399ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional10
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1RASGRP1 CL E G H101259878ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1RFX5 CL E G H59939986ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040282 - Frequent38
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1RFXANK CL E G H86259987ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040282 - Frequent26
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1RFXAP CL E G H59949988ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040282 - Frequent34
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1SASH3 CL E G H5444015975OMIM:3010821
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1TOM1 CL E G H1004311982OMIM:619510IMMUNODEFICIENCY 85 AND AUTOIMMUNITY; IMD85
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1UNC119 CL E G H909412565OMIM:615518IMMUNODEFICIENCY 13; IMD1330
HP:0032218HP:0005407Decreased proportion of CD4-positive helper T cells1WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome65


Genes (37) :ATM ATP6AP2 BLM CASP10 CD4 CIITA DEF6 DOCK8 EPG5 EXTL3 FAS FASLG IKBKB IL2RG IL7R ITK IVNS1ABP KNSTRN LAT LCK LCP2 LEP LEPR MAGT1 MYC NSMCE3 PGM3 PIK3CD PRKCD RASGRP1 RFX5 RFXANK RFXAP SASH3 TOM1 UNC119 WAS

Diseases (31) :OMIM:208900 OMIM:301045 ORPHA:125 ORPHA:3261 OMIM:619238 ORPHA:572 OMIM:619573 OMIM:243700 OMIM:242840 ORPHA:508533 OMIM:618204 OMIM:312863 ORPHA:276 ORPHA:169154 OMIM:613011 OMIM:618969 ORPHA:221139 OMIM:617514 OMIM:615758 OMIM:619374 ORPHA:66628 ORPHA:179494 OMIM:300853 ORPHA:543 OMIM:617241 ORPHA:443811 OMIM:618534 OMIM:301082 OMIM:619510 OMIM:615518 OMIM:301000
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.