Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal T cell activation (HP:0410035)

Parent Node:
Abnormal CD25 upregulation upon TCR activation (HP:0031269)

..Starting node
..Decreased CD25 upregulation upon TCR activation (HP:0031270)

Term ID:

31270

Name:

Decreased CD25 upregulation upon TCR activation

Synonym:

Poor CD25 upregulation upon TCR activation; Reduced IL2RA upregulation upon TCR activation

Definition:

Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR).

Comments:

Reference:

HP:0031270

Genes and Diseases:

Child Nodes:

Sister Nodes:

Input	HPO ID	HPO term	Distance	Gene
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031270	HP:0031270	Decreased CD25 upregulation upon TCR activation	0	CL E G H

Genes (0) :

Diseases (0) :

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.