Human Phenotype Ontology 
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..expandAbnormal proportion of CD4+ effector memory cells (HP:0025623)help
Term ID: 25623
Name: Abnormal proportion of CD4+ effector memory cells
Synonym: Abnormal proportion of CD4-positive effector memory cells; Abnormal proportion of effector memory CD4-positive, alpha-beta T cells
Definition: An abnormal proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
Comments:
Reference: HP:0025623
Genes and Diseases:
 
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InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025623HP:0025623Abnormal proportion of CD4+ effector memory cells0 CL E G H
HP:0025623HP:0025625Elevated proportion of CD4+ effector memory T cells1 CL E G H
HP:0025623HP:0025624Reduced proportion of CD4+ effector memory T cells1 CL E G H


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Diseases (0) :
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.