Human Phenotype Ontology 
..Starting node
..expandDecreased proportion of CD4+CD25+ regulatory T cells (HP:0020113)help
Term ID: 20113
Name: Decreased proportion of CD4+CD25+ regulatory T cells
Synonym: Decreased proportion of CD4+CD25+ Treg cells; Reduced proportion of CD4+CD25+ regulatory T cells
Definition: An abnormally decreased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells.
Comments:
Reference: HP:0020113
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0020113HP:0020113Decreased proportion of CD4+CD25+ regulatory T cells0CARD11 CL E G H8443316393OMIM:615206Card11 immunodeficiency45
HP:0020113HP:0020113Decreased proportion of CD4+CD25+ regulatory T cells0CTNNBL1 CL E G H5625915879OMIM:619846
HP:0020113HP:0020113Decreased proportion of CD4+CD25+ regulatory T cells0IL2RA CL E G H35596008OMIM:606367IMMUNODEFICIENCY 41 WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY; IMD4165
HP:0020113HP:0020113Decreased proportion of CD4+CD25+ regulatory T cells0PIK3CG CL E G H52948978OMIM:619802IMMUNODEFICIENCY 97 WITH AUTOINFLAMMATION; IMD972


Genes (4) :CARD11 CTNNBL1 IL2RA PIK3CG

Diseases (4) :OMIM:615206 OMIM:619846 OMIM:606367 OMIM:619802
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.