Human Phenotype Ontology 
Grandparent Node:
expandAbnormal T cell count (HP:0011839)help
Parent Node:
expandAbnormal T cell subset distribution (HP:0025540)help
..Starting node
..expandIncreased proportion of HLA DR+ T cells (HP:0002853)help
Term ID: 2853
Name: Increased proportion of HLA DR+ T cells
Synonym:
Definition: An elevated proportion of T cells that express human leukocyte antigen (HLA)-DR. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation.
Comments:
Reference: HP:0002853
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal CD4:CD8 ratio (HP:0031394) help
..expandAbnormal proportion of CD4-positive T cells (HP:0031392) help
..expandAbnormal proportion of CD8-positive T cells (HP:0031393) help
..expandAbnormal proportion of double-negative alpha-beta regulatory T cell (HP:0031399) help
..expandAbnormal proportion of naive T cells (HP:0031396) help
..expandIncreased proportion of exhausted T cells (HP:0031514) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002853HP:0002853Increased proportion of HLA DR+ T cells0CASP10 CL E G H8431500OMIM:603909Autoimmune lymphoproliferative syndrome, type IIA.87
HP:0002853HP:0002853Increased proportion of HLA DR+ T cells0FAS CL E G H35511920OMIM:601859Autoimmune lymphoproliferative syndrome.59
HP:0002853HP:0002853Increased proportion of HLA DR+ T cells0FASLG CL E G H35611936OMIM:601859Autoimmune lymphoproliferative syndrome.37


Genes (3) :CASP10 FAS FASLG

Diseases (2) :OMIM:603909 OMIM:601859
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.