Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal lung morphology (HP:0002088)

Parent Node:
Abnormal pulmonary interstitial morphology (HP:0006530)

..Starting node
..Lymphocytic interstitial pneumonia (HP:0006527)

Term ID:

6527

Name:

Lymphocytic interstitial pneumonia

Synonym:

Lymphocytic interstitial pneumonitis; Lymphoid interstitial pneumonia; Lymphoid interstitial pneumonitis

Definition:

Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa.

Comments:

Reference:

HP:0006527

Genes and Diseases:

Child Nodes:

Sister Nodes:

Bronchiolitis obliterans (HP:0011946)

Bronchiolitis obliterans organizing pneumonia (HP:0011945)

Desquamative interstitial pneumonitis (HP:0005942)

Honeycomb lung (HP:0025175)

Interstitial pneumonitis (HP:0006515)

Intralobular interstitial thickening (HP:0025176)

Peribronchovascular interstitial thickening (HP:0025177)

Pulmonary interstitial high-resolution computed tomography abnormality (HP:0025389)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006527	HP:0006527	Lymphocytic interstitial pneumonia	0	HLA-DPB1 CL E G H	3115	4940	ORPHA:133	Chronic beryllium disease	HP:0040282 - Frequent	1
HP:0006527	HP:0006527	Lymphocytic interstitial pneumonia	0	IL2RB CL E G H	3560	6009	OMIM:618495	Immunodeficiency 63 with lymphoproliferation and autoimmunity
HP:0006527	HP:0006527	Lymphocytic interstitial pneumonia	0	STAT5B CL E G H	6777	11367	OMIM:245590	GROWTH HORMONE INSENSITIVITY WITH IMMUNODEFICIENCY		12

Genes (3) :HLA-DPB1 IL2RB STAT5B

Diseases (3) :ORPHA:133 OMIM:618495 OMIM:245590

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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