Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of immune system physiology (HP:0010978)

Parent Node:
Opportunistic infection (HP:0031690)

..Starting node
..Severe viral infection (HP:0031691)

Term ID:

31691

Name:

Severe viral infection

Synonym:

Definition:

An unusually severe viral infection.

Comments:

Reference:

HP:0031691

Genes and Diseases:

Child Nodes:

........

Severe cytomegalovirus infection (HP:0031692)

........

Severe Epstein Barr virus infection (HP:0031693)

........

Severe adenovirus infection (HP:0031694)

........

Severe parainfluenza infection (HP:0031695)

Sister Nodes:

Disseminated cryptosporidium infection (HP:0031699)

Disseminated viral infection (HP:0031696)

Invasive parasitic infection (HP:0031700)

obsolete Disseminated Bacillus Calmette-Guerin infection (HP:0031698)

Recurrent opportunistic infections (HP:0005390)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031691	HP:0031691	Severe viral infection	0	ADORA2A CL E G H	135	263	ORPHA:363549	Acute encephalopathy with biphasic seizures and late reduced diffusion	HP:0040282 - Frequent	1
HP:0031691	HP:0031691	Severe viral infection	0	BLM CL E G H	641	1058	ORPHA:125	Bloom syndrome		314
HP:0031691	HP:0031691	Severe viral infection	0	CD27 CL E G H	939	11922	OMIM:615122	Lymphoproliferative syndrome 2		4
HP:0031691	HP:0031691	Severe viral infection	0	CD70 CL E G H	970	11937	OMIM:618261	LYMPHOPROLIFERATIVE SYNDROME 3; LPFS3
HP:0031691	HP:0031691	Severe viral infection	0	CTPS1 CL E G H	1503	2519	OMIM:615897	IMMUNODEFICIENCY 24; IMD24		2
HP:0031691	HP:0031691	Severe viral infection	0	DEF6 CL E G H	50619	2760	OMIM:619573	IMMUNODEFICIENCY 87 AND AUTOIMMUNITY; IMD87
HP:0031691	HP:0031691	Severe viral infection	0	DNASE2 CL E G H	1777	2960	OMIM:619858
HP:0031691	HP:0031691	Severe viral infection	0	DOCK2 CL E G H	1794	2988	OMIM:616433	Immunodeficiency 40		6
HP:0031691	HP:0031691	Severe viral infection	0	FCGR3A CL E G H	2214	3619	OMIM:615707	Immunodeficiency 20		4
HP:0031691	HP:0031691	Severe viral infection	0	IKBKG CL E G H	8517	5961	OMIM:300291	ECTODERMAL DYSPLASIA AND IMMUNODEFICIENCY 1; EDAID1		52
HP:0031691	HP:0031691	Severe viral infection	0	IL2RA CL E G H	3559	6008	OMIM:606367	IMMUNODEFICIENCY 41 WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY; IMD41		65
HP:0031691	HP:0031691	Severe viral infection	0	IL2RB CL E G H	3560	6009	OMIM:618495	Immunodeficiency 63 with lymphoproliferation and autoimmunity
HP:0031691	HP:0031691	Severe viral infection	0	IRF7 CL E G H	3665	6122	OMIM:616345	Immunodeficiency 39		2
HP:0031691	HP:0031691	Severe viral infection	0	LAT CL E G H	27040	18874	OMIM:617514	Immunodeficiency 52		2
HP:0031691	HP:0031691	Severe viral infection	0	MAGT1 CL E G H	84061	28880	OMIM:300853	IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN		17
HP:0031691	HP:0031691	Severe viral infection	0	MCM10 CL E G H	55388	18043	OMIM:619313	IMMUNODEFICIENCY 80 WITH OR WITHOUT CONGENITAL CARDIOMYOPATHY; IMD80
HP:0031691	HP:0031691	Severe viral infection	0	PGM3 CL E G H	5238	8907	OMIM:615816	Immunodeficiency 23		15
HP:0031691	HP:0031691	Severe viral infection	0	PIK3R1 CL E G H	5295	8979	OMIM:616005	Immunodeficiency 36		43
HP:0031691	HP:0031691	Severe viral infection	0	RAC2 CL E G H	5880	9802	OMIM:618986	IMMUNODEFICIENCY 73B WITH DEFECTIVE NEUTROPHIL CHEMOTAXIS AND LYMPHOPENIA; IMD73B		9
HP:0031691	HP:0031691	Severe viral infection	0	REL CL E G H	5966	9954	OMIM:619652	IMMUNODEFICIENCY 92; IMD92		1
HP:0031691	HP:0031691	Severe viral infection	0	SASH3 CL E G H	54440	15975	OMIM:301082			1
HP:0031691	HP:0031691	Severe viral infection	0	SH2D1A CL E G H	4068	10820	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		37
HP:0031691	HP:0031691	Severe viral infection	0	STAT2 CL E G H	6773	11363	OMIM:616636	Immunodeficiency 44		9
HP:0031691	HP:0031691	Severe viral infection	0	TGFB1 CL E G H	7040	11766	OMIM:618213	INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY; IBDIMDE		13
HP:0031691	HP:0031691	Severe viral infection	0	TLR7 CL E G H	51284	15631	OMIM:301051	IMMUNODEFICIENCY 74, COVID19-RELATED, X-LINKED; IMD74
HP:0031691	HP:0031691	Severe viral infection	0	TPP2 CL E G H	7174	12016	OMIM:619220	IMMUNODEFICIENCY 78 WITH AUTOIMMUNITY AND DEVELOPMENTAL DELAY; IMD78
HP:0031691	HP:0031691	Severe viral infection	0	XIAP CL E G H	331	592	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		81
HP:0031691	HP:0031691	Severe viral infection	0	ZNFX1 CL E G H	57169	29271	OMIM:619644	IMMUNODEFICIENCY 91 AND HYPERINFLAMMATION; IMD91
HP:0031691	HP:0031695	Severe parainfluenza infection	1	CL E G H
HP:0031691	HP:0031694	Severe adenovirus infection	1	CL E G H
HP:0031691	HP:0032170	Severe varicella zoster infection	1	BLM CL E G H	641	1058	ORPHA:125	Bloom syndrome	HP:0040283 - Occasional	314
HP:0031691	HP:0032170	Severe varicella zoster infection	1	CD27 CL E G H	939	11922	OMIM:615122	Lymphoproliferative syndrome 2		4
HP:0031691	HP:0033508	EBV meningitis	1	CD27 CL E G H	939	11922	OMIM:615122	Lymphoproliferative syndrome 2		4
HP:0031691	HP:0032170	Severe varicella zoster infection	1	CD70 CL E G H	970	11937	OMIM:618261	LYMPHOPROLIFERATIVE SYNDROME 3; LPFS3
HP:0031691	HP:0032170	Severe varicella zoster infection	1	CTPS1 CL E G H	1503	2519	OMIM:615897	IMMUNODEFICIENCY 24; IMD24		2
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	DEF6 CL E G H	50619	2760	OMIM:619573	IMMUNODEFICIENCY 87 AND AUTOIMMUNITY; IMD87
HP:0031691	HP:0031693	Severe Epstein Barr virus infection	1	DNASE2 CL E G H	1777	2960	OMIM:619858
HP:0031691	HP:0032170	Severe varicella zoster infection	1	DOCK2 CL E G H	1794	2988	OMIM:616433	Immunodeficiency 40		6
HP:0031691	HP:0032170	Severe varicella zoster infection	1	FCGR3A CL E G H	2214	3619	OMIM:615707	Immunodeficiency 20		4
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	IKBKG CL E G H	8517	5961	OMIM:300291	ECTODERMAL DYSPLASIA AND IMMUNODEFICIENCY 1; EDAID1		52
HP:0031691	HP:0032170	Severe varicella zoster infection	1	IL2RA CL E G H	3559	6008	OMIM:606367	IMMUNODEFICIENCY 41 WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY; IMD41		65
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	IL2RB CL E G H	3560	6009	OMIM:618495	Immunodeficiency 63 with lymphoproliferation and autoimmunity
HP:0031691	HP:0034249	Severe influenza infection	1	IRF7 CL E G H	3665	6122	OMIM:616345	Immunodeficiency 39		2
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	LAT CL E G H	27040	18874	OMIM:617514	Immunodeficiency 52		2
HP:0031691	HP:0032170	Severe varicella zoster infection	1	MAGT1 CL E G H	84061	28880	OMIM:300853	IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN		17
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	MAGT1 CL E G H	84061	28880	OMIM:300853	IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN		17
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	MCM10 CL E G H	55388	18043	OMIM:619313	IMMUNODEFICIENCY 80 WITH OR WITHOUT CONGENITAL CARDIOMYOPATHY; IMD80
HP:0031691	HP:0032170	Severe varicella zoster infection	1	PGM3 CL E G H	5238	8907	OMIM:615816	Immunodeficiency 23		15
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	PIK3R1 CL E G H	5295	8979	OMIM:616005	Immunodeficiency 36		43
HP:0031691	HP:0032170	Severe varicella zoster infection	1	RAC2 CL E G H	5880	9802	OMIM:618986	IMMUNODEFICIENCY 73B WITH DEFECTIVE NEUTROPHIL CHEMOTAXIS AND LYMPHOPENIA; IMD73B		9
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	REL CL E G H	5966	9954	OMIM:619652	IMMUNODEFICIENCY 92; IMD92		1
HP:0031691	HP:0034249	Severe influenza infection	1	SASH3 CL E G H	54440	15975	OMIM:301082			1
HP:0031691	HP:0032170	Severe varicella zoster infection	1	SASH3 CL E G H	54440	15975	OMIM:301082			1
HP:0031691	HP:0031693	Severe Epstein Barr virus infection	1	SH2D1A CL E G H	4068	10820	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		37
HP:0031691	HP:0032170	Severe varicella zoster infection	1	TGFB1 CL E G H	7040	11766	OMIM:618213	INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY; IBDIMDE		13
HP:0031691	HP:0033141	Severe SARS-CoV-2 infection	1	TLR7 CL E G H	51284	15631	OMIM:301051	IMMUNODEFICIENCY 74, COVID19-RELATED, X-LINKED; IMD74
HP:0031691	HP:0031692	Severe cytomegalovirus infection	1	TPP2 CL E G H	7174	12016	OMIM:619220	IMMUNODEFICIENCY 78 WITH AUTOIMMUNITY AND DEVELOPMENTAL DELAY; IMD78
HP:0031691	HP:0031693	Severe Epstein Barr virus infection	1	XIAP CL E G H	331	592	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		81
HP:0031691	HP:0033431	Cytomegalovirus colitis	2	CL E G H
HP:0031691	HP:0032247	Persistent CMV viremia	2	IL2RB CL E G H	3560	6009	OMIM:618495	Immunodeficiency 63 with lymphoproliferation and autoimmunity
HP:0031691	HP:0032247	Persistent CMV viremia	2	LAT CL E G H	27040	18874	OMIM:617514	Immunodeficiency 52		2
HP:0031691	HP:0032247	Persistent CMV viremia	2	MAGT1 CL E G H	84061	28880	OMIM:300853	IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN		17
HP:0031691	HP:0032247	Persistent CMV viremia	2	PIK3R1 CL E G H	5295	8979	OMIM:616005	Immunodeficiency 36		43
HP:0031691	HP:0032247	Persistent CMV viremia	2	REL CL E G H	5966	9954	OMIM:619652	IMMUNODEFICIENCY 92; IMD92		1
HP:0031691	HP:0032247	Persistent CMV viremia	2	TPP2 CL E G H	7174	12016	OMIM:619220	IMMUNODEFICIENCY 78 WITH AUTOIMMUNITY AND DEVELOPMENTAL DELAY; IMD78

Genes (28) :ADORA2A BLM CD27 CD70 CTPS1 DEF6 DNASE2 DOCK2 FCGR3A IKBKG IL2RA IL2RB IRF7 LAT MAGT1 MCM10 PGM3 PIK3R1 RAC2 REL SASH3 SH2D1A STAT2 TGFB1 TLR7 TPP2 XIAP ZNFX1

Diseases (27) :ORPHA:363549 ORPHA:125 OMIM:615122 OMIM:618261 OMIM:615897 OMIM:619573 OMIM:619858 OMIM:616433 OMIM:615707 OMIM:300291 OMIM:606367 OMIM:618495 OMIM:616345 OMIM:617514 OMIM:300853 OMIM:619313 OMIM:615816 OMIM:616005 OMIM:618986 OMIM:619652 OMIM:301082 OMIM:308240 OMIM:616636 OMIM:618213 OMIM:301051 OMIM:619220 OMIM:619644

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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