Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of the anterior pituitary (HP:0011747)

Grandparent Node:
Neoplasm of the pituitary gland (HP:0040277)

Parent Node:
Neoplasm of the anterior pituitary (HP:0011750)

..Starting node
..Pituitary adenoma (HP:0002893)

Term ID:

2893

Name:

Pituitary adenoma

Synonym:

Noncancerous tumor in pituitary gland; Noncancerous tumour in pituitary gland; Pituitary gland adenoma

Definition:

A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary).

Comments:

Reference:

HP:0002893

Genes and Diseases:

Child Nodes:

........

Pituitary prolactin cell adenoma (HP:0006767)

................... HP:0012341 Microprolactinoma
................... HP:0012342 Macroprolactinoma

........

Pituitary corticotropic cell adenoma (HP:0008291)

........

Pituitary acidophilic stem cell adenoma (HP:0011758)

........

Pituitary gonadotropic cell adenoma (HP:0011759)

........

Pituitary growth hormone cell adenoma (HP:0011760)

........

Pituitary null cell adenoma (HP:0011761)

........

Pituitary thyrotropic cell adenoma (HP:0011762)

Sister Nodes:

Pituitary carcinoma (HP:0011763)

Pituitary spindle cell oncocytoma (HP:0011764)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002893	HP:0002893	Pituitary adenoma	0	AIP CL E G H	9049	358	ORPHA:963	Acromegaly		95
HP:0002893	HP:0002893	Pituitary adenoma	0	AIP CL E G H	9049	358	OMIM:219090	Pituitary adenoma 4, ACTH-secreting, somatic	.	95
HP:0002893	HP:0002893	Pituitary adenoma	0	AIP CL E G H	9049	358	OMIM:102200	Pituitary adenoma, growth hormone-secreting, 1	.	95
HP:0002893	HP:0002893	Pituitary adenoma	0	AIP CL E G H	9049	358	ORPHA:99725	Pituitary gigantism		95
HP:0002893	HP:0002893	Pituitary adenoma	0	ALG5 CL E G H	29880	20266	ORPHA:730	Autosomal dominant polycystic kidney disease
HP:0002893	HP:0002893	Pituitary adenoma	0	ALG9 CL E G H	79796	15672	ORPHA:730	Autosomal dominant polycystic kidney disease		93
HP:0002893	HP:0002893	Pituitary adenoma	0	APC CL E G H	324	583	ORPHA:99818	Turcot syndrome with polyposis	HP:0040284 - Very rare	3179
HP:0002893	HP:0002893	Pituitary adenoma	0	ARMC5 CL E G H	79798	25781	ORPHA:189427	Cushing syndrome due to macronodular adrenal hyperplasia		7
HP:0002893	HP:0002893	Pituitary adenoma	0	ATRX CL E G H	546	886	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	169
HP:0002893	HP:0002893	Pituitary adenoma	0	BICC1 CL E G H	80114	19351	ORPHA:730	Autosomal dominant polycystic kidney disease		5
HP:0002893	HP:0002893	Pituitary adenoma	0	BMPR1A CL E G H	657	1076	ORPHA:440437	Familial colorectal cancer Type X	HP:0040283 - Occasional	385
HP:0002893	HP:0002893	Pituitary adenoma	0	BRAF CL E G H	673	1097	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	276
HP:0002893	HP:0002893	Pituitary adenoma	0	CDH23 CL E G H	64072	13733	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	636
HP:0002893	HP:0002893	Pituitary adenoma	0	CDH23 CL E G H	64072	13733	OMIM:617540	Pituitary adenoma 5, multiple types	.	636
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	2
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	102
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040282 - Frequent	102
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN1B CL E G H	1027	1785	OMIM:610755	Multiple endocrine neoplasia, type IV	.	102
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	1
HP:0002893	HP:0002893	Pituitary adenoma	0	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent
HP:0002893	HP:0002893	Pituitary adenoma	0	DNAJB11 CL E G H	51726	14889	ORPHA:730	Autosomal dominant polycystic kidney disease
HP:0002893	HP:0002893	Pituitary adenoma	0	EPCAM CL E G H	4072	11529	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	170
HP:0002893	HP:0002893	Pituitary adenoma	0	FAN1 CL E G H	22909	29170	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	15
HP:0002893	HP:0002893	Pituitary adenoma	0	GANAB CL E G H	23193	4138	ORPHA:730	Autosomal dominant polycystic kidney disease		6
HP:0002893	HP:0002893	Pituitary adenoma	0	GNAS CL E G H	2778	4392	ORPHA:189427	Cushing syndrome due to macronodular adrenal hyperplasia		101
HP:0002893	HP:0002893	Pituitary adenoma	0	GNAS CL E G H	2778	4392	OMIM:174800	McCune-Albright syndrome, somatic, mosaic	.	101
HP:0002893	HP:0002893	Pituitary adenoma	0	GPR101 CL E G H	83550	14963	ORPHA:963	Acromegaly		5
HP:0002893	HP:0002893	Pituitary adenoma	0	GPR101 CL E G H	83550	14963	OMIM:300942	Chromosome Xq26.3 duplication syndrome		5
HP:0002893	HP:0002893	Pituitary adenoma	0	GPR101 CL E G H	83550	14963	OMIM:300943	PITUITARY ADENOMA 2, GROWTH HORMONE-SECRETING; PITA2		5
HP:0002893	HP:0002893	Pituitary adenoma	0	IDH1 CL E G H	3417	5382	ORPHA:163634	Maffucci syndrome	HP:0040283 - Occasional	15
HP:0002893	HP:0002893	Pituitary adenoma	0	IDH2 CL E G H	3418	5383	ORPHA:163634	Maffucci syndrome	HP:0040283 - Occasional	29
HP:0002893	HP:0002893	Pituitary adenoma	0	IFNG CL E G H	3458	5438	ORPHA:805	Tuberous sclerosis complex	HP:0040284 - Very rare	23
HP:0002893	HP:0002893	Pituitary adenoma	0	IFT140 CL E G H	9742	29077	ORPHA:730	Autosomal dominant polycystic kidney disease		148
HP:0002893	HP:0002893	Pituitary adenoma	0	KRAS CL E G H	3845	6407	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	196
HP:0002893	HP:0002893	Pituitary adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:97279	Insulinoma		462
HP:0002893	HP:0002893	Pituitary adenoma	0	MEN1 CL E G H	4221	7010	OMIM:131100	Multiple endocrine neoplasia 1		462
HP:0002893	HP:0002893	Pituitary adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	462
HP:0002893	HP:0002893	Pituitary adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:99725	Pituitary gigantism		462
HP:0002893	HP:0002893	Pituitary adenoma	0	MLH1 CL E G H	4292	7127	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	1819
HP:0002893	HP:0002893	Pituitary adenoma	0	MLH3 CL E G H	27030	7128	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	131
HP:0002893	HP:0002893	Pituitary adenoma	0	MSH2 CL E G H	4436	7325	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	2162
HP:0002893	HP:0002893	Pituitary adenoma	0	MSH6 CL E G H	2956	7329	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	2232
HP:0002893	HP:0002893	Pituitary adenoma	0	NR3C1 CL E G H	2908	7978	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	79
HP:0002893	HP:0002893	Pituitary adenoma	0	PDE11A CL E G H	50940	8773	ORPHA:1359	Carney complex	HP:0040282 - Frequent	13
HP:0002893	HP:0002893	Pituitary adenoma	0	PDE11A CL E G H	50940	8773	ORPHA:189439	Primary pigmented nodular adrenocortical disease		13
HP:0002893	HP:0002893	Pituitary adenoma	0	PDE8B CL E G H	8622	8794	ORPHA:189439	Primary pigmented nodular adrenocortical disease		75
HP:0002893	HP:0002893	Pituitary adenoma	0	PIK3CA CL E G H	5290	8975	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	162
HP:0002893	HP:0002893	Pituitary adenoma	0	PKD1 CL E G H	5310	9008	ORPHA:730	Autosomal dominant polycystic kidney disease		342
HP:0002893	HP:0002893	Pituitary adenoma	0	PKD2 CL E G H	5311	9009	ORPHA:730	Autosomal dominant polycystic kidney disease		106
HP:0002893	HP:0002893	Pituitary adenoma	0	PMS1 CL E G H	5378	9121	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	56
HP:0002893	HP:0002893	Pituitary adenoma	0	PMS2 CL E G H	5395	9122	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	1121
HP:0002893	HP:0002893	Pituitary adenoma	0	PRKACA CL E G H	5566	9380	ORPHA:189439	Primary pigmented nodular adrenocortical disease		2
HP:0002893	HP:0002893	Pituitary adenoma	0	PRKAR1A CL E G H	5573	9388	ORPHA:1359	Carney complex	HP:0040282 - Frequent	134
HP:0002893	HP:0002893	Pituitary adenoma	0	PRKAR1A CL E G H	5573	9388	OMIM:160980	Carney complex, type 1	.	134
HP:0002893	HP:0002893	Pituitary adenoma	0	PRKAR1A CL E G H	5573	9388	ORPHA:189439	Primary pigmented nodular adrenocortical disease		134
HP:0002893	HP:0002893	Pituitary adenoma	0	RPS20 CL E G H	6224	10405	ORPHA:440437	Familial colorectal cancer Type X	HP:0040283 - Occasional	1
HP:0002893	HP:0002893	Pituitary adenoma	0	SEMA4A CL E G H	64218	10729	ORPHA:440437	Familial colorectal cancer Type X	HP:0040283 - Occasional	48
HP:0002893	HP:0002893	Pituitary adenoma	0	TGFBR2 CL E G H	7048	11773	ORPHA:144	Lynch syndrome	HP:0040283 - Occasional	253
HP:0002893	HP:0002893	Pituitary adenoma	0	TP53 CL E G H	7157	11998	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	911
HP:0002893	HP:0002893	Pituitary adenoma	0	TSC1 CL E G H	7248	12362	ORPHA:805	Tuberous sclerosis complex	HP:0040284 - Very rare	1090
HP:0002893	HP:0002893	Pituitary adenoma	0	TSC2 CL E G H	7249	12363	ORPHA:805	Tuberous sclerosis complex	HP:0040284 - Very rare	2738
HP:0002893	HP:0002893	Pituitary adenoma	0	USP48 CL E G H	84196	18533	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	1
HP:0002893	HP:0002893	Pituitary adenoma	0	USP8 CL E G H	9101	12631	ORPHA:96253	Cushing disease	HP:0040281 - Very frequent	7
HP:0002893	HP:0002893	Pituitary adenoma	0	USP8 CL E G H	9101	12631	OMIM:219090	Pituitary adenoma 4, ACTH-secreting, somatic	.	7
HP:0002893	HP:0002893	Pituitary adenoma	0	YY1 CL E G H	7528	12856	ORPHA:97279	Insulinoma		7
HP:0002893	HP:0025694	Pituitary microadenoma	1	CL E G H
HP:0002893	HP:0025693	Pituitary macroadenoma	1	CL E G H
HP:0002893	HP:0011758	Pituitary acidophilic stem cell adenoma	1	CL E G H
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	AIP CL E G H	9049	358	ORPHA:963	Acromegaly	HP:0040281 - Very frequent	95
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	AIP CL E G H	9049	358	ORPHA:963	Acromegaly	HP:0040283 - Occasional	95
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	AIP CL E G H	9049	358	OMIM:102200	Pituitary adenoma, growth hormone-secreting, 1	.	95
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	AIP CL E G H	9049	358	OMIM:102200	Pituitary adenoma, growth hormone-secreting, 1	.	95
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	AIP CL E G H	9049	358	ORPHA:99725	Pituitary gigantism	HP:0040282 - Frequent	95
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	AIP CL E G H	9049	358	ORPHA:99725	Pituitary gigantism	HP:0040281 - Very frequent	95
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	ALG5 CL E G H	29880	20266	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	ALG9 CL E G H	79796	15672	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	93
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	ATRX CL E G H	546	886	ORPHA:96253	Cushing disease		169
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	BICC1 CL E G H	80114	19351	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	5
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	BRAF CL E G H	673	1097	ORPHA:96253	Cushing disease		276
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDH23 CL E G H	64072	13733	ORPHA:96253	Cushing disease		636
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	2
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	2
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	2
HP:0002893	HP:0011762	Pituitary thyrotropic cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	2
HP:0002893	HP:0011759	Pituitary gonadotropic cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	2
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040283 - Occasional	2
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	102
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040283 - Occasional	102
HP:0002893	HP:0011762	Pituitary thyrotropic cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	102
HP:0002893	HP:0011759	Pituitary gonadotropic cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	102
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	102
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	102
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040283 - Occasional	102
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040282 - Frequent	102
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040282 - Frequent	102
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040282 - Frequent	102
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	1
HP:0002893	HP:0011759	Pituitary gonadotropic cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	1
HP:0002893	HP:0011762	Pituitary thyrotropic cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	1
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	1
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	1
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040283 - Occasional	1
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare
HP:0002893	HP:0011759	Pituitary gonadotropic cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare
HP:0002893	HP:0011762	Pituitary thyrotropic cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040283 - Occasional
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	DNAJB11 CL E G H	51726	14889	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	GANAB CL E G H	23193	4138	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	6
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	GPR101 CL E G H	83550	14963	ORPHA:963	Acromegaly	HP:0040281 - Very frequent	5
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	GPR101 CL E G H	83550	14963	ORPHA:963	Acromegaly	HP:0040283 - Occasional	5
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	IFT140 CL E G H	9742	29077	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	148
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	462
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	MEN1 CL E G H	4221	7010	OMIM:131100	Multiple endocrine neoplasia 1	.	462
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	462
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040283 - Occasional	462
HP:0002893	HP:0011761	Pituitary null cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	462
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	462
HP:0002893	HP:0011762	Pituitary thyrotropic cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	462
HP:0002893	HP:0011759	Pituitary gonadotropic cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare	462
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:99725	Pituitary gigantism	HP:0040282 - Frequent	462
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	MEN1 CL E G H	4221	7010	ORPHA:99725	Pituitary gigantism	HP:0040281 - Very frequent	462
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	NR3C1 CL E G H	2908	7978	ORPHA:96253	Cushing disease		79
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	PDE11A CL E G H	50940	8773	ORPHA:1359	Carney complex	HP:0040282 - Frequent	13
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	PKD1 CL E G H	5310	9008	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	342
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	PKD2 CL E G H	5311	9009	ORPHA:730	Autosomal dominant polycystic kidney disease	HP:0040284 - Very rare	106
HP:0002893	HP:0011760	Pituitary growth hormone cell adenoma	1	PRKAR1A CL E G H	5573	9388	ORPHA:1359	Carney complex	HP:0040282 - Frequent	134
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	TP53 CL E G H	7157	11998	ORPHA:96253	Cushing disease		911
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	USP48 CL E G H	84196	18533	ORPHA:96253	Cushing disease		1
HP:0002893	HP:0008291	Pituitary corticotropic cell adenoma	1	USP8 CL E G H	9101	12631	ORPHA:96253	Cushing disease		7
HP:0002893	HP:0006767	Pituitary prolactin cell adenoma	1	YY1 CL E G H	7528	12856	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	7
HP:0002893	HP:0012342	Macroprolactinoma	2	CL E G H
HP:0002893	HP:0012341	Microprolactinoma	2	CL E G H

Genes (49) :AIP ALG5 ALG9 APC ARMC5 ATRX BICC1 BMPR1A BRAF CDH23 CDKN1A CDKN1B CDKN2B CDKN2C DNAJB11 EPCAM FAN1 GANAB GNAS GPR101 IDH1 IDH2 IFNG IFT140 KRAS MEN1 MLH1 MLH3 MSH2 MSH6 NR3C1 PDE11A PDE8B PIK3CA PKD1 PKD2 PMS1 PMS2 PRKACA PRKAR1A RPS20 SEMA4A TGFBR2 TP53 TSC1 TSC2 USP48 USP8 YY1

Diseases (24) :ORPHA:963 OMIM:219090 OMIM:102200 ORPHA:99725 ORPHA:730 ORPHA:99818 ORPHA:189427 ORPHA:96253 ORPHA:440437 OMIM:617540 ORPHA:652 ORPHA:276152 OMIM:610755 ORPHA:144 OMIM:174800 OMIM:300942 OMIM:300943 ORPHA:163634 ORPHA:805 ORPHA:97279 OMIM:131100 ORPHA:1359 ORPHA:189439 OMIM:160980

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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