Human Phenotype Ontology

About
MSeqDR-LSDB
Tools
- Quick-Mitome for WES
- Quick-Mitome
- Quick-Mitome Report
- mtDNA Tool:
- mvTool
- Phy-Mer
- MToolBox
- mvTool for Haplogroup
- mvTool with HmtDB
- MitoMaster
- MitoTIP tRNA Scoring
- MSeq-OpenCGA
- Variant Tool:
- VariantOneStop
- HBCR Exome (Retired)
- POLG Patho. Server
- Data - Awsomics GeEx
- Expert Panel
- Panel Tool:
- Gene Panel Examiner
- Transgenomic_NuclearMitome
- Pedigree Maker
- json2table
Phenome-Disease
Collaboration
- Genesis (GEM.App)
- LeighMap
- Expert Panel
- Collaboration Zone
Submission
- Submit_Interpret_Variant
- Instructions

Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Neoplasm of the anterior pituitary (HP:0011750)

Parent Node:
Pituitary adenoma (HP:0002893)

..Starting node
..Pituitary prolactin cell adenoma (HP:0006767)

Term ID:

6767

Name:

Pituitary prolactin cell adenoma

Synonym:

Pituitary prolactinoma; Prolactin-secreting pituitary adenoma

Definition:

A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women.

Comments:

Reference:

HP:0006767

Genes and Diseases:

Child Nodes:

........

Microprolactinoma (HP:0012341)

........

Macroprolactinoma (HP:0012342)

Sister Nodes:

Pituitary acidophilic stem cell adenoma (HP:0011758)

Pituitary corticotropic cell adenoma (HP:0008291)

Pituitary gonadotropic cell adenoma (HP:0011759)

Pituitary growth hormone cell adenoma (HP:0011760)

Pituitary null cell adenoma (HP:0011761)

Pituitary thyrotropic cell adenoma (HP:0011762)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	AIP CL E G H	9049	358	ORPHA:963	Acromegaly	HP:0040283 - Occasional	95
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	AIP CL E G H	9049	358	OMIM:102200	Pituitary adenoma, growth hormone-secreting, 1	.	95
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	AIP CL E G H	9049	358	ORPHA:99725	Pituitary gigantism	HP:0040282 - Frequent	95
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	2
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	102
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	CDKN1B CL E G H	1027	1785	ORPHA:276152	Multiple endocrine neoplasia type 4	HP:0040282 - Frequent	102
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	1
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	GPR101 CL E G H	83550	14963	ORPHA:963	Acromegaly	HP:0040283 - Occasional	5
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	462
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	MEN1 CL E G H	4221	7010	OMIM:131100	Multiple endocrine neoplasia 1	.	462
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040282 - Frequent	462
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	MEN1 CL E G H	4221	7010	ORPHA:99725	Pituitary gigantism	HP:0040282 - Frequent	462
HP:0006767	HP:0006767	Pituitary prolactin cell adenoma	0	YY1 CL E G H	7528	12856	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	7
HP:0006767	HP:0012341	Microprolactinoma	1	CL E G H
HP:0006767	HP:0012342	Macroprolactinoma	1	CL E G H

Genes (8) :AIP CDKN1A CDKN1B CDKN2B CDKN2C GPR101 MEN1 YY1

Diseases (7) :ORPHA:963 OMIM:102200 ORPHA:99725 ORPHA:652 ORPHA:276152 ORPHA:97279 OMIM:131100

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

Feedback about the webpages , or email to MSeqDR webmaster: Lishuang Shen