Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Impairment in personality functioning (HP:0031466)

Parent Node:
Abnormal fear/anxiety-related behavior (HP:0100852)

..Starting node
..Panic attack (HP:0025269)

Term ID:

25269

Name:

Panic attack

Synonym:

Panic attack

Definition:

A sudden episode of intense fear in a situation in which there is no danger or apparent cause.

Comments:

Reference:

HP:0025269

Genes and Diseases:

Child Nodes:

Sister Nodes:

Agoraphobia (HP:0000756)

Anxiety (HP:0000739)

Claustrophobia (HP:0025253)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025269	HP:0025269	Panic attack	0	ATRX CL E G H	546	886	ORPHA:96253	Cushing disease		169
HP:0025269	HP:0025269	Panic attack	0	BRAF CL E G H	673	1097	ORPHA:96253	Cushing disease		276
HP:0025269	HP:0025269	Panic attack	0	CDH23 CL E G H	64072	13733	ORPHA:96253	Cushing disease		636
HP:0025269	HP:0025269	Panic attack	0	CDKL5 CL E G H	6792	11411	ORPHA:3095	Atypical Rett syndrome	HP:0040283 - Occasional	405
HP:0025269	HP:0025269	Panic attack	0	CDKN2A CL E G H	1029	1787	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent	289
HP:0025269	HP:0025269	Panic attack	0	CIZ1 CL E G H	25792	16744	ORPHA:420492	Adult-onset cervical dystonia, DYT23 type	HP:0040283 - Occasional	16
HP:0025269	HP:0025269	Panic attack	0	CREBBP CL E G H	1387	2348	ORPHA:353281	Rubinstein-Taybi syndrome due to 16p13.3 microdeletion	HP:0040282 - Frequent	291
HP:0025269	HP:0025269	Panic attack	0	CREBBP CL E G H	1387	2348	ORPHA:353277	Rubinstein-Taybi syndrome due to CREBBP mutations	HP:0040282 - Frequent	291
HP:0025269	HP:0025269	Panic attack	0	CTNNB1 CL E G H	1499	2514	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent	88
HP:0025269	HP:0025269	Panic attack	0	DLST CL E G H	1743	2911	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional
HP:0025269	HP:0025269	Panic attack	0	DNAJC6 CL E G H	9829	15469	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	6
HP:0025269	HP:0025269	Panic attack	0	DNMT3A CL E G H	1788	2978	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	44
HP:0025269	HP:0025269	Panic attack	0	DRD2 CL E G H	1813	3023	ORPHA:36899	Myoclonus-dystonia syndrome	HP:0040282 - Frequent	16
HP:0025269	HP:0025269	Panic attack	0	EP300 CL E G H	2033	3373	ORPHA:353284	Rubinstein-Taybi syndrome due to EP300 haploinsufficiency	HP:0040282 - Frequent	250
HP:0025269	HP:0025269	Panic attack	0	EPAS1 CL E G H	2034	3374	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	112
HP:0025269	HP:0025269	Panic attack	0	FH CL E G H	2271	3700	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	301
HP:0025269	HP:0025269	Panic attack	0	GABBR2 CL E G H	9568	4507	ORPHA:3095	Atypical Rett syndrome	HP:0040283 - Occasional	5
HP:0025269	HP:0025269	Panic attack	0	HTRA2 CL E G H	27429	14348	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	39
HP:0025269	HP:0025269	Panic attack	0	KCNN2 CL E G H	3781	6291	OMIM:619725	NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT VARIABLE MOVEMENT OR BEHAVIORAL ABNORMALITIES; NEDMAB
HP:0025269	HP:0025269	Panic attack	0	KCTD17 CL E G H	79734	25705	ORPHA:36899	Myoclonus-dystonia syndrome	HP:0040282 - Frequent	1
HP:0025269	HP:0025269	Panic attack	0	KIF1B CL E G H	23095	16636	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	202
HP:0025269	HP:0025269	Panic attack	0	LRRK2 CL E G H	120892	18618	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	221
HP:0025269	HP:0025269	Panic attack	0	MAX CL E G H	4149	6913	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	84
HP:0025269	HP:0025269	Panic attack	0	MDH2 CL E G H	4191	6971	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	4
HP:0025269	HP:0025269	Panic attack	0	MECP2 CL E G H	4204	6990	ORPHA:3095	Atypical Rett syndrome	HP:0040283 - Occasional	950
HP:0025269	HP:0025269	Panic attack	0	NF1 CL E G H	4763	7765	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	1952
HP:0025269	HP:0025269	Panic attack	0	NR3C1 CL E G H	2908	7978	ORPHA:96253	Cushing disease		79
HP:0025269	HP:0025269	Panic attack	0	NTNG1 CL E G H	22854	23319	ORPHA:3095	Atypical Rett syndrome	HP:0040283 - Occasional	1
HP:0025269	HP:0025269	Panic attack	0	PARK7 CL E G H	11315	16369	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	23
HP:0025269	HP:0025269	Panic attack	0	PINK1 CL E G H	65018	14581	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	55
HP:0025269	HP:0025269	Panic attack	0	PODXL CL E G H	5420	9171	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	6
HP:0025269	HP:0025269	Panic attack	0	PRKAR1A CL E G H	5573	9388	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent	134
HP:0025269	HP:0025269	Panic attack	0	PRKN CL E G H	5071	8607	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	138
HP:0025269	HP:0025269	Panic attack	0	RET CL E G H	5979	9967	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	572
HP:0025269	HP:0025269	Panic attack	0	RET CL E G H	5979	9967	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	572
HP:0025269	HP:0025269	Panic attack	0	SDHA CL E G H	6389	10680	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	304
HP:0025269	HP:0025269	Panic attack	0	SDHAF2 CL E G H	54949	26034	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	55
HP:0025269	HP:0025269	Panic attack	0	SDHB CL E G H	6390	10681	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	237
HP:0025269	HP:0025269	Panic attack	0	SDHB CL E G H	6390	10681	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	237
HP:0025269	HP:0025269	Panic attack	0	SDHC CL E G H	6391	10682	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	147
HP:0025269	HP:0025269	Panic attack	0	SDHD CL E G H	6392	10683	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	129
HP:0025269	HP:0025269	Panic attack	0	SDHD CL E G H	6392	10683	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	129
HP:0025269	HP:0025269	Panic attack	0	SGCE CL E G H	8910	10808	ORPHA:36899	Myoclonus-dystonia syndrome	HP:0040282 - Frequent	49
HP:0025269	HP:0025269	Panic attack	0	SLC25A11 CL E G H	8402	10981	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional
HP:0025269	HP:0025269	Panic attack	0	SMC1A CL E G H	8243	11111	ORPHA:3095	Atypical Rett syndrome	HP:0040283 - Occasional	135
HP:0025269	HP:0025269	Panic attack	0	SNCA CL E G H	6622	11138	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	65
HP:0025269	HP:0025269	Panic attack	0	SPART CL E G H	23111	18514	ORPHA:101000	Autosomal recessive spastic paraplegia type 20	HP:0040283 - Occasional	66
HP:0025269	HP:0025269	Panic attack	0	SPECC1L CL E G H	23384	29022	OMIM:145420	Hypertelorism, Teebi type		6
HP:0025269	HP:0025269	Panic attack	0	SYNJ1 CL E G H	8867	11503	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	9
HP:0025269	HP:0025269	Panic attack	0	TERT CL E G H	7015	11730	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent	238
HP:0025269	HP:0025269	Panic attack	0	TMEM127 CL E G H	55654	26038	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	131
HP:0025269	HP:0025269	Panic attack	0	TOR1A CL E G H	1861	3098	ORPHA:36899	Myoclonus-dystonia syndrome	HP:0040282 - Frequent	47
HP:0025269	HP:0025269	Panic attack	0	TP53 CL E G H	7157	11998	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent	911
HP:0025269	HP:0025269	Panic attack	0	TP53 CL E G H	7157	11998	ORPHA:96253	Cushing disease		911
HP:0025269	HP:0025269	Panic attack	0	UCHL1 CL E G H	7345	12513	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	21
HP:0025269	HP:0025269	Panic attack	0	USP48 CL E G H	84196	18533	ORPHA:96253	Cushing disease		1
HP:0025269	HP:0025269	Panic attack	0	USP8 CL E G H	9101	12631	ORPHA:96253	Cushing disease		7
HP:0025269	HP:0025269	Panic attack	0	VHL CL E G H	7428	12687	ORPHA:29072	Hereditary pheochromocytoma-paraganglioma	HP:0040283 - Occasional	490
HP:0025269	HP:0025269	Panic attack	0	VHL CL E G H	7428	12687	ORPHA:276621	Sporadic pheochromocytoma/secreting paraganglioma	HP:0040283 - Occasional	490
HP:0025269	HP:0025269	Panic attack	0	VPS13C CL E G H	54832	23594	ORPHA:2828	Young-onset Parkinson disease	HP:0040283 - Occasional	8
HP:0025269	HP:0025269	Panic attack	0	ZNRF3 CL E G H	84133	18126	ORPHA:1501	Adrenocortical carcinoma	HP:0040282 - Frequent

Genes (55) :ATRX BRAF CDH23 CDKL5 CDKN2A CIZ1 CREBBP CTNNB1 DLST DNAJC6 DNMT3A DRD2 EP300 EPAS1 FH GABBR2 HTRA2 KCNN2 KCTD17 KIF1B LRRK2 MAX MDH2 MECP2 NF1 NR3C1 NTNG1 PARK7 PINK1 PODXL PRKAR1A PRKN RET SDHA SDHAF2 SDHB SDHC SDHD SGCE SLC25A11 SMC1A SNCA SPART SPECC1L SYNJ1 TERT TMEM127 TOR1A TP53 UCHL1 USP48 USP8 VHL VPS13C ZNRF3

Diseases (14) :ORPHA:96253 ORPHA:3095 ORPHA:1501 ORPHA:420492 ORPHA:353281 ORPHA:353277 ORPHA:29072 ORPHA:2828 ORPHA:276621 ORPHA:36899 ORPHA:353284 OMIM:619725 ORPHA:101000 OMIM:145420

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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