Human Phenotype Ontology 
Grandparent Node:
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Abnormality of toe (HP:0001780)help
Grandparent Node:
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Syndactyly (HP:0001159)help
Parent Node:
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Cutaneous syndactyly (HP:0012725)help
Parent Node:
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Toe syndactyly (HP:0001770)help
..Starting node
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Cutaneous syndactyly of toes (HP:0010621)help
Term ID: 10621
Name: Cutaneous syndactyly of toes
Synonym: Cutaneous syndactyly of feet; soft tissue syndactyly of toes; Webbed skin of toes
Definition: A soft tissue continuity in the anteroposterior axis between adjacent foot digits that involves at least half of the proximodistal length of one of the two involved digits; or, a soft tissue continuity in the A/P axis between two digits of the foot that does not meet the prior objective criteria.
Comments:
Reference: HP:0010621
Genes and Diseases:
 
       Child Nodes:
........expand2-3 toe cutaneous syndactyly (HP:0005709) help
........expand1-2 toe complete cutaneous syndactyly (HP:0005767) help
........expand2-4 toe cutaneous syndactyly (HP:0005768) help

 Sister Nodes: 
..expand1-2 toe syndactyly (HP:0010711) help
..expand1-3 toe syndactyly (HP:0001459) help
..expand1-4 toe syndactyly (HP:0010712) help
..expand1-5 toe syndactyly (HP:0010713) help
..expand2-3 toe syndactyly (HP:0004691) help
..expand2-4 toe syndactyly (HP:0010714) help
..expand2-5 toe syndactyly (HP:0010715) help
..expand3-4 toe syndactyly (HP:0009779) help
..expand3-5 toe syndactyly (HP:0010716) help
..expand4-5 toe syndactyly (HP:0004692) help
..expandOsseous syndactyly of toes (HP:0010717) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0010621HP:0010621Cutaneous syndactyly of toes0MYH8 CL E G H4626158300Hecht syndrome158300C0265226OMIM132257578160741
HP:0010621HP:0010621Cutaneous syndactyly of toes0NECTIN1 CL E G H5818225060Cleft lip/palate-ectodermal dysplasia syndrome225060C2931488OMIM1151959706600644
HP:0010621HP:0010621Cutaneous syndactyly of toes0NOG CL E G H9241611377Brachydactyly type B2611377C1969652OMIM164477866602991
HP:0010621HP:0010621Cutaneous syndactyly of toes1MYH8 CL E G H4626158300Hecht syndrome158300C0265226OMIM132257578160741
HP:0010621HP:0010621Cutaneous syndactyly of toes1NECTIN1 CL E G H5818225060Cleft lip/palate-ectodermal dysplasia syndrome225060C2931488OMIM1151959706600644
HP:0010621HP:0010621Cutaneous syndactyly of toes1NOG CL E G H9241611377Brachydactyly type B2611377C1969652OMIM164477866602991
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0010621HP:0010621Cutaneous syndactyly of toes0FGF9 CL E G H2254612961Multiple synostoses syndrome 3612961C2751826OMIM031463687600921
HP:0010621HP:0010621Cutaneous syndactyly of toes0SMARCAD1 CL E G H56916129200Basan syndrome129200C0406707OMIM023918398612761
HP:0010621HP:0010621Cutaneous syndactyly of toes0SMO CL E G H6608601707Craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development601707C0795915OMIM077111119601500
HP:0010621HP:0010621Cutaneous syndactyly of toes1FGF9 CL E G H2254612961Multiple synostoses syndrome 3612961C2751826OMIM031463687600921
HP:0010621HP:0010621Cutaneous syndactyly of toes1SMARCAD1 CL E G H56916129200Basan syndrome129200C0406707OMIM023918398612761
HP:0010621HP:0010621Cutaneous syndactyly of toes1SMO CL E G H6608601707Craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development601707C0795915OMIM077111119601500


Genes (9) :FGF9 GJA1 MCTP2 MYH8 NECTIN1 NECTIN4 NOG SMARCAD1 SMO

Diseases (9) :612961 158300 225060 611377 129200 601707 257850 1596 613573
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.