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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Disease Browser
Parent Node: Basal Ganglia Diseases (D001480)
Parent Node: Neurotoxicity Syndromes (D020258)
..Starting node ..Neuroleptic Malignant Syndrome (D009459)
Child Nodes:
Sister Nodes:
..Akathisia, Drug-Induced (D017109)
..Alcohol-Induced Disorders, Nervous System (D020268) 6
..Botulism (D001906)
..Dyskinesia, Drug-Induced (D004409)
..Heavy Metal Poisoning, Nervous System (D020260) 7
..MPTP Poisoning (D020267)
..Neuroleptic Malignant Syndrome (D009459)
Human Disease MESH is developed by UMLS. Further data from MedGen, OMIM, CTD

Term ID:	7971
Name:	Neuroleptic Malignant Syndrome
Definition:	A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Alternative IDs:
ParentIDs:	MESH:D001480\|MESH:D020258
TreeNumbers:	C10.228.140.079.737 \|C10.720.737 \|C25.723.705.600
Synonyms:	Neuroleptic Induced Neuroleptic Malignant Syndrome \|Neuroleptic-Induced Neuroleptic Malignant Syndrome \|Neuroleptic Malignant Syndrome, Neuroleptic Induced \|Neuroleptic-Malignant Syndrome, Neuroleptic Induced \|Neuroleptic Malignant Syndromes \|NMS (Neuroleptic
Slim Mappings:	Nervous system disease
Reference:	MedGen: D009459 MeSH: D009459 OMIM: Genes:
Phenotypes
Disease Causing ClinVar Variants