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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Disease Browser
Parent Node: Demyelinating Diseases (D003711)
Parent Node: Encephalitis, Viral (D018792)
Parent Node: Leukoencephalopathies (D056784)
Parent Node: Polyomavirus Infections (D027601)
Parent Node: Slow Virus Diseases (D012897)
..Starting node ..Leukoencephalopathy, Progressive Multifocal (D007968)
Child Nodes:
Sister Nodes:
..Acquired Immunodeficiency Syndrome (D000163)
..AIDS-Related Complex (D000386)
..Aleutian Mink Disease (D000453)
..Equine Infectious Anemia (D004859)
..Feline Acquired Immunodeficiency Syndrome (D016181)
..Leukoencephalopathy, Progressive Multifocal (D007968)
..Pneumonia, Progressive Interstitial, of Sheep (D011021)
..Simian Acquired Immunodeficiency Syndrome (D016097)
..Subacute Sclerosing Panencephalitis (D013344) 1
..Visna (D016182)
Human Disease MESH is developed by UMLS. Further data from MedGen, OMIM, CTD

Term ID:	6394
Name:	Leukoencephalopathy, Progressive Multifocal
Definition:	An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Alternative IDs:
ParentIDs:	MESH:D003711\|MESH:D012897\|MESH:D018792\|MESH:D027601\|MESH:D056784
TreeNumbers:	C02.182.500.300.500 \|C02.256.721.500 \|C02.290.575 \|C02.839.550 \|C10.228.140.695.750 \|C10.228.228.210.150.300.500 \|C10.228.228.245.340.575 \|C10.314.450
Synonyms:	Encephalitis, JC Polyomavirus \|Encephalopathies, JC Polyomavirus \|Encephalopathy, JC Polyomavirus \|JC Polyomavirus Encephalitis \|JC Polyomavirus Encephalopathy \|Leukoencephalopathies, Progressive Multifocal \|Multifocal Leukoencephalopathies, Progressive \|Multif
Slim Mappings:	Nervous system disease\|Viral disease
Reference:	MedGen: D007968 MeSH: D007968 OMIM: Genes:
Phenotypes
Disease Causing ClinVar Variants