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Term ID: | 6343 |
Name: | Leukemia, Large Granular Lymphocytic |
Definition: | A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. |
Alternative IDs: | |
ParentIDs: | MESH:D015458 |
TreeNumbers: | C04.557.337.428.580.049 |C15.604.515.560.575.049 |C20.683.515.528.582.049 |
Synonyms: | Large Granular Lymphocyte Leukemia |Leukemia, LGL |Leukemia, Lymphocytic, Large Granular |Leukemia, Natural Killer Cell Large Granular Lymphocytic |Leukemia, NK LGL |Leukemia, NK-LGL |Leukemias, LGL |Leukemias, NK-LGL |Leukemias, T-LGL |Leukemia, T Cell Large Gra |
Slim Mappings: | Cancer|Immune system disease|Lymphatic disease |
Reference: |
MedGen: D054066
MeSH: D054066
OMIM:
Genes: | Phenotypes | | Disease Causing ClinVar Variants | |
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