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Disease Browser
Parent Node:
expandKeratoderma, Palmoplantar (D007645)
..Starting node
..expandKeratoderma, Palmoplantar, Diffuse (D015776)

       Child Nodes:
........expandBeardwell syndrome (C537665)
........expandDiffuse palmoplantar keratoderma, Bothnian type (C536173)
........expandHyperkeratosis of the palms and soles and esophageal papillomas (C538682)
........expandKeratoderma, Palmoplantar, Epidermolytic (D053546) Child1
........expandPalmoplantar Keratoderma, Nonepidermolytic (C563422) Child1



 Sister Nodes: 
..expandAcrokeratoelastoidosis of Costa (C535653)
..expandAlopecia congenita keratosis palmoplantaris (C537050)
..expandBasaran Yilmaz syndrome (C537660)
..expandCardiomyopathy dilated with Woolly hair and keratoderma (C535581)
..expandCerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (C537943)
..expandCorneodermatoosseous syndrome (C536444)
..expandFitzsimmons-McLachlan-Gilbert syndrome (C537058)
..expandHyperkeratosis-Hyperpigmentation Syndrome (C564172)
..expandHypotrichosis-Osteolysis-Periodontitis-Palmoplantar Keratoderma Syndrome (C564357)
..expandJudge Misch Wright syndrome (C537692)
..expandKeratoderma palmoplantar deafness (C536152)
..expandKeratoderma palmoplantar spastic paralysis (C536153)
..expandKeratoderma, Palmoplantar, Diffuse (D015776) Child7
..expandKeratoderma, Palmoplantar, Norrbotten Recessive Type (C565454)
..expandKeratosis focal palmoplantar gingival (C536157)
..expandKeratosis Palmaris et Plantaris with Clinodactyly (C563646)
..expandKeratosis palmoplantaris papulosa (C536161)
..expandKeratosis palmoplantaris striata 1 (C536162)
..expandKeratosis palmoplantaris striata 3 (C536163)
..expandKeratosis Palmoplantaris Striata II (C565102)
..expandKeratosis palmoplantaris with esophageal cancer (C536164)
..expandKnuckle pads, leuconychia and sensorineural deafness (C537210)
..expandNaegeli syndrome (C538331)
..expandNaxos disease (C538346)
..expandPalmoplantar Hyperkeratosis And True Hermaphroditism (C567165)
..expandPALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND 46,XX SEX REVERSAL (OMIM:610644)
..expandPalmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and Sex Reversal (C565693)
..expandPalmoplantar Keratoderma with Deafness (C580359)
..expandPalmoplantar Keratoderma, Epidermolytic, with Knuckle Pads (C564171)
..expandPapillon-Lefevre Disease (D010214) Child2
..expandPatel Bixler syndrome (C536306)
..expandPorokeratosis punctata palmaris et plantaris (C536338)
..expandPowell Venencie Gordon syndrome (C538358)
..expandSchopf-Schulz-Passarge Syndrome (C565607)
..expandStern Lubinsky Durrie syndrome (C537488)
..expandVohwinkel syndrome (C536457)
   

Human Disease MESH is developed by UMLS.
Further data from MedGen, OMIM, CTD
Term ID:6064
Name:Keratoderma, Palmoplantar, Diffuse
Definition:An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.
Alternative IDs:
ParentIDs:MESH:D007645
TreeNumbers:C16.320.850.475.440 |C17.800.428.435.440 |C17.800.827.475.440
Synonyms:Keratosis Palmaris et Plantaris Familiaris |Syndrome, Thost-Unna |Syndrome, Unna-Thost |Thost Unna Syndrome |Thost-Unna Syndrome |Tylosis |Unna Thost Syndrome |Unna-Thost Syndrome
Slim Mappings:Genetic disease (inborn)|Skin disease
Reference: MedGen: D015776
MeSH: D015776
OMIM:

Genes:
Phenotypes
Disease Causing ClinVar Variants