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Disease Browser
Parent Node:
expandColorectal Neoplasms (D015179)
Parent Node:
expandDNA Repair-Deficiency Disorders (D049914)
Parent Node:
expandNeoplastic Syndromes, Hereditary (D009386)
..Starting node
..expandColorectal Neoplasms, Hereditary Nonpolyposis (D003123)

       Child Nodes:
........expandColorectal cancer, hereditary nonpolyposis, type 1 (C535972)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 3 (C563972)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 4 (C563971)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 5 (C563456)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 6 (C566039)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 7 (C565777)
........expandColorectal Cancer, Hereditary Nonpolyposis, Type 8 (C567685)
........expandLynch syndrome I (site-specific colonic cancer) (C537261)
........expandLynch Syndrome II (D055847) Child1



 Sister Nodes: 
..expandAdenomatous Polyposis Coli (D011125) Child10
..expandBasal Cell Nevus Syndrome (D001478) Child1
..expandBirt-Hogg-Dube Syndrome (D058249)
..expandCancer, Familial, with In Vitro Radioresistance (C566179)
..expandCollagenoma, Familial Cutaneous (C562925)
..expandColorectal Neoplasms, Hereditary Nonpolyposis (D003123) Child10
..expandDiaphyseal medullary stenosis with malignant fibrous histiocytoma (C536169)
..expandDysplastic Nevus Syndrome (D004416)
..expandExostoses, Multiple Hereditary (D005097) Child14
..expandFamilial cylindromatosis (C536611)
..expandGenochondromatosis (C563215)
..expandHamartoma Syndrome, Multiple (D006223) Child10
..expandHemangioma, capillary infantile (C535860)
..expandHereditary Breast and Ovarian Cancer Syndrome (D061325)
..expandJuvenile polyposis syndrome (C537702)
..expandLi-Fraumeni Syndrome (D016864) Child4
..expandMelanoma-Pancreatic Cancer Syndrome (C563985)
..expandMeningioma, familial (C537443)
..expandMultiple Endocrine Neoplasia (D009377) Child6
..expandMyelocytic leukemia-like syndrome, familial, chronic (C536093)
..expandNeurofibromatoses (D017253) Child13
..expandParagangliomas 2 (C566646)
..expandParagangliomas 3 (C565335)
..expandPeutz-Jeghers Syndrome (D010580)
..expandProstate Cancer, Hereditary, 12 (C567510)
..expandTrichoepithelioma multiple familial (C536552)
..expandTuberous Sclerosis (D014402) Child4
..expandTurcot syndrome (C536928)
..expandWilms Tumor (D009396) Child10
   

Human Disease MESH is developed by UMLS.
Further data from MedGen, OMIM, CTD
Term ID:2517
Name:Colorectal Neoplasms, Hereditary Nonpolyposis
Definition:A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Alternative IDs:
ParentIDs:MESH:D009386|MESH:D015179|MESH:D049914
TreeNumbers:C04.588.274.476.411.307.190 |C04.700.250 |C06.301.371.411.307.190 |C06.405.249.411.307.190 |C06.405.469.158.356.190 |C06.405.469.491.307.190 |C16.320.700.250 |C18.452.284.255
Synonyms:Colon Cancer, Familial Nonpolyposis |Colorectal Cancer Hereditary Nonpolyposis |Familial Nonpolyposis Colon Cancer |Hereditary Nonpolyposis Colon Cancer |Hereditary Nonpolyposis Colorectal Cancer |Hereditary Nonpolyposis Colorectal Neoplasms |Lynch Cancer Fami
Slim Mappings:Cancer|Digestive system disease|Genetic disease (inborn)|Metabolic disease
Reference: MedGen: D003123
MeSH: D003123
OMIM:

Genes:
Phenotypes
Disease Causing ClinVar Variants