Human Phenotype Ontology 
Grandparent Node:
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Abnormality of connective tissue (HP:0003549)help
Parent Node:
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Abnormal adipose tissue morphology (HP:0009124)help
Parent Node:
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Increased connective tissue (HP:0009025)help
..Starting node
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Increased adipose tissue (HP:0009126)help
Term ID: 9126
Name: Increased adipose tissue
Synonym: Increased adipose tissue; Increased fat tissue
Definition: An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).
Comments:
Reference: HP:0009126
Genes and Diseases:
 
       Child Nodes:
........expandIncreased adipose tissue around the neck (HP:0000468) help
........expandIncreased intramuscular fat (HP:0008985) help
........expandIncreased intraabdominal fat (HP:0008993) help
........expandIncreased subcutaneous truncal adipose tissue (HP:0009003) help
........expandLipedema (HP:0100695) help

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009126HP:0009126Increased adipose tissue0AKT2 CL E G H208392ORPHA:79085AKT2-related familial partial lipodystrophy12
HP:0009126HP:0009126Increased adipose tissue0CHCHD10 CL E G H40091615559ORPHA:276435Lower motor neuron syndrome with late-adult onset11
HP:0009126HP:0009126Increased adipose tissue0INPP5K CL E G H5176333882OMIM:617404Muscular dystrophy, congenital, with cataracts and intellectual disability.7
HP:0009126HP:0009126Increased adipose tissue0LIPE CL E G H39916621ORPHA:435660LIPE-related familial partial lipodystrophy7
HP:0009126HP:0009126Increased adipose tissue0LMNA CL E G H40006636ORPHA:280365Autosomal semi-dominant severe lipodystrophic laminopathy645
HP:0009126HP:0009126Increased adipose tissue0LMNA CL E G H40006636OMIM:151660Lipodystrophy, familial partial, type 2645
HP:0009126HP:0009126Increased adipose tissue0LMNA CL E G H40006636OMIM:248370Mandibuloacral dysplasia645
HP:0009126HP:0009126Increased adipose tissue0MC4R CL E G H41606932ORPHA:71529Obesity due to melanocortin 4 receptor deficiencyHP:0040280 - Obligate54
HP:0009126HP:0009126Increased adipose tissue0PCSK1 CL E G H51228743ORPHA:71528Obesity due to prohormone convertase I deficiencyHP:0040280 - Obligate65
HP:0009126HP:0009126Increased adipose tissue0POLR3A CL E G H1112830074ORPHA:3455Wiedemann-Rautenstrauch syndrome138
HP:0009126HP:0009126Increased adipose tissue0POMC CL E G H54439201ORPHA:71526Obesity due to pro-opiomelanocortin deficiencyHP:0040280 - Obligate27
HP:0009126HP:0009126Increased adipose tissue0TRNK CL E G H45667489ORPHA:1349Mitochondrial DNA-related cardiomyopathy and hearing lossHP:0040283 - Occasional
HP:0009126HP:0100695Lipedema1 CL E G H
HP:0009126HP:0008993Increased intraabdominal fat1AKT2 CL E G H208392ORPHA:79085AKT2-related familial partial lipodystrophyHP:0040281 - Very frequent12
HP:0009126HP:0008985Increased intramuscular fat1CHCHD10 CL E G H40091615559ORPHA:276435Lower motor neuron syndrome with late-adult onsetHP:0040282 - Frequent11
HP:0009126HP:0008993Increased intraabdominal fat1LIPE CL E G H39916621ORPHA:435660LIPE-related familial partial lipodystrophyHP:0040281 - Very frequent7
HP:0009126HP:0000468Increased adipose tissue around the neck1LIPE CL E G H39916621ORPHA:435660LIPE-related familial partial lipodystrophyHP:0040280 - Obligate7
HP:0009126HP:0000468Increased adipose tissue around the neck1LMNA CL E G H40006636ORPHA:280365Autosomal semi-dominant severe lipodystrophic laminopathyHP:0040282 - Frequent645
HP:0009126HP:0008993Increased intraabdominal fat1LMNA CL E G H40006636ORPHA:280365Autosomal semi-dominant severe lipodystrophic laminopathyHP:0040282 - Frequent645
HP:0009126HP:0000468Increased adipose tissue around the neck1LMNA CL E G H40006636OMIM:151660Lipodystrophy, familial partial, type 2.645
HP:0009126HP:0008993Increased intraabdominal fat1LMNA CL E G H40006636OMIM:151660Lipodystrophy, familial partial, type 2.645
HP:0009126HP:0008985Increased intramuscular fat1LMNA CL E G H40006636OMIM:151660Lipodystrophy, familial partial, type 2.645
HP:0009126HP:0000468Increased adipose tissue around the neck1LMNA CL E G H40006636OMIM:248370Mandibuloacral dysplasia645
HP:0009126HP:0009003Increased subcutaneous truncal adipose tissue1POLR3A CL E G H1112830074ORPHA:3455Wiedemann-Rautenstrauch syndromeHP:0040282 - Frequent138


Genes (10) :AKT2 CHCHD10 INPP5K LIPE LMNA MC4R PCSK1 POLR3A POMC TRNK

Diseases (12) :ORPHA:79085 ORPHA:276435 OMIM:617404 ORPHA:435660 ORPHA:280365 OMIM:151660 OMIM:248370 ORPHA:71529 ORPHA:71528 ORPHA:3455 ORPHA:71526 ORPHA:1349
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.