Human Phenotype Ontology 
Grandparent Node:
expand
Abnormal emotion/affect behavior (HP:0100851)help
Parent Node:
expand
Diminished motivation (HP:0000745)help
..Starting node
..expand
Apathy (HP:0000741)help
Term ID: 741
Name: Apathy
Synonym: Lack of feeling, emotion, interest
Definition:
Comments:
Reference: HP:0000741
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbulia (HP:0012671) help
..expandAkinetic mutism (HP:0012672) help
..expandInertia (HP:0030216) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000741HP:0000741Apathy0C9orf72 CL E G H203228275872ORPHA117328337614260
HP:0000741HP:0000741Apathy0C9orf72 CL E G H203228105550Amyotrophic lateral sclerosis and/or frontotemporal dementia 1105550C1862937OMIM117328337614260
HP:0000741HP:0000741Apathy0CACNA1A CL E G H77371518ORPHA126891388601011
HP:0000741HP:0000741Apathy0CHCHD10 CL E G H400916275872ORPHA124815559615903
HP:0000741HP:0000741Apathy0CHMP2B CL E G H25978600795Frontotemporal Dementia, Chromosome 3-Linked600795C1833296OMIM114124537609512
HP:0000741HP:0000741Apathy0COQ2 CL E G H2723598933ORPHA120525223609825
HP:0000741HP:0000741Apathy0DCTN1 CL E G H1639178509ORPHA18582711601143
HP:0000741HP:0000741Apathy0DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM18582711601143
HP:0000741HP:0000741Apathy0DNMT1 CL E G H1786614116Hereditary sensory neuropathy type IE614116C3279885OMIM19952976126375
HP:0000741HP:0000741Apathy0FUS CL E G H2521275872ORPHA14094010137070
HP:0000741HP:0000741Apathy0GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM14177606463
HP:0000741HP:0000741Apathy0GM2A CL E G H2760272750Tay-Sachs disease, variant AB272750C0268275OMIM11664367613109
HP:0000741HP:0000741Apathy0GRN CL E G H2896607485Frontotemporal dementia, ubiquitin-positive607485C1843792OMIM14174601138945
HP:0000741HP:0000741Apathy0HEXA CL E G H3073272800Tay-Sachs disease272800C0039373OMIM17704878606869
HP:0000741HP:0000741Apathy0HMGCL CL E G H3155246450Deficiency of hydroxymethylglutaryl-CoA lyase246450C0268601OMIM13275005613898
HP:0000741HP:0000741Apathy0JPH3 CL E G H57338606438Huntington disease-like 2606438C1847987OMIM112514203605268
HP:0000741HP:0000741Apathy0MAPT CL E G H4137600274Frontotemporal dementia600274C0338451OMIM15146893157140
HP:0000741HP:0000741Apathy0MAPT CL E G H4137172700Pick's disease172700C0236642OMIM15146893157140
HP:0000741HP:0000741Apathy0MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM15146893157140
HP:0000741HP:0000741Apathy0PDGFB CL E G H5155615483Idiopathic basal ganglia calcification 5615483C3809645OMIM11058800190040
HP:0000741HP:0000741Apathy0PRKAR1B CL E G H5575412066ORPHA11889390176911
HP:0000741HP:0000741Apathy0PRNP CL E G H5621282166ORPHA11649449176640
HP:0000741HP:0000741Apathy0PRNP CL E G H5621123400Jakob-Creutzfeldt disease123400C0022336OMIM11649449176640
HP:0000741HP:0000741Apathy0PSEN1 CL E G H5663600274Frontotemporal dementia600274C0338451OMIM14529508104311
HP:0000741HP:0000741Apathy0PSEN1 CL E G H5663172700Pick's disease172700C0236642OMIM14529508104311
HP:0000741HP:0000741Apathy0SMARCB1 CL E G H659899966ORPHA190111103601607
HP:0000741HP:0000741Apathy0SPAST CL E G H6683182601Spastic paraplegia 4, autosomal dominant182601C1866855OMIM1101411233604277
HP:0000741HP:0000741Apathy0SQSTM1 CL E G H8878275872ORPHA154211280601530
HP:0000741HP:0000741Apathy0SQSTM1 CL E G H8878616437Frontotemporal dementia and/or amyotrophic lateral sclerosis 3616437C4225326OMIM154211280601530
HP:0000741HP:0000741Apathy0TARDBP CL E G H23435275872ORPHA125911571605078
HP:0000741HP:0000741Apathy0TARDBP CL E G H23435612069Amyotrophic lateral sclerosis type 10612069C2677565OMIM125911571605078
HP:0000741HP:0000741Apathy0TBK1 CL E G H29110275872ORPHA129411584604834
HP:0000741HP:0000741Apathy0TBK1 CL E G H29110616439Frontotemporal dementia and/or amyotrophic lateral sclerosis 4616439C4225325OMIM129411584604834
HP:0000741HP:0000741Apathy0TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM119225186616101
HP:0000741HP:0000741Apathy0VCP CL E G H7415275872ORPHA147312666601023
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000741HP:0000741Apathy0ATP13A2 CL E G H23400306674ORPHA073830213610513
HP:0000741HP:0000741Apathy0ATXN10 CL E G H2581498761ORPHA010810549611150
HP:0000741HP:0000741Apathy0C9orf72 CL E G H203228275864ORPHA017328337614260
HP:0000741HP:0000741Apathy0CHMP2B CL E G H25978275864ORPHA014124537609512
HP:0000741HP:0000741Apathy0COQ2 CL E G H27235227510ORPHA020525223609825
HP:0000741HP:0000741Apathy0DNAJC13 CL E G H23317411602ORPHA016530343614334
HP:0000741HP:0000741Apathy0EHMT1 CL E G H7981396147ORPHA0157024650607001
HP:0000741HP:0000741Apathy0EHMT1 CL E G H79813610253Chromosome 9q deletion syndrome610253C0795833OMIM0157024650607001
HP:0000741HP:0000741Apathy0EIF4G1 CL E G H1981411602ORPHA0943296600495
HP:0000741HP:0000741Apathy0GBA CL E G H2629411602ORPHA04177606463
HP:0000741HP:0000741Apathy0GIGYF2 CL E G H26058411602ORPHA025511960612003
HP:0000741HP:0000741Apathy0GRN CL E G H2896275864ORPHA04174601138945
HP:0000741HP:0000741Apathy0LRRK2 CL E G H120892411602ORPHA0222618618609007
HP:0000741HP:0000741Apathy0MAPT CL E G H4137275864ORPHA05146893157140
HP:0000741HP:0000741Apathy0PSEN1 CL E G H5663275864ORPHA04529508104311
HP:0000741HP:0000741Apathy0SNCA CL E G H6622411602ORPHA017711138163890
HP:0000741HP:0000741Apathy0SQSTM1 CL E G H8878275864ORPHA054211280601530
HP:0000741HP:0000741Apathy0TMEM106B CL E G H54664275864ORPHA08722407613413
HP:0000741HP:0000741Apathy0TREM2 CL E G H54209275864ORPHA011017761605086
HP:0000741HP:0000741Apathy0VCP CL E G H7415275864ORPHA047312666601023
HP:0000741HP:0000741Apathy0VPS35 CL E G H55737411602ORPHA018413487601501


Genes (38) :ATP13A2 ATXN10 C9ORF72 C9orf72 CACNA1A CHCHD10 CHMP2B COQ2 DCTN1 DNAJC13 DNMT1 EHMT1 EIF4G1 FUS GBA GIGYF2 GM2A GRN HEXA HMGCL JPH3 LRRK2 MAPT PDGFB PRKAR1B PRNP PSEN1 SMARCB1 SNCA SPAST SQSTM1 TARDBP TBK1 TMEM106B TMEM240 TREM2 VCP VPS35

Diseases (34) :306674 98761 275872 275864 105550 71518 600795 98933 227510 178509 168605 411602 614116 96147 610253 608013 272750 607485 272800 246450 606438 600274 172700 601104 615483 412066 282166 123400 99966 182601 616437 612069 616439 607454
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.