Human Phenotype Ontology 
Grandparent Node:
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Cholestasis (HP:0001396)help
Grandparent Node:
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Dermatological manifestations of systemic disorders (HP:0001005)help
Parent Node:
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Jaundice (HP:0000952)help
..Starting node
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Prolonged neonatal jaundice (HP:0006579)help
Term ID: 6579
Name: Prolonged neonatal jaundice
Synonym: Jaundice, neonatal; Neonatal jaundice; Prolonged yellowing of skin in newborn
Definition: Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants.
Comments:
Reference: HP:0006579
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandIntermittent jaundice (HP:0001046) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0006579HP:0006579Prolonged neonatal jaundice0ADAMTS13 CL E G H11093274150Upshaw-Schulman syndrome274150C1268935OMIM11982651366604134
HP:0006579HP:0006579Prolonged neonatal jaundice0AMACR CL E G H23600214950Bile acid synthesis defect, congenital, 4214950C1858328OMIM114147451604489
HP:0006579HP:0006579Prolonged neonatal jaundice0ATP6AP1 CL E G H537300972Immunodeficiency 47300972C4310819OMIM15233868300197
HP:0006579HP:0006579Prolonged neonatal jaundice0ATP7A CL E G H538565ORPHA1357607869300011
HP:0006579HP:0006579Prolonged neonatal jaundice0CASK CL E G H8573300908Anemia, nonspherocytic hemolytic, due to G6PD deficiency300908C2720289OMIM11194461497300172
HP:0006579HP:0006579Prolonged neonatal jaundice0CCDC115 CL E G H84317616828CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIo616828C4225191OMIM154828178613734
HP:0006579HP:0006579Prolonged neonatal jaundice0CDAN1 CL E G H146059224120Congenital dyserythropoietic anemia, type I224120C0271933OMIM1691921713607465
HP:0006579HP:0006579Prolonged neonatal jaundice0G6PD CL E G H2539300908Anemia, nonspherocytic hemolytic, due to G6PD deficiency300908C2720289OMIM12293754057305900
HP:0006579HP:0006579Prolonged neonatal jaundice0GALK1 CL E G H2584230200Deficiency of galactokinase230200C0268155OMIM1472314118604313
HP:0006579HP:0006579Prolonged neonatal jaundice0JAG1 CL E G H182118450Alagille syndrome 1118450C1956125OMIM16206456188601920
HP:0006579HP:0006579Prolonged neonatal jaundice0MPV17 CL E G H4358256810Navajo neurohepatopathy256810C1850406OMIM1501247224137960
HP:0006579HP:0006579Prolonged neonatal jaundice0NPC1 CL E G H4864257220Niemann-Pick disease type C1257220C3179455OMIM14787167897607623
HP:0006579HP:0006579Prolonged neonatal jaundice0NPC2 CL E G H10577607625Niemann-Pick disease type C2607625C1843366OMIM1277814537601015
HP:0006579HP:0006579Prolonged neonatal jaundice0PEPD CL E G H5184170100Prolidase deficiency170100C0268532OMIM1311298840613230
HP:0006579HP:0006579Prolonged neonatal jaundice0PEX1 CL E G H5189214100Zellweger syndrome214100C0043459OMIM11404898850602136
HP:0006579HP:0006579Prolonged neonatal jaundice0PEX3 CL E G H8504617370Peroxisome biogenesis disorder 10b617370C4479254OMIM1101168858603164
HP:0006579HP:0006579Prolonged neonatal jaundice0PKLR CL E G H5313766ORPHA12821199020609712
HP:0006579HP:0006579Prolonged neonatal jaundice0POU1F1 CL E G H5449613038Pituitary hormone deficiency, combined 1613038C2751608OMIM146729210173110
HP:0006579HP:0006579Prolonged neonatal jaundice0RNU4ATAC CL E G H100151683210710Osteodysplastic primordial dwarfism, type 1210710C1859452OMIM1245634016601428
HP:0006579HP:0006579Prolonged neonatal jaundice0SMPD1 CL E G H6609257200Niemann-Pick disease, type A257200C0268242OMIM125439711120607608
HP:0006579HP:0006579Prolonged neonatal jaundice0TBX19 CL E G H9095199296ORPHA12711311596604614
HP:0006579HP:0006579Prolonged neonatal jaundice0TREX1 CL E G H11277225750Aicardi Goutieres syndrome 1225750C0796126OMIM17115312269606609
HP:0006579HP:0006579Prolonged neonatal jaundice0TRHR CL E G H720199832ORPHA174912299188545
HP:0006579HP:0006579Prolonged neonatal jaundice0UGT1A1 CL E G H5465879235ORPHA115118812530191740
HP:0006579HP:0006579Prolonged neonatal jaundice0UGT1A1 CL E G H5465879234ORPHA115118812530191740
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006579HP:0006579Prolonged neonatal jaundice0ACADL CL E G H3399900ORPHA023388609576
HP:0006579HP:0006579Prolonged neonatal jaundice0ADAR CL E G H10351ORPHA0229316225146920
HP:0006579HP:0006579Prolonged neonatal jaundice0IFIH1 CL E G H6413551ORPHA02828618873606951
HP:0006579HP:0006579Prolonged neonatal jaundice0RNASEH2A CL E G H1053551ORPHA02113318518606034
HP:0006579HP:0006579Prolonged neonatal jaundice0RNASEH2B CL E G H7962151ORPHA04214925671610326
HP:0006579HP:0006579Prolonged neonatal jaundice0RNASEH2C CL E G H8415351ORPHA01511224116610330
HP:0006579HP:0006579Prolonged neonatal jaundice0SAMHD1 CL E G H2593951ORPHA05720015925606754
HP:0006579HP:0006579Prolonged neonatal jaundice0TREX1 CL E G H1127751ORPHA07115312269606609


Genes (31) :ACADL ADAMTS13 ADAR AMACR ATP6AP1 ATP7A CASK CCDC115 CDAN1 G6PD GALK1 IFIH1 JAG1 MPV17 NPC1 NPC2 PEPD PEX1 PEX3 PKLR POU1F1 RNASEH2A RNASEH2B RNASEH2C RNU4ATAC SAMHD1 SMPD1 TBX19 TREX1 TRHR UGT1A1

Diseases (26) :99900 274150 51 214950 300972 565 300908 616828 224120 230200 118450 256810 257220 607625 170100 214100 617370 766 613038 210710 257200 199296 225750 99832 79234 79235
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.