Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal incisor morphology (HP:0011063)

Grandparent Node:
Conical tooth (HP:0000698)

Parent Node:
Conical incisor (HP:0011065)

..Starting node
..Peg-shaped maxillary lateral incisors (HP:0006342)

Term ID:

6342

Name:

Peg-shaped maxillary lateral incisors

Synonym:

Cone shaped upper lateral incisors; Conical maxillary lateral incisors; Conoid upper lateral incisors; Peg laterals; Peg shaped upper lateral incisors; Peg-shaped tooth; Pointed upper lateral incisors

Definition:

A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter

Comments:

Reference:

HP:0006342

Genes and Diseases:

Child Nodes:

Sister Nodes:

Conical mandibular incisor (HP:0006339)

Conical maxillary incisor (HP:0011083)

Conical primary incisor (HP:0011082)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	ARHGAP29 CL E G H	9411	30207	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	6
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	AXIN2 CL E G H	8313	904	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	435
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	BMP4 CL E G H	652	1071	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	38
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	CDH1 CL E G H	999	1748	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	1003
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	DLG1 CL E G H	1739	2900	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	DLX4 CL E G H	1748	2917	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	1
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	EDA CL E G H	1896	3157	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	115
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	EDARADD CL E G H	128178	14341	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	56
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	FGF3 CL E G H	2248	3681	OMIM:610706	Deafness, congenital, with inner ear agenesis, microtia, and microdontia		18
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	FGFR1 CL E G H	2260	3688	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	172
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	IRF6 CL E G H	3664	6121	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	99
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	IRF6 CL E G H	3664	6121	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	99
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	KAT6A CL E G H	7994	13013	OMIM:616268	Arboleda-Tham syndrome		34
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	LRP6 CL E G H	4040	6698	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	26
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	MSX1 CL E G H	4487	7391	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	12
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	MSX1 CL E G H	4487	7391	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	12
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	NECTIN1 CL E G H	5818	9706	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	4
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	NEK1 CL E G H	4750	7744	ORPHA:2751	Orofaciodigital syndrome type 2	HP:0040283 - Occasional	101
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	PAX9 CL E G H	5083	8623	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	58
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	PDGFRA CL E G H	5156	8803	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	337
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	SUMO1 CL E G H	7341	12502	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	8
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	TGFA CL E G H	7039	11765	ORPHA:99798	Oligodontia	HP:0040283 - Occasional
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	TP63 CL E G H	8626	15979	ORPHA:199306	Cleft lip/palate	HP:0040283 - Occasional	140
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	WNT10A CL E G H	80326	13829	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	71
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	WNT10A CL E G H	80326	13829	OMIM:150400	Tooth agenesis, selective, 4	.	71
HP:0006342	HP:0006342	Peg-shaped maxillary lateral incisors	0	WNT10B CL E G H	7480	12775	ORPHA:99798	Oligodontia	HP:0040283 - Occasional	4

Genes (23) :ARHGAP29 AXIN2 BMP4 CDH1 DLG1 DLX4 EDA EDARADD FGF3 FGFR1 IRF6 KAT6A LRP6 MSX1 NECTIN1 NEK1 PAX9 PDGFRA SUMO1 TGFA TP63 WNT10A WNT10B

Diseases (6) :ORPHA:199306 ORPHA:99798 OMIM:610706 OMIM:616268 ORPHA:2751 OMIM:150400

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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