Human Phenotype Ontology 
Grandparent Node:
expandAbnormal facial skeleton morphology (HP:0011821)help
Parent Node:
expandAbnormal shape of the frontal region (HP:0011218)help
Parent Node:
expandHypoplastic facial bones (HP:0002692)help
..Starting node
..expandHypoplasia of the frontal bone (HP:0005466)help
Term ID: 5466
Name: Hypoplasia of the frontal bone
Synonym: Decreased size of bone of forehead; Hypoplastic frontal bones; Hypotrophic frontal bone; Hypotrophic frontal bones; Small bone of forehead; Thin bone of forehead; Underdevelopment of bone of forehead
Definition: Underdevelopment of the frontal bone.
Comments:
Reference: HP:0005466
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandHypoplasia of the premaxilla (HP:0010650) help
..expandHypoplasia of the zygomatic bone (HP:0010669) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005466HP:0005466Hypoplasia of the frontal bone0ALX1 CL E G H80921494ORPHA:306542Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndromeHP:0040282 - Frequent5
HP:0005466HP:0005466Hypoplasia of the frontal bone0FGFR1 CL E G H22603688OMIM:615465Hartsfield syndrome.172
HP:0005466HP:0005466Hypoplasia of the frontal bone0MTHFR CL E G H45247436ORPHA:563612Isolated exencephalyHP:0040282 - Frequent183
HP:0005466HP:0005466Hypoplasia of the frontal bone0VANGL2 CL E G H5721615511ORPHA:563612Isolated exencephalyHP:0040282 - Frequent2


Genes (4) :ALX1 FGFR1 MTHFR VANGL2

Diseases (3) :ORPHA:306542 OMIM:615465 ORPHA:563612
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.