Human Phenotype Ontology 
Grandparent Node:
expandAbnormality of glycosaminoglycan metabolism (HP:0004371)help
Parent Node:
expandAbnormality of mucopolysaccharide metabolism (HP:0011020)help
..Starting node
..expandCellular metachromasia (HP:0003653)help
Term ID: 3653
Name: Cellular metachromasia
Synonym:
Definition: Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans.
Comments:
Reference: HP:0003653
Genes and Diseases:
 
       Child Nodes:
........expandFibroblast metachromasia (HP:0003610) help

 Sister Nodes: 
..expandMucopolysacchariduria (HP:0008155) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003653HP:0003653Cellular metachromasia0GNS CL E G H27994422OMIM:252940Mucopolysaccharidosis, type IIID.69
HP:0003653HP:0003653Cellular metachromasia0HGSNAT CL E G H13805026527OMIM:252930Mucopolysaccharidosis type IIIC.86
HP:0003653HP:0003610Fibroblast metachromasia1 CL E G H


Genes (2) :GNS HGSNAT

Diseases (2) :OMIM:252940 OMIM:252930
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.