Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal circulating protein concentration (HP:0010876)

Parent Node:
Abnormal circulating albumin concentration (HP:0012116)

..Starting node
..Hypoalbuminemia (HP:0003073)

Term ID:

3073

Name:

Hypoalbuminemia

Synonym:

Hypoalbuminaemia; Low albumin; Low blood albumin

Definition:

Reduction in the concentration of albumin in the blood.

Comments:

Reference:

HP:0003073

Genes and Diseases:

Child Nodes:

Sister Nodes:

Hyperalbuminemia (HP:0012117)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003073	HP:0003073	Hypoalbuminemia	0	ACTN4 CL E G H	81	166	OMIM:603278	Focal segmental glomerulosclerosis 1	.	27
HP:0003073	HP:0003073	Hypoalbuminemia	0	ACTN4 CL E G H	81	166	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	27
HP:0003073	HP:0003073	Hypoalbuminemia	0	AHCY CL E G H	191	343	ORPHA:88618	S-adenosylhomocysteine hydrolase deficiency	HP:0040281 - Very frequent	31
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALB CL E G H	213	399	OMIM:616000	Analbuminemia		104
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALB CL E G H	213	399	ORPHA:86816	Congenital analbuminemia	HP:0040281 - Very frequent	104
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALG1 CL E G H	56052	18294	ORPHA:79327	ALG1-CDG	HP:0040282 - Frequent	58
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALG12 CL E G H	79087	19358	ORPHA:79324	ALG12-CDG	HP:0040283 - Occasional	68
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALG6 CL E G H	29929	23157	ORPHA:79320	ALG6-CDG	HP:0040283 - Occasional	66
HP:0003073	HP:0003073	Hypoalbuminemia	0	ALG8 CL E G H	79053	23161	OMIM:608104	Congenital disorder of glycosylation, type Ih	.	46
HP:0003073	HP:0003073	Hypoalbuminemia	0	ANKFY1 CL E G H	51479	20763	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	ANLN CL E G H	54443	14082	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	6
HP:0003073	HP:0003073	Hypoalbuminemia	0	AP1B1 CL E G H	162	554	OMIM:242150	Ichthyosiform erythroderma, corneal involvement, and deafness
HP:0003073	HP:0003073	Hypoalbuminemia	0	APOL1 CL E G H	8542	618	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	3
HP:0003073	HP:0003073	Hypoalbuminemia	0	APTX CL E G H	54840	15984	OMIM:208920	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia		61
HP:0003073	HP:0003073	Hypoalbuminemia	0	ARHGAP24 CL E G H	83478	25361	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	4
HP:0003073	HP:0003073	Hypoalbuminemia	0	ARHGDIA CL E G H	396	678	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	3
HP:0003073	HP:0003073	Hypoalbuminemia	0	ARHGDIA CL E G H	396	678	OMIM:615244	Nephrotic syndrome, type 8	.	3
HP:0003073	HP:0003073	Hypoalbuminemia	0	ATP7B CL E G H	540	870	OMIM:277900	Wilson disease		315
HP:0003073	HP:0003073	Hypoalbuminemia	0	B2M CL E G H	567	914	OMIM:241600	Immunodeficiency 43	.	8
HP:0003073	HP:0003073	Hypoalbuminemia	0	BMPR1A CL E G H	657	1076	ORPHA:79076	Juvenile polyposis of infancy	HP:0040282 - Frequent	385
HP:0003073	HP:0003073	Hypoalbuminemia	0	BMPR1A CL E G H	657	1076	OMIM:174900	Juvenile polyposis syndrome	.	385
HP:0003073	HP:0003073	Hypoalbuminemia	0	CCBE1 CL E G H	147372	29426	OMIM:235510	Hennekam lymphangiectasia-lymphedema syndrome	.	147
HP:0003073	HP:0003073	Hypoalbuminemia	0	CD2AP CL E G H	23607	14258	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	105
HP:0003073	HP:0003073	Hypoalbuminemia	0	CD55 CL E G H	1604	2665	OMIM:226300	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	.	9
HP:0003073	HP:0003073	Hypoalbuminemia	0	COL4A3 CL E G H	1285	2204	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	161
HP:0003073	HP:0003073	Hypoalbuminemia	0	COL7A1 CL E G H	1294	2214	ORPHA:89842	Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form	HP:0040282 - Frequent	263
HP:0003073	HP:0003073	Hypoalbuminemia	0	COQ2 CL E G H	27235	25223	ORPHA:255249	Leigh syndrome with nephrotic syndrome	HP:0040281 - Very frequent	54
HP:0003073	HP:0003073	Hypoalbuminemia	0	COQ8B CL E G H	79934	19041	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	35
HP:0003073	HP:0003073	Hypoalbuminemia	0	COQ8B CL E G H	79934	19041	OMIM:615573	Nephrotic syndrome, type 9	.	35
HP:0003073	HP:0003073	Hypoalbuminemia	0	CRB2 CL E G H	286204	18688	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	12
HP:0003073	HP:0003073	Hypoalbuminemia	0	DAAM2 CL E G H	23500	18143	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	DGAT1 CL E G H	8694	2843	OMIM:615863	Diarrhea 7, protein-losing Enteropathy type	.	9
HP:0003073	HP:0003073	Hypoalbuminemia	0	DGUOK CL E G H	1716	2858	OMIM:251880	Mitochondrial DNA depletion syndrome 3 (hepatocerebral type)	.	57
HP:0003073	HP:0003073	Hypoalbuminemia	0	DHCR7 CL E G H	1717	2860	OMIM:270400	Smith-Lemli-Opitz syndrome		159
HP:0003073	HP:0003073	Hypoalbuminemia	0	EIF2AK3 CL E G H	9451	3255	ORPHA:1667	Wolcott-Rallison syndrome	HP:0040282 - Frequent	65
HP:0003073	HP:0003073	Hypoalbuminemia	0	EMP2 CL E G H	2013	3334	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	4
HP:0003073	HP:0003073	Hypoalbuminemia	0	ERCC4 CL E G H	2072	3436	OMIM:610965	XFE progeroid syndrome		158
HP:0003073	HP:0003073	Hypoalbuminemia	0	FARSA CL E G H	2193	3592	OMIM:619013	RAJAB INTERSTITIAL LUNG DISEASE WITH BRAIN CALCIFICATIONS 2; RILDBC2
HP:0003073	HP:0003073	Hypoalbuminemia	0	FARSB CL E G H	10056	17800	OMIM:613658	Rajab interstitial lung disease with brain calcifications
HP:0003073	HP:0003073	Hypoalbuminemia	0	FN1 CL E G H	2335	3778	ORPHA:84090	Fibronectin glomerulopathy	HP:0040281 - Very frequent	9
HP:0003073	HP:0003073	Hypoalbuminemia	0	FOXP3 CL E G H	50943	6106	ORPHA:37042	Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	HP:0040283 - Occasional	32
HP:0003073	HP:0003073	Hypoalbuminemia	0	GAPVD1 CL E G H	26130	23375	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	GPR35 CL E G H	2859	4492	ORPHA:171	Primary sclerosing cholangitis	HP:0040283 - Occasional	2
HP:0003073	HP:0003073	Hypoalbuminemia	0	IFNGR1 CL E G H	3459	5439	OMIM:209950	Immunodeficiency 27A, mycobacteriosis, AR		60
HP:0003073	HP:0003073	Hypoalbuminemia	0	IL12A CL E G H	3592	5969	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	IL12RB1 CL E G H	3594	5971	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional	46
HP:0003073	HP:0003073	Hypoalbuminemia	0	INF2 CL E G H	64423	23791	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	135
HP:0003073	HP:0003073	Hypoalbuminemia	0	IRF5 CL E G H	3663	6120	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional	4
HP:0003073	HP:0003073	Hypoalbuminemia	0	IRF8 CL E G H	3394	5358	OMIM:226990	Immunodeficiency 32B		5
HP:0003073	HP:0003073	Hypoalbuminemia	0	ITGA3 CL E G H	3675	6139	OMIM:614748	Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital	.	6
HP:0003073	HP:0003073	Hypoalbuminemia	0	KRT14 CL E G H	3861	6416	ORPHA:79396	Autosomal dominant generalized epidermolysis bullosa simplex, severe form	HP:0040283 - Occasional	110
HP:0003073	HP:0003073	Hypoalbuminemia	0	KRT5 CL E G H	3852	6442	ORPHA:79396	Autosomal dominant generalized epidermolysis bullosa simplex, severe form	HP:0040283 - Occasional	173
HP:0003073	HP:0003073	Hypoalbuminemia	0	MAGI2 CL E G H	9863	18957	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	59
HP:0003073	HP:0003073	Hypoalbuminemia	0	MAGI2 CL E G H	9863	18957	OMIM:617609	Nephrotic syndrome, type 15	.	59
HP:0003073	HP:0003073	Hypoalbuminemia	0	MICOS13 CL E G H	125988	33702	OMIM:618329	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 37; COXPD37
HP:0003073	HP:0003073	Hypoalbuminemia	0	MMEL1 CL E G H	79258	14668	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	MPI CL E G H	4351	7216	OMIM:602579	Congenital disorder of glycosylation, type Ib	.	51
HP:0003073	HP:0003073	Hypoalbuminemia	0	MPI CL E G H	4351	7216	ORPHA:79319	MPI-CDG	HP:0040281 - Very frequent	51
HP:0003073	HP:0003073	Hypoalbuminemia	0	MST1 CL E G H	4485	7380	ORPHA:171	Primary sclerosing cholangitis	HP:0040283 - Occasional	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	MTTP CL E G H	4547	7467	ORPHA:14	Abetalipoproteinemia	HP:0040282 - Frequent	81
HP:0003073	HP:0003073	Hypoalbuminemia	0	MYO1E CL E G H	4643	7599	OMIM:614131	Focal segmental glomerulosclerosis 6	.	3
HP:0003073	HP:0003073	Hypoalbuminemia	0	MYO1E CL E G H	4643	7599	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	3
HP:0003073	HP:0003073	Hypoalbuminemia	0	MYO5B CL E G H	4645	7603	OMIM:619868			192
HP:0003073	HP:0003073	Hypoalbuminemia	0	NLRC4 CL E G H	58484	16412	OMIM:616050	AUTOINFLAMMATION WITH INFANTILE ENTEROCOLITIS; AIFEC		30
HP:0003073	HP:0003073	Hypoalbuminemia	0	NPHS1 CL E G H	4868	7908	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	241
HP:0003073	HP:0003073	Hypoalbuminemia	0	NPHS1 CL E G H	4868	7908	OMIM:256300	Nephrotic syndrome, type 1	.	241
HP:0003073	HP:0003073	Hypoalbuminemia	0	NPHS2 CL E G H	7827	13394	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	69
HP:0003073	HP:0003073	Hypoalbuminemia	0	NPHS2 CL E G H	7827	13394	OMIM:600995	Nephrotic syndrome, type 2	.	69
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP107 CL E G H	57122	29914	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	5
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP107 CL E G H	57122	29914	OMIM:616730	Nephrotic syndrome, type 11		5
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP133 CL E G H	55746	18016	OMIM:618349	Galloway-Mowat syndrome 8	.	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP133 CL E G H	55746	18016	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP160 CL E G H	23279	18017	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP205 CL E G H	23165	18658	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP37 CL E G H	79023	29929	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP85 CL E G H	79902	8734	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	NUP93 CL E G H	9688	28958	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	5
HP:0003073	HP:0003073	Hypoalbuminemia	0	OSGEP CL E G H	55644	18028	OMIM:617729	Galloway-Mowat syndrome 3	.
HP:0003073	HP:0003073	Hypoalbuminemia	0	PAX2 CL E G H	5076	8616	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	39
HP:0003073	HP:0003073	Hypoalbuminemia	0	PDSS2 CL E G H	57107	23041	ORPHA:255249	Leigh syndrome with nephrotic syndrome	HP:0040281 - Very frequent	54
HP:0003073	HP:0003073	Hypoalbuminemia	0	PET100 CL E G H	100131801	40038	OMIM:619055	MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 12; MC4DN12		6
HP:0003073	HP:0003073	Hypoalbuminemia	0	PIK3R5 CL E G H	23533	30035	ORPHA:64753	Spinocerebellar ataxia with axonal neuropathy type 2	HP:0040283 - Occasional	11
HP:0003073	HP:0003073	Hypoalbuminemia	0	PLCE1 CL E G H	51196	17175	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	118
HP:0003073	HP:0003073	Hypoalbuminemia	0	PLCE1 CL E G H	51196	17175	OMIM:610725	Nephrotic syndrome, type 3	.	118
HP:0003073	HP:0003073	Hypoalbuminemia	0	PLVAP CL E G H	83483	13635	OMIM:618183	Diarrhea 10, protein-losing Enteropathy type	.
HP:0003073	HP:0003073	Hypoalbuminemia	0	PMM2 CL E G H	5373	9115	OMIM:212065	Congenital disorder of glycosylation, type Ia	.	150
HP:0003073	HP:0003073	Hypoalbuminemia	0	PMM2 CL E G H	5373	9115	ORPHA:79318	PMM2-CDG	HP:0040283 - Occasional	150
HP:0003073	HP:0003073	Hypoalbuminemia	0	POU2AF1 CL E G H	5450	9211	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	PRF1 CL E G H	5551	9360	ORPHA:540	Familial hemophagocytic lymphohistiocytosis	HP:0040281 - Very frequent	58
HP:0003073	HP:0003073	Hypoalbuminemia	0	PRF1 CL E G H	5551	9360	OMIM:603553	Hemophagocytic lymphohistiocytosis, familial, 2	.	58
HP:0003073	HP:0003073	Hypoalbuminemia	0	PTEN CL E G H	5728	9588	ORPHA:79076	Juvenile polyposis of infancy	HP:0040282 - Frequent	948
HP:0003073	HP:0003073	Hypoalbuminemia	0	PTPRO CL E G H	5800	9678	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	2
HP:0003073	HP:0003073	Hypoalbuminemia	0	PTPRO CL E G H	5800	9678	OMIM:614196	Nephrotic syndrome, type 6	.	2
HP:0003073	HP:0003073	Hypoalbuminemia	0	RNU7-1 CL E G H	100147744	34033	OMIM:619487	AICARDI-GOUTIERES SYNDROME 9; AGS9
HP:0003073	HP:0003073	Hypoalbuminemia	0	SAR1B CL E G H	51128	10535	OMIM:246700	Chylomicron retention disease	.	8
HP:0003073	HP:0003073	Hypoalbuminemia	0	SEMA4D CL E G H	10507	10732	ORPHA:171	Primary sclerosing cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	SETX CL E G H	23064	445	ORPHA:64753	Spinocerebellar ataxia with axonal neuropathy type 2	HP:0040283 - Occasional	162
HP:0003073	HP:0003073	Hypoalbuminemia	0	SGPL1 CL E G H	8879	10817	OMIM:617575	Nephrotic syndrome, type 14	.	8
HP:0003073	HP:0003073	Hypoalbuminemia	0	SH2D1A CL E G H	4068	10820	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		37
HP:0003073	HP:0003073	Hypoalbuminemia	0	SKIC3 CL E G H	9652	23639	OMIM:222470	Trichohepatoenteric syndrome 1	.
HP:0003073	HP:0003073	Hypoalbuminemia	0	SLC25A13 CL E G H	10165	10983	ORPHA:247585	Citrullinemia type II	HP:0040282 - Frequent	82
HP:0003073	HP:0003073	Hypoalbuminemia	0	SLC25A13 CL E G H	10165	10983	ORPHA:247598	Neonatal intrahepatic cholestasis due to citrin deficiency	HP:0040281 - Very frequent	82
HP:0003073	HP:0003073	Hypoalbuminemia	0	SLCO2A1 CL E G H	6578	10955	OMIM:614441	Hypertrophic osteoarthropathy, primary, autosomal recessive 2		13
HP:0003073	HP:0003073	Hypoalbuminemia	0	SMAD4 CL E G H	4089	6770	OMIM:174900	Juvenile polyposis syndrome	.	504
HP:0003073	HP:0003073	Hypoalbuminemia	0	SPIB CL E G H	6689	11242	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	STX11 CL E G H	8676	11429	ORPHA:540	Familial hemophagocytic lymphohistiocytosis	HP:0040281 - Very frequent	85
HP:0003073	HP:0003073	Hypoalbuminemia	0	STXBP2 CL E G H	6813	11445	ORPHA:540	Familial hemophagocytic lymphohistiocytosis	HP:0040281 - Very frequent	70
HP:0003073	HP:0003073	Hypoalbuminemia	0	SYK CL E G H	6850	11491	OMIM:619381	IMMUNODEFICIENCY 82 WITH SYSTEMIC INFLAMMATION; IMD82		1
HP:0003073	HP:0003073	Hypoalbuminemia	0	TBC1D8B CL E G H	54885	24715	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	TCF4 CL E G H	6925	11634	ORPHA:171	Primary sclerosing cholangitis	HP:0040283 - Occasional	241
HP:0003073	HP:0003073	Hypoalbuminemia	0	TDP1 CL E G H	55775	18884	ORPHA:94124	Spinocerebellar ataxia with axonal neuropathy type 1	HP:0040282 - Frequent	52
HP:0003073	HP:0003073	Hypoalbuminemia	0	TDP1 CL E G H	55775	18884	OMIM:607250	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1	.	52
HP:0003073	HP:0003073	Hypoalbuminemia	0	TFAM CL E G H	7019	11741	OMIM:617156	Mitochondrial DNA depletion syndrome 15 (hepatocerebral type)	.	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	TKFC CL E G H	26007	24552	OMIM:618805	TRIOKINASE AND FMN CYCLASE DEFICIENCY SYNDROME; TKFCD
HP:0003073	HP:0003073	Hypoalbuminemia	0	TNFSF15 CL E G H	9966	11931	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional
HP:0003073	HP:0003073	Hypoalbuminemia	0	TNPO3 CL E G H	23534	17103	ORPHA:186	Primary biliary cholangitis	HP:0040283 - Occasional	71
HP:0003073	HP:0003073	Hypoalbuminemia	0	TRMU CL E G H	55687	25481	OMIM:613070	Liver failure, infantile, transient		101
HP:0003073	HP:0003073	Hypoalbuminemia	0	TRPC6 CL E G H	7225	12338	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	107
HP:0003073	HP:0003073	Hypoalbuminemia	0	TTC26 CL E G H	79989	21882	OMIM:619534	BILIARY, RENAL, NEUROLOGIC, AND SKELETAL SYNDROME; BRENS
HP:0003073	HP:0003073	Hypoalbuminemia	0	UNC13D CL E G H	201294	23147	ORPHA:540	Familial hemophagocytic lymphohistiocytosis	HP:0040281 - Very frequent	116
HP:0003073	HP:0003073	Hypoalbuminemia	0	VPS33A CL E G H	65082	18179	ORPHA:505248	Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders	HP:0040282 - Frequent	1
HP:0003073	HP:0003073	Hypoalbuminemia	0	VPS33A CL E G H	65082	18179	OMIM:617303	Mucopolysaccharidosis-Plus syndrome		1
HP:0003073	HP:0003073	Hypoalbuminemia	0	WDR4 CL E G H	10785	12756	OMIM:618347	Galloway-Mowat syndrome 6	HP:0040284 - Very rare
HP:0003073	HP:0003073	Hypoalbuminemia	0	WDR73 CL E G H	84942	25928	OMIM:251300	Galloway-mowat syndrome 1	.	14
HP:0003073	HP:0003073	Hypoalbuminemia	0	WT1 CL E G H	7490	12796	ORPHA:656	Genetic steroid-resistant nephrotic syndrome	HP:0040283 - Occasional	177
HP:0003073	HP:0003073	Hypoalbuminemia	0	XIAP CL E G H	331	592	OMIM:308240	Lymphoproliferative syndrome, X-linked, 1		81

Genes (107) :ACTN4 AHCY ALB ALG1 ALG12 ALG6 ALG8 ANKFY1 ANLN AP1B1 APOL1 APTX ARHGAP24 ARHGDIA ATP7B B2M BMPR1A CCBE1 CD2AP CD55 COL4A3 COL7A1 COQ2 COQ8B CRB2 DAAM2 DGAT1 DGUOK DHCR7 EIF2AK3 EMP2 ERCC4 FARSA FARSB FN1 FOXP3 GAPVD1 GPR35 IFNGR1 IL12A IL12RB1 INF2 IRF5 IRF8 ITGA3 KRT14 KRT5 MAGI2 MICOS13 MMEL1 MPI MST1 MTTP MYO1E MYO5B NLRC4 NPHS1 NPHS2 NUP107 NUP133 NUP160 NUP205 NUP37 NUP85 NUP93 OSGEP PAX2 PDSS2 PET100 PIK3R5 PLCE1 PLVAP PMM2 POU2AF1 PRF1 PTEN PTPRO RNU7-1 SAR1B SEMA4D SETX SGPL1 SH2D1A SKIC3 SLC25A13 SLCO2A1 SMAD4 SPIB STX11 STXBP2 SYK TBC1D8B TCF4 TDP1 TFAM TKFC TNFSF15 TNPO3 TRMU TRPC6 TTC26 UNC13D VPS33A WDR4 WDR73 WT1 XIAP

Diseases (77) :OMIM:603278 ORPHA:656 ORPHA:88618 OMIM:616000 ORPHA:86816 ORPHA:79327 ORPHA:79324 ORPHA:79320 OMIM:608104 OMIM:242150 OMIM:208920 OMIM:615244 OMIM:277900 OMIM:241600 ORPHA:79076 OMIM:174900 OMIM:235510 OMIM:226300 ORPHA:89842 ORPHA:255249 OMIM:615573 OMIM:615863 OMIM:251880 OMIM:270400 ORPHA:1667 OMIM:610965 OMIM:619013 OMIM:613658 ORPHA:84090 ORPHA:37042 ORPHA:171 OMIM:209950 ORPHA:186 OMIM:226990 OMIM:614748 ORPHA:79396 OMIM:617609 OMIM:618329 OMIM:602579 ORPHA:79319 ORPHA:14 OMIM:614131 OMIM:619868 OMIM:616050 OMIM:256300 OMIM:600995 OMIM:616730 OMIM:618349 OMIM:617729 OMIM:619055 ORPHA:64753 OMIM:610725 OMIM:618183 OMIM:212065 ORPHA:79318 ORPHA:540 OMIM:603553 OMIM:614196 OMIM:619487 OMIM:246700 OMIM:617575 OMIM:308240 OMIM:222470 ORPHA:247585 ORPHA:247598 OMIM:614441 OMIM:619381 ORPHA:94124 OMIM:607250 OMIM:617156 OMIM:618805 OMIM:613070 OMIM:619534 ORPHA:505248 OMIM:617303 OMIM:618347 OMIM:251300

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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