Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal cardiac test (HP:0500015)

Grandparent Node:
Abnormality of cardiovascular system electrophysiology (HP:0030956)

Parent Node:
Abnormal EKG (HP:0003115)

..Starting node
..Abnormal QRS complex (HP:0025074)

Term ID:

25074

Name:

Abnormal QRS complex

Synonym:

Definition:

An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram.

Comments:

Reference:

HP:0025074

Genes and Diseases:

Child Nodes:

........

Prolonged QRS complex (HP:0006677)

........

Abnormal QRS voltage (HP:0025076)

................... HP:0025075 Increased QRS voltage
................... HP:0025077 Decreased QRS voltage
................... HP:0025078 Electrical alternans

Sister Nodes:

Abnormal P wave (HP:0031595)

Abnormal PR interval (HP:0031593)

Abnormal PR segment (HP:0031596)

Abnormal QT interval (HP:0031547)

Abnormal ST segment (HP:0012249)

Abnormal T-wave (HP:0005135)

Abnormal U wave (HP:0025070)

J wave (HP:0012272)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025074	HP:0025074	Abnormal QRS complex	0	GJA5 CL E G H	2702	4279	OMIM:614049	Atrial fibrillation, familial, 11	39
HP:0025074	HP:0025074	Abnormal QRS complex	0	IRX5 CL E G H	10265	14361	OMIM:611174	Hamamy syndrome	4
HP:0025074	HP:0025074	Abnormal QRS complex	0	JUP CL E G H	3728	6207	OMIM:611528	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 12; ARVD12	222
HP:0025074	HP:0025074	Abnormal QRS complex	0	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease	222
HP:0025074	HP:0025074	Abnormal QRS complex	0	PKP2 CL E G H	5318	9024	OMIM:609040	Arrhythmogenic right ventricular dysplasia, familial, 9	406
HP:0025074	HP:0025074	Abnormal QRS complex	0	PRKAG2 CL E G H	51422	9386	OMIM:600858	Cardiomyopathy, familial hypertrophic, 6	235
HP:0025074	HP:0025074	Abnormal QRS complex	0	PRKAG2 CL E G H	51422	9386	OMIM:194200	WOLFF-PARKINSON-WHITE SYNDROME	235
HP:0025074	HP:0025074	Abnormal QRS complex	0	SVIL CL E G H	6840	11480	OMIM:619040	MYOFIBRILLAR MYOPATHY 10; MFM10	1
HP:0025074	HP:0025074	Abnormal QRS complex	0	TMEM43 CL E G H	79188	28472	OMIM:604400	Arrhythmogenic right ventricular dysplasia, familial, 5	171
HP:0025074	HP:0006677	Prolonged QRS complex	1	GJA5 CL E G H	2702	4279	OMIM:614049	Atrial fibrillation, familial, 11	39
HP:0025074	HP:0006677	Prolonged QRS complex	1	IRX5 CL E G H	10265	14361	OMIM:611174	Hamamy syndrome	4
HP:0025074	HP:0006677	Prolonged QRS complex	1	JUP CL E G H	3728	6207	OMIM:611528	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 12; ARVD12	222
HP:0025074	HP:0006677	Prolonged QRS complex	1	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease	222
HP:0025074	HP:0006677	Prolonged QRS complex	1	PKP2 CL E G H	5318	9024	OMIM:609040	Arrhythmogenic right ventricular dysplasia, familial, 9	406
HP:0025074	HP:0006677	Prolonged QRS complex	1	PRKAG2 CL E G H	51422	9386	OMIM:600858	Cardiomyopathy, familial hypertrophic, 6	235
HP:0025074	HP:0006677	Prolonged QRS complex	1	PRKAG2 CL E G H	51422	9386	OMIM:194200	WOLFF-PARKINSON-WHITE SYNDROME	235
HP:0025074	HP:0025076	Abnormal QRS voltage	1	SVIL CL E G H	6840	11480	OMIM:619040	MYOFIBRILLAR MYOPATHY 10; MFM10	1
HP:0025074	HP:0006677	Prolonged QRS complex	1	TMEM43 CL E G H	79188	28472	OMIM:604400	Arrhythmogenic right ventricular dysplasia, familial, 5	171
HP:0025074	HP:0025078	Electrical alternans	2	CL E G H
HP:0025074	HP:0025077	Decreased QRS voltage	2	CL E G H
HP:0025074	HP:0025075	Increased QRS voltage	2	SVIL CL E G H	6840	11480	OMIM:619040	MYOFIBRILLAR MYOPATHY 10; MFM10	1

Genes (7) :GJA5 IRX5 JUP PKP2 PRKAG2 SVIL TMEM43

Diseases (9) :OMIM:614049 OMIM:611174 OMIM:611528 OMIM:601214 OMIM:609040 OMIM:600858 OMIM:194200 OMIM:619040 OMIM:604400

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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