Human Phenotype Ontology 
Grandparent Node:
expandDecreased body weight (HP:0004325)help
Parent Node:
expandFailure to thrive (HP:0001508)help
..Starting node
..expandSevere failure to thrive (HP:0001525)help
Term ID: 1525
Name: Severe failure to thrive
Synonym: Marked failure to thrive; Severe faltering weight; Severe postnatal failure to thrive; Severe weight faltering
Definition:
Comments:
Reference: HP:0001525
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandFailure to thrive in infancy (HP:0001531) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001525HP:0001525Severe failure to thrive0ASXL1 CL E G H17102318318ORPHA:97297Bohring-Opitz syndromeHP:0040282 - Frequent145
HP:0001525HP:0001525Severe failure to thrive0BSND CL E G H780916512ORPHA:89938Infantile Bartter syndrome with sensorineural deafnessHP:0040283 - Occasional53
HP:0001525HP:0001525Severe failure to thrive0CLCNKA CL E G H11872026ORPHA:89938Infantile Bartter syndrome with sensorineural deafnessHP:0040283 - Occasional9
HP:0001525HP:0001525Severe failure to thrive0CLCNKB CL E G H11882027ORPHA:89938Infantile Bartter syndrome with sensorineural deafnessHP:0040283 - Occasional27
HP:0001525HP:0001525Severe failure to thrive0ERCC6 CL E G H20743438OMIM:133540Cockayne syndrome, type B.199
HP:0001525HP:0001525Severe failure to thrive0FIG4 CL E G H989616873ORPHA:3472Yunis-Varon syndromeHP:0040282 - Frequent111
HP:0001525HP:0001525Severe failure to thrive0FIG4 CL E G H989616873OMIM:216340Yunis-Varon syndrome.111
HP:0001525HP:0001525Severe failure to thrive0HYMAI CL E G H570615326OMIM:601410Diabetes mellitus, transient neonatal, 1.
HP:0001525HP:0001525Severe failure to thrive0INSR CL E G H36436091OMIM:246200Donohue syndrome.229
HP:0001525HP:0001525Severe failure to thrive0LMNA CL E G H40006636ORPHA:740Hutchinson-Gilford progeria syndromeHP:0040281 - Very frequent645
HP:0001525HP:0001525Severe failure to thrive0NALCN CL E G H25923219082ORPHA:371364Hypotonia-speech impairment-severe cognitive delay syndromeHP:0040282 - Frequent48
HP:0001525HP:0001525Severe failure to thrive0PEX7 CL E G H51918860OMIM:215100Rhizomelic chondrodysplasia punctata, type 1.72
HP:0001525HP:0001525Severe failure to thrive0PRPS1 CL E G H56319462ORPHA:423479X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndromeHP:0040282 - Frequent49
HP:0001525HP:0001525Severe failure to thrive0RTTN CL E G H2591418654ORPHA:468631Microcephalic cortical malformations-short stature due to RTTN deficiencyHP:0040282 - Frequent113
HP:0001525HP:0001525Severe failure to thrive0UNC80 CL E G H28517526582ORPHA:371364Hypotonia-speech impairment-severe cognitive delay syndromeHP:0040282 - Frequent23
HP:0001525HP:0001525Severe failure to thrive0VAC14 CL E G H5569725507ORPHA:3472Yunis-Varon syndromeHP:0040282 - Frequent6
HP:0001525HP:0001525Severe failure to thrive0ZFP57 CL E G H34617118791OMIM:601410Diabetes mellitus, transient neonatal, 1.30
HP:0001525HP:0001525Severe failure to thrive0ZMPSTE24 CL E G H1026912877ORPHA:740Hutchinson-Gilford progeria syndromeHP:0040281 - Very frequent83


Genes (17) :ASXL1 BSND CLCNKA CLCNKB ERCC6 FIG4 HYMAI INSR LMNA NALCN PEX7 PRPS1 RTTN UNC80 VAC14 ZFP57 ZMPSTE24

Diseases (12) :ORPHA:97297 ORPHA:89938 OMIM:133540 ORPHA:3472 OMIM:216340 OMIM:601410 OMIM:246200 ORPHA:740 ORPHA:371364 OMIM:215100 ORPHA:423479 ORPHA:468631
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.