Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal liver morphology (HP:0410042)

Parent Node:
Hepatic necrosis (HP:0002605)

..Starting node
..Hepatocellular necrosis (HP:0001404)

Term ID:

1404

Name:

Hepatocellular necrosis

Synonym:

Death of liver cells; Hepatocellular loss

Definition:

Comments:

Reference:

HP:0001404

Genes and Diseases:

Child Nodes:

Sister Nodes:

Hepatic periportal necrosis (HP:0002614)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001404	HP:0001404	Hepatocellular necrosis	0	ACADVL CL E G H	37	92	OMIM:201475	Very long-chain acyl-CoA dehydrogenase deficiency	.	200
HP:0001404	HP:0001404	Hepatocellular necrosis	0	DGUOK CL E G H	1716	2858	OMIM:251880	Mitochondrial DNA depletion syndrome 3 (hepatocerebral type)	.	57
HP:0001404	HP:0001404	Hepatocellular necrosis	0	MPV17 CL E G H	4358	7224	OMIM:256810	Navajo neurohepatopathy		56
HP:0001404	HP:0001404	Hepatocellular necrosis	0	NHLRC2 CL E G H	374354	24731	OMIM:618278	Fibrosis, neurodegeneration, and cerebral angiomatosis	.

Genes (4) :ACADVL DGUOK MPV17 NHLRC2

Diseases (4) :OMIM:201475 OMIM:251880 OMIM:256810 OMIM:618278

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.