Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal blood glucose concentration (HP:0011015)

Parent Node:
Hypoglycemia (HP:0001943)

..Starting node
..Reactive hypoglycemia (HP:0012051)

Term ID:

12051

Name:

Reactive hypoglycemia

Synonym:

Low blood sugar after a meal; Postprandial hypoglycemia

Definition:

Hypoglycermia following a meal (or more generally, after intake of glucose).

Comments:

Reference:

HP:0012051

Genes and Diseases:

Child Nodes:

Sister Nodes:

Hypoglycemic seizures (HP:0002173)

Hypoketotic hypoglycemia (HP:0001985)

Ketotic hypoglycemia (HP:0012734)

Neonatal hypoglycemia (HP:0001998)

Nonketotic hypoglycemia (HP:0001958)

Recurrent hypoglycemia (HP:0001988)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012051	HP:0012051	Reactive hypoglycemia	0	ALDOB CL E G H	229	417	ORPHA:469	Hereditary fructose intolerance	HP:0040283 - Occasional	73
HP:0012051	HP:0012051	Reactive hypoglycemia	0	GLUD1 CL E G H	2746	4335	ORPHA:35878	Hyperinsulinism-hyperammonemia syndrome	HP:0040281 - Very frequent	56
HP:0012051	HP:0012051	Reactive hypoglycemia	0	HNF1A CL E G H	6927	11621	ORPHA:324575	Hyperinsulinism due to HNF1A deficiency	HP:0040282 - Frequent	161
HP:0012051	HP:0012051	Reactive hypoglycemia	0	MEN1 CL E G H	4221	7010	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	462
HP:0012051	HP:0012051	Reactive hypoglycemia	0	PCSK1 CL E G H	5122	8743	OMIM:600955	Proprotein convertase 1/3 deficiency	.	65
HP:0012051	HP:0012051	Reactive hypoglycemia	0	UCP2 CL E G H	7351	12518	ORPHA:276556	Hyperinsulinism due to UCP2 deficiency	HP:0040281 - Very frequent	15
HP:0012051	HP:0012051	Reactive hypoglycemia	0	YY1 CL E G H	7528	12856	ORPHA:97279	Insulinoma	HP:0040282 - Frequent	7

Genes (7) :ALDOB GLUD1 HNF1A MEN1 PCSK1 UCP2 YY1

Diseases (6) :ORPHA:469 ORPHA:35878 ORPHA:324575 ORPHA:97279 OMIM:600955 ORPHA:276556

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.