Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of temperature regulation (HP:0004370)

Parent Node:
Fever (HP:0001945)

..Starting node
..Low-grade fever (HP:0011134)

Term ID:

11134

Name:

Low-grade fever

Synonym:

Low-grade fever; Mild fever

Definition:

Mild fever that does not exceed 38.5 degrees centigrade.

Comments:

Reference:

HP:0011134

Genes and Diseases:

Child Nodes:

Sister Nodes:

Recurrent fever (HP:0001954)

Unexplained fevers (HP:0001955)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0011134	HP:0011134	Low-grade fever	0	ANKRD55 CL E G H	79722	25681	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional
HP:0011134	HP:0011134	Low-grade fever	0	CALR CL E G H	811	1455	ORPHA:824	Primary myelofibrosis	HP:0040283 - Occasional	1
HP:0011134	HP:0011134	Low-grade fever	0	CD247 CL E G H	919	1677	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional	8
HP:0011134	HP:0011134	Low-grade fever	0	IL2RA CL E G H	3559	6008	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional	65
HP:0011134	HP:0011134	Low-grade fever	0	IL2RB CL E G H	3560	6009	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional
HP:0011134	HP:0011134	Low-grade fever	0	JAK2 CL E G H	3717	6192	ORPHA:824	Primary myelofibrosis	HP:0040283 - Occasional	57
HP:0011134	HP:0011134	Low-grade fever	0	MPL CL E G H	4352	7217	ORPHA:824	Primary myelofibrosis	HP:0040283 - Occasional	97
HP:0011134	HP:0011134	Low-grade fever	0	PTPN2 CL E G H	5771	9650	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional
HP:0011134	HP:0011134	Low-grade fever	0	PTPN22 CL E G H	26191	9652	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional	3
HP:0011134	HP:0011134	Low-grade fever	0	STAT4 CL E G H	6775	11365	ORPHA:85408	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HP:0040283 - Occasional	2
HP:0011134	HP:0011134	Low-grade fever	0	TET2 CL E G H	54790	25941	ORPHA:824	Primary myelofibrosis	HP:0040283 - Occasional	3

Genes (11) :ANKRD55 CALR CD247 IL2RA IL2RB JAK2 MPL PTPN2 PTPN22 STAT4 TET2

Diseases (2) :ORPHA:85408 ORPHA:824

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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