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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Disease Browser
Parent Node: Paralysis (D010243)
..Starting node ..Paraplegia (D010264)
Child Nodes:
........Brown-Sequard Syndrome (D018437)
........Fryns Macrocephaly (C563963)
........Mental Retardation with Spastic Paraplegia (C564099)
........Optic Atrophy Spastic Paraplegia Syndrome (C564084)
........Spastic Paraplegia 24, Autosomal Recessive (C564375)
........Spastic Paraplegia 28, Autosomal Recessive (C563732)
........Spastic Paraplegia 30, Autosomal Recessive (C563677)
........Spastic Paraplegia Type 11 (C580453)
........Spastic Paraplegia Type 3a (C580455)
........Spastic Paraplegia Type 4 (C580456)
........Spastic Paraplegia Type 7 (C580457)
........Spastic Paraplegia Type 8 (C580458)
........Spastic Paraplegia, Ataxia, And Mental Retardation (C564378)
........Spastic Paraplegia, Optic Atrophy, and Neuropathy (C563702)
Sister Nodes:
..Facial Paralysis (D005158) 6
..Gastroparesis (D018589)
..Hemiplegia (D006429) 1
..Ophthalmoplegia (D009886) 41
..Paraplegia (D010264) 14
..Pseudobulbar Palsy (D020828) 1
..Quadriplegia (D011782) 4
..Respiratory Paralysis (D012133)
..Vocal Cord Paralysis (D014826) 6
..Wells Jankovic syndrome (C536692)
Human Disease MESH is developed by UMLS. Further data from MedGen, OMIM, CTD

Term ID:	8622
Name:	Paraplegia
Definition:	Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Alternative IDs:
ParentIDs:	MESH:D010243
TreeNumbers:	C10.597.622.669 \|C23.888.592.636.637
Synonyms:	Ataxic Paraplegia \|Ataxic Paraplegias \|Cerebral Paraplegia \|Cerebral Paraplegias \|Flaccid Paraplegia \|Flaccid Paraplegias \|Paralysis, Legs \|Paralysis, Lower Extremities \|Paralysis, Lower Limbs \|Paraplegia, Ataxic \|Paraplegia, Cerebral \|Paraplegia, Flaccid \|Paraplegi
Slim Mappings:	Nervous system disease\|Signs and symptoms
Reference:	MedGen: D010264 MeSH: D010264 OMIM: Genes:
Phenotypes
Disease Causing ClinVar Variants