Human Phenotype Ontology 
Grandparent Node:
expandBehavioral abnormality (HP:0000708)help
Parent Node:
expandAbnormal emotion/affect behavior (HP:0100851)help
..Starting node
..expandDiminished motivation (HP:0000745)help
Term ID: 745
Name: Diminished motivation
Synonym: Diminished motivation; Lack of initiative; Lack of motivation; Lacking in initiative; Lacks initiative
Definition: A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action.
Comments:
Reference: HP:0000745
Genes and Diseases:
 
       Child Nodes:
........expandApathy (HP:0000741) help
........expandAbulia (HP:0012671) help
........expandAkinetic mutism (HP:0012672) help
........expandInertia (HP:0030216) help

 Sister Nodes: 
..expandAbnormal aggressive, impulsive or violent behavior (HP:0006919) help
..expandConspicuously happy disposition (HP:0100024) help
..expandEmotional blunting (HP:0030213) help
..expandEuphoria (HP:0031844) help
..expandHappy demeanor (HP:0040082) help
..expandIrritability (HP:0000737) help
..expandMood swings (HP:0000720) help
..expandobsolete Mood changes (HP:0001575) help
..expandSuicidal ideation (HP:0031589) help
..expandUnhappy demeanor (HP:0031588) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000745HP:0000745Diminished motivation0 CL E G H
HP:0000745HP:0030216Inertia1 CL E G H
HP:0000745HP:0000741Apathy1 CL E G H
HP:0000745HP:0012672Akinetic mutism1 CL E G H
HP:0000745HP:0012671Abulia1 CL E G H


Genes (41) :ATP13A2 ATXN1 ATXN10 C9ORF72 CACNA1A CHCHD10 CHMP2B COQ2 DCTN1 DNAJC13 DNMT1 EHMT1 EIF4G1 FMR1 FUS GBA GIGYF2 GM2A GRN HEXA HMGCL JPH3 LRRK2 MAPT PANK2 PDGFB PRKAR1B PRNP PSEN1 SMARCB1 SNCA SPAST SPG21 SQSTM1 TARDBP TBK1 TMEM106B TMEM240 TREM2 VCP VPS35

Diseases (39) :306674 98755 98761 275864 100069 275872 105550 71518 600795 98933 227510 178509 168605 411602 614116 96147 610253 93256 608013 272750 607485 272800 246450 606438 600274 172700 601104 216873 615483 412066 282166 123400 99966 182601 248900 616437 612069 616439 607454
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.