Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Onset (HP:0003674)

Parent Node:
Adult onset (HP:0003581)

..Starting node
..Late onset (HP:0003584)

Term ID:

3584

Name:

Late onset

Synonym:

Definition:

A type of adult onset with onset of symptoms after the age of 60 years.

Comments:

Reference:

HP:0003584

Genes and Diseases:

Child Nodes:

Sister Nodes:

Middle age onset (HP:0003596)

Young adult onset (HP:0011462)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0003584	HP:0003584	Late onset	0	ABCC8 CL E G H	6833	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	1892	59	600509
HP:0003584	HP:0003584	Late onset	0	AKT2 CL E G H	208	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	146	392	164731
HP:0003584	HP:0003584	Late onset	0	APOE CL E G H	348	104310	Alzheimer disease 2	104310	C1863051	OMIM	1	166	613	107741
HP:0003584	HP:0003584	Late onset	0	BEAN1 CL E G H	146227	117210	Spinocerebellar ataxia 31	117210	C1861736	OMIM	1	56	24160	612051
HP:0003584	HP:0003584	Late onset	0	GCK CL E G H	2645	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	947	4195	138079
HP:0003584	HP:0003584	Late onset	0	HNF1B CL E G H	6928	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	697	11630	189907
HP:0003584	HP:0003584	Late onset	0	LDB3 CL E G H	11155	609452	Myofibrillar myopathy, ZASP-related	609452	C1836155	OMIM	1	1226	15710	605906
HP:0003584	HP:0003584	Late onset	0	PAX4 CL E G H	5078	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	169	8618	167413
HP:0003584	HP:0003584	Late onset	0	PPP1R3A CL E G H	5506	125853	Diabetes mellitus type 2	125853	C0011860	OMIM	1	119	9291	600917
HPO disease - gene - phenotype less frequent non-typical associations:

Genes (9) :ABCC8 AKT2 APOE BEAN1 GCK HNF1B LDB3 PAX4 PPP1R3A

Diseases (4) :125853 104310 117210 609452

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.