Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of digestive system physiology (HP:0025032)

Parent Node:
Abnormality of hepatobiliary system physiology (HP:0025155)

..Starting node
..Decreased liver function (HP:0001410)

Term ID:

1410

Name:

Decreased liver function

Synonym:

Decreased liver function; Hepatopathy; Liver dysfunction; Liver dysfunction, mild

Definition:

Reduced ability of the liver to perform its functions.

Comments:

Reference:

HP:0001410

Genes and Diseases:

Child Nodes:

........

Hepatic failure (HP:0001399)

................... HP:0006554 Acute hepatic failure
................... HP:0006583 Fatal liver failure in infancy
................... HP:0100626 Chronic hepatic failure

Sister Nodes:

Decreased mitochondrial complex III activity in liver tissue (HP:0006558)

Reye syndrome-like episodes (HP:0006582)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0001410	HP:0001410	Decreased liver function	0	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0001410	Decreased liver function	0	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0001410	Decreased liver function	0	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0001410	Decreased liver function	0	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0001410	Decreased liver function	0	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0001410	Decreased liver function	0	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0001410	Decreased liver function	0	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0001410	Decreased liver function	0	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0001410	Decreased liver function	0	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0001410	Decreased liver function	0	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0001410	Decreased liver function	0	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0001410	Decreased liver function	0	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0001410	Decreased liver function	0	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0001410	Decreased liver function	0	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0001410	Decreased liver function	0	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0001410	Decreased liver function	0	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0001410	Decreased liver function	0	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0001410	Decreased liver function	0	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0001410	Decreased liver function	0	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0001410	Decreased liver function	0	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0001410	Decreased liver function	0	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0001410	Decreased liver function	0	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0001410	Decreased liver function	0	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0001410	Decreased liver function	0	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0001410	Decreased liver function	0	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0001410	Decreased liver function	0	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0001410	Decreased liver function	0	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0001410	Decreased liver function	0	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0001410	Decreased liver function	0	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0001410	Decreased liver function	0	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0001410	Decreased liver function	0	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0001410	Decreased liver function	0	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0001410	Decreased liver function	0	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0001410	Decreased liver function	0	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0001410	Decreased liver function	0	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0001410	Decreased liver function	0	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0001410	Decreased liver function	0	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0001410	Decreased liver function	0	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0001410	Decreased liver function	0	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0001410	Decreased liver function	0	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0001410	Decreased liver function	0	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0001410	Decreased liver function	0	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0001410	Decreased liver function	0	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0001410	Decreased liver function	0	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0001410	Decreased liver function	0	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0001410	Decreased liver function	0	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0001399	Hepatic failure	1	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0001399	Hepatic failure	1	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0001399	Hepatic failure	1	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0001399	Hepatic failure	1	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0001399	Hepatic failure	1	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0001399	Hepatic failure	1	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0001399	Hepatic failure	1	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0001399	Hepatic failure	1	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0001399	Hepatic failure	1	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0001399	Hepatic failure	1	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0001399	Hepatic failure	1	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0001399	Hepatic failure	1	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0001399	Hepatic failure	1	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0001399	Hepatic failure	1	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0001399	Hepatic failure	1	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0001399	Hepatic failure	1	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0001399	Hepatic failure	1	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0001399	Hepatic failure	1	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0001399	Hepatic failure	1	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0001399	Hepatic failure	1	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0001399	Hepatic failure	1	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0001399	Hepatic failure	1	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0001399	Hepatic failure	1	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0001399	Hepatic failure	1	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0001399	Hepatic failure	1	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0001399	Hepatic failure	1	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0001399	Hepatic failure	1	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0001399	Hepatic failure	1	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0001399	Hepatic failure	1	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0001399	Hepatic failure	1	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0001399	Hepatic failure	1	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0001399	Hepatic failure	1	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0001399	Hepatic failure	1	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0001399	Hepatic failure	1	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0001399	Hepatic failure	1	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0001399	Hepatic failure	1	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0001399	Hepatic failure	1	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0001399	Hepatic failure	1	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0001399	Hepatic failure	1	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0001399	Hepatic failure	1	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0001399	Hepatic failure	1	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0001399	Hepatic failure	1	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0001399	Hepatic failure	1	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0001399	Hepatic failure	1	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0001399	Hepatic failure	1	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0001399	Hepatic failure	1	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0006554	Acute hepatic failure	2	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0100626	Chronic hepatic failure	2	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0006554	Acute hepatic failure	2	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0100626	Chronic hepatic failure	2	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0006554	Acute hepatic failure	2	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0100626	Chronic hepatic failure	2	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0006554	Acute hepatic failure	2	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0100626	Chronic hepatic failure	2	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0006554	Acute hepatic failure	2	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0100626	Chronic hepatic failure	2	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0006554	Acute hepatic failure	2	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0100626	Chronic hepatic failure	2	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0006554	Acute hepatic failure	2	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0100626	Chronic hepatic failure	2	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0006554	Acute hepatic failure	2	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0100626	Chronic hepatic failure	2	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0006554	Acute hepatic failure	2	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0100626	Chronic hepatic failure	2	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0006554	Acute hepatic failure	2	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0100626	Chronic hepatic failure	2	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0100626	Chronic hepatic failure	2	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0006554	Acute hepatic failure	2	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0006554	Acute hepatic failure	2	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0100626	Chronic hepatic failure	2	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0006554	Acute hepatic failure	2	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0100626	Chronic hepatic failure	2	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0006554	Acute hepatic failure	2	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0100626	Chronic hepatic failure	2	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0100626	Chronic hepatic failure	2	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0006554	Acute hepatic failure	2	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0100626	Chronic hepatic failure	2	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0006554	Acute hepatic failure	2	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0100626	Chronic hepatic failure	2	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0006554	Acute hepatic failure	2	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0006554	Acute hepatic failure	2	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0100626	Chronic hepatic failure	2	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0006554	Acute hepatic failure	2	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0100626	Chronic hepatic failure	2	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0006554	Acute hepatic failure	2	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0100626	Chronic hepatic failure	2	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0006554	Acute hepatic failure	2	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0100626	Chronic hepatic failure	2	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0100626	Chronic hepatic failure	2	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0006554	Acute hepatic failure	2	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0006554	Acute hepatic failure	2	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0100626	Chronic hepatic failure	2	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0006554	Acute hepatic failure	2	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0100626	Chronic hepatic failure	2	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0006554	Acute hepatic failure	2	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0100626	Chronic hepatic failure	2	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0006554	Acute hepatic failure	2	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0100626	Chronic hepatic failure	2	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0006554	Acute hepatic failure	2	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0100626	Chronic hepatic failure	2	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0006554	Acute hepatic failure	2	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0100626	Chronic hepatic failure	2	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0006554	Acute hepatic failure	2	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0100626	Chronic hepatic failure	2	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0100626	Chronic hepatic failure	2	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0006554	Acute hepatic failure	2	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0006554	Acute hepatic failure	2	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0100626	Chronic hepatic failure	2	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0100626	Chronic hepatic failure	2	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0006554	Acute hepatic failure	2	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0100626	Chronic hepatic failure	2	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0006554	Acute hepatic failure	2	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0006554	Acute hepatic failure	2	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0100626	Chronic hepatic failure	2	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0100626	Chronic hepatic failure	2	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0006554	Acute hepatic failure	2	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0006554	Acute hepatic failure	2	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0100626	Chronic hepatic failure	2	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0006554	Acute hepatic failure	2	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0100626	Chronic hepatic failure	2	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0006554	Acute hepatic failure	2	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0100626	Chronic hepatic failure	2	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0006554	Acute hepatic failure	2	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0100626	Chronic hepatic failure	2	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0006554	Acute hepatic failure	2	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0100626	Chronic hepatic failure	2	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0004448	Fulminant hepatic failure	3	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0004448	Fulminant hepatic failure	3	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0004448	Fulminant hepatic failure	3	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0004448	Fulminant hepatic failure	3	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0004448	Fulminant hepatic failure	3	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0004448	Fulminant hepatic failure	3	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0004448	Fulminant hepatic failure	3	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0004448	Fulminant hepatic failure	3	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0004448	Fulminant hepatic failure	3	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0004448	Fulminant hepatic failure	3	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0004448	Fulminant hepatic failure	3	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0004448	Fulminant hepatic failure	3	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0004448	Fulminant hepatic failure	3	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0004448	Fulminant hepatic failure	3	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0004448	Fulminant hepatic failure	3	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0004448	Fulminant hepatic failure	3	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0004448	Fulminant hepatic failure	3	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0004448	Fulminant hepatic failure	3	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0004448	Fulminant hepatic failure	3	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0004448	Fulminant hepatic failure	3	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0004448	Fulminant hepatic failure	3	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0004448	Fulminant hepatic failure	3	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0004448	Fulminant hepatic failure	3	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0004448	Fulminant hepatic failure	3	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0004448	Fulminant hepatic failure	3	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0004448	Fulminant hepatic failure	3	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0004448	Fulminant hepatic failure	3	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0004448	Fulminant hepatic failure	3	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0004448	Fulminant hepatic failure	3	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0004448	Fulminant hepatic failure	3	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0004448	Fulminant hepatic failure	3	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0004448	Fulminant hepatic failure	3	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HP:0001410	HP:0004787	Fulminant hepatitis	4	ADK CL E G H	132	614300	Hypermethioninemia due to adenosine kinase deficiency	614300	C3280381	OMIM	1	137	257	102750
HP:0001410	HP:0004787	Fulminant hepatitis	4	ALG8 CL E G H	79053	608104	Congenital disorder of glycosylation type 1H	608104	C2931002	OMIM	1	286	23161	608103
HP:0001410	HP:0004787	Fulminant hepatitis	4	APOPT1 CL E G H	84334	436271				ORPHA	1	197	20492	616003
HP:0001410	HP:0004787	Fulminant hepatitis	4	APOPT1 CL E G H	84334	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	197	20492	616003
HP:0001410	HP:0004787	Fulminant hepatitis	4	BCS1L CL E G H	617	124000	Mitochondrial complex III deficiency	124000	C1852372	OMIM	1	413	1020	603647
HP:0001410	HP:0004787	Fulminant hepatitis	4	BLVRA CL E G H	644	614156	Hyperbiliverdinemia	614156	C3279964	OMIM	1	57	1062	109750
HP:0001410	HP:0004787	Fulminant hepatitis	4	CCDC47 CL E G H	57003	618268	618268	618268		OMIM	1	45	24856	0
HP:0001410	HP:0004787	Fulminant hepatitis	4	COA7 CL E G H	65260	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	58	25716	615623
HP:0001410	HP:0004787	Fulminant hepatitis	4	COG2 CL E G H	22796	435934				ORPHA	1	228	6546	606974
HP:0001410	HP:0004787	Fulminant hepatitis	4	COG7 CL E G H	91949	608779	COG7 congenital disorder of glycosylation	608779	C2931010	OMIM	1	456	18622	606978
HP:0001410	HP:0004787	Fulminant hepatitis	4	COX10 CL E G H	1352	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	356	2260	602125
HP:0001410	HP:0004787	Fulminant hepatitis	4	COX14 CL E G H	84987	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	38	28216	614478
HP:0001410	HP:0004787	Fulminant hepatitis	4	COX20 CL E G H	116228	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	206	26970	614698
HP:0001410	HP:0004787	Fulminant hepatitis	4	COX6B1 CL E G H	1340	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	68	2280	124089
HP:0001410	HP:0004787	Fulminant hepatitis	4	COX8A CL E G H	1351	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	32	2294	123870
HP:0001410	HP:0004787	Fulminant hepatitis	4	DDOST CL E G H	1650	614507	Congenital disorder of glycosylation type Ir	614507	C3281084	OMIM	1	253	2728	602202
HP:0001410	HP:0004787	Fulminant hepatitis	4	FADD CL E G H	8772	306550				ORPHA	1	110	3573	602457
HP:0001410	HP:0004787	Fulminant hepatitis	4	FADD CL E G H	8772	613759	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	613759	C3151062	OMIM	1	110	3573	602457
HP:0001410	HP:0004787	Fulminant hepatitis	4	FASTKD2 CL E G H	22868	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	401	29160	612322
HP:0001410	HP:0004787	Fulminant hepatitis	4	GALT CL E G H	2592	230400	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	230400	C0268151	OMIM	1	719	4135	606999
HP:0001410	HP:0004787	Fulminant hepatitis	4	LARS2 CL E G H	23395	617021	Hydrops, lactic acidosis, and sideroblastic anemia	617021	C4310761	OMIM	1	416	17095	604544
HP:0001410	HP:0004787	Fulminant hepatitis	4	LIPT1 CL E G H	51601	616299	Lipoyltransferase 1 deficiency	616299	C4225379	OMIM	1	124	29569	610284
HP:0001410	HP:0004787	Fulminant hepatitis	4	MARS CL E G H	4141	615486	Interstitial lung and liver disease	615486	C4225400	OMIM	1		6898	156560
HP:0001410	HP:0004787	Fulminant hepatitis	4	MT-TN CL E G H	4570	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7493	590010
HP:0001410	HP:0004787	Fulminant hepatitis	4	MT-TS1 CL E G H	4574	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1		7497	590080
HP:0001410	HP:0004787	Fulminant hepatitis	4	MTM1 CL E G H	4534	310400	Severe X-linked myotubular myopathy	310400	C0410203	OMIM	1	807	7448	300415
HP:0001410	HP:0004787	Fulminant hepatitis	4	OCLN CL E G H	100506658	251290	Band-like calcification with simplified gyration and polymicrogyria	251290	C3489725	OMIM	1	138	8104	602876
HP:0001410	HP:0004787	Fulminant hepatitis	4	PET100 CL E G H	100131801	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	76	40038	614770
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX10 CL E G H	5192	614870	Peroxisome biogenesis disorder 6A	614870	C3553947	OMIM	1	803	8851	602859
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX10 CL E G H	5192	614871	Peroxisome biogenesis disorder 6B	614871	C3553948	OMIM	1	803	8851	602859
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX13 CL E G H	5194	614883	Peroxisome biogenesis disorder 11A	614883	C3554000	OMIM	1	497	8855	601789
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX16 CL E G H	9409	614877	Peroxisome biogenesis disorder 8B	614877	C3553960	OMIM	1	470	8857	603360
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX2 CL E G H	5828	614867	Peroxisome biogenesis disorder 5B	614867	C3542026	OMIM	1	463	9717	170993
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX26 CL E G H	55670	614873	Peroxisome biogenesis disorder 7B	614873	C3553951	OMIM	1	522	22965	608666
HP:0001410	HP:0004787	Fulminant hepatitis	4	PEX6 CL E G H	5190	614863	Peroxisome biogenesis disorder 4B	614863	C3553937	OMIM	1	1458	8859	601498
HP:0001410	HP:0004787	Fulminant hepatitis	4	RMND1 CL E G H	55005	614922	Combined oxidative phosphorylation deficiency 11	614922	C3554067	OMIM	1	262	21176	614917
HP:0001410	HP:0004787	Fulminant hepatitis	4	SCO1 CL E G H	6341	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	212	10603	603644
HP:0001410	HP:0004787	Fulminant hepatitis	4	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	405	10985	603861
HP:0001410	HP:0004787	Fulminant hepatitis	4	SLC30A10 CL E G H	55532	613280	Hypermanganesemia with dystonia 1	613280		OMIM	1	275	25355	611146
HP:0001410	HP:0004787	Fulminant hepatitis	4	STT3B CL E G H	201595	615597	Congenital disorder of glycosylation type 1x	615597	C2931007	OMIM	1	158	30611	608605
HP:0001410	HP:0004787	Fulminant hepatitis	4	TACO1 CL E G H	51204	220110	Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency	220110	C0268237	OMIM	1	117	24316	612958
HP:0001410	HP:0004787	Fulminant hepatitis	4	TALDO1 CL E G H	6888	606003	Deficiency of transaldolase	606003	C1291329	OMIM	1	210	11559	602063
HP:0001410	HP:0004787	Fulminant hepatitis	4	TMEM199 CL E G H	147007	616829	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIp	616829	C4225190	OMIM	1	82	18085	616815
HP:0001410	HP:0004787	Fulminant hepatitis	4	TRMT10C CL E G H	54931	616974	Combined oxidative phosphorylation deficiency 30	616974	C4310773	OMIM	1	54	26022	615423
HP:0001410	HP:0004787	Fulminant hepatitis	4	UQCRC2 CL E G H	7385	615160	Mitochondrial complex III deficiency, nuclear type 5	615160	C3554608	OMIM	1	235	12586	191329
HP:0001410	HP:0004787	Fulminant hepatitis	4	USP18 CL E G H	11274	617397	Pseudo-torch syndrome 2	617397	C4479376	OMIM	1	165	12616	607057
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001410	HP:0001410	Decreased liver function	0	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0001410	Decreased liver function	0	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0001410	Decreased liver function	0	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0001410	Decreased liver function	0	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0001410	Decreased liver function	0	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0001399	Hepatic failure	1	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0001399	Hepatic failure	1	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0001399	Hepatic failure	1	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0001399	Hepatic failure	1	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0001399	Hepatic failure	1	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0006554	Acute hepatic failure	2	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0100626	Chronic hepatic failure	2	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0006554	Acute hepatic failure	2	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0100626	Chronic hepatic failure	2	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0100626	Chronic hepatic failure	2	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0006554	Acute hepatic failure	2	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0100626	Chronic hepatic failure	2	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0006554	Acute hepatic failure	2	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0006583	Fatal liver failure in infancy	2	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0006554	Acute hepatic failure	2	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0100626	Chronic hepatic failure	2	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0004448	Fulminant hepatic failure	3	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0004448	Fulminant hepatic failure	3	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0004448	Fulminant hepatic failure	3	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0004448	Fulminant hepatic failure	3	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0004448	Fulminant hepatic failure	3	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0
HP:0001410	HP:0004787	Fulminant hepatitis	4	DLD CL E G H	1738	246900	Maple syrup urine disease, type 3	246900	CN043137	OMIM	0	520	2898	238331
HP:0001410	HP:0004787	Fulminant hepatitis	4	FECH CL E G H	2235	79278				ORPHA	0	356	3647	612386
HP:0001410	HP:0004787	Fulminant hepatitis	4	GANAB CL E G H	23193	600666	Polycystic kidney disease 3	600666	C1418603	OMIM	0	277	4138	104160
HP:0001410	HP:0004787	Fulminant hepatitis	4	IARS CL E G H	3376	617093	Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy	617093	C4310720	OMIM	0		5330	600709
HP:0001410	HP:0004787	Fulminant hepatitis	4	RNU12 CL E G H	267010	512260				ORPHA	0	17	19380	0

Genes (170) :ABCD3 ACAD9 ACVRL1 ADK AGPAT2 AKR1D1 ALG1 ALG6 ALG8 ALG9 ALMS1 AMACR APOPT1 ATP7B ATRX BCS1L BLVRA BSCL2 BTNL2 CACNA1S CAV1 CAVIN1 CC2D2A CCDC115 CCDC47 CEP164 COA7 COA8 COG2 COG4 COG7 COQ2 COX10 COX14 COX20 COX6B1 COX8A CPT1A CPT2 CTC1 CYC1 CYP7B1 DAXX DDOST DGUOK DKC1 DLD EIF2AK3 ENG EPM2A F5 FADD FAH FASTKD2 FECH FH FOS GALT GANAB GBA GBE1 GDF2 GFM1 GPR35 HADH HADHA HADHB HLA-B HLA-DRB1 HSD3B7 IARS IFT122 IFT172 IKZF1 IL12A IL12RB1 IL21R INPP5E IRF5 JAG1 JAK2 LARS LARS2 LIPA LIPT1 MARS MEFV MMEL1 MOGS MPI MPV17 MRPS7 MST1 MT-TN MT-TS1 MTM1 NBAS NDUFS4 NHLRC1 NHP2 NOP10 NPC1 NR1H4 OCLN OSTM1 OTC PARN PCK1 PCK2 PET100 PEX1 PEX10 PEX11B PEX12 PEX13 PEX14 PEX16 PEX19 PEX2 PEX26 PEX3 PEX5 PEX6 POLG PORCN POU2AF1 PPARG PTPN22 RMND1 RNU12 RPGRIP1L RTEL1 RYR1 SC5D SCO1 SCYL1 SERPINA1 SH2D1A SLC25A15 SLC25A20 SLC30A10 SMAD4 SP110 SPIB STT3B TACO1 TALDO1 TCF4 TERC TERT TFAM TINF2 TJP2 TMEM199 TMEM67 TNFSF15 TNPO3 TRMT10C TRMU TRNN TRNS1 TRNT TTC37 UBR1 UQCRC2 USB1 USP18 VPS13A WRAP53 XIAP

Diseases (130) :614300 608104 124000 614156 618268 220110 436271 435934 608779 614507 246900 306550 613759 79278 230400 600666 617093 617021 616299 615486 310400 251290 614870 614871 614883 614877 614867 614873 614863 614922 512260 238970 613280 615597 606003 616829 616974 615160 617397 616278 611126 774 528 235555 79327 79320 79325 79328 214950 277900 100075 797 616828 614845 613489 607426 156 228308 228305 1775 79302 613812 251880 2394 254780 177000 606812 79239 608013 232500 607765 218330 615630 186 615207 118450 75233 75234 79330 79319 602579 617872 252010 617049 259720 664 261680 261650 912 614886 203700 397 46059 616719 60 159 617156 615878 222470 243800 99901 79303 64 905 423 1454 263501 615453 1667 131 882 276700 171 71212 746 36426 615438 342 256810 616483 257220 2092 466794 79124 613070 254857 2388 609060 231530 308240

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.

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