Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
EEG abnormality (HP:0002353)

Parent Node:
Interictal EEG abnormality (HP:0025373)

..Starting node
..Increased theta frequency activity in EEG (HP:0031535)

Term ID:

31535

Name:

Increased theta frequency activity in EEG

Synonym:

Definition:

Increased frequency of theta wave activity in the electroencephalogram. Theta waves have a frequency of 3.5-7.5 Hertz, and are present in very small amounts in healthy waking adult EEGs. Theta activity is normal in small very amounts in the healthy waking adult EEG in a symmetrical distribution.

Comments:

Reference:

HP:0031535

Genes and Diseases:

Child Nodes:

Sister Nodes:

Absent posterior alpha rhythm (HP:0031518)

Continuous spike and waves during slow sleep (HP:0031491)

Normal interictal EEG (HP:0002372)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	CABP4 CL E G H	57010	1386	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	94
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	CHRNA2 CL E G H	1135	1956	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	188
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	CHRNA4 CL E G H	1137	1958	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	225
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	CHRNB2 CL E G H	1141	1962	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	88
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	CRH CL E G H	1392	2355	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	1
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	DEPDC5 CL E G H	9681	18423	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	172
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	KCNQ2 CL E G H	3785	6296	ORPHA:1949	Benign familial neonatal epilepsy	HP:0040284 - Very rare	528
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	KCNQ3 CL E G H	3786	6297	ORPHA:1949	Benign familial neonatal epilepsy	HP:0040284 - Very rare	302
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	KCNT1 CL E G H	57582	18865	ORPHA:98784	Autosomal dominant nocturnal frontal lobe epilepsy	HP:0040283 - Occasional	321
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	RPL10 CL E G H	6134	10298	ORPHA:459070	X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome	HP:0040283 - Occasional	10
HP:0031535	HP:0031535	Increased theta frequency activity in EEG	0	SETD1B CL E G H	23067	29187	OMIM:619000	INTELLECTUAL DEVELOPMENTAL DISORDER WITH SEIZURES AND LANGUAGE DELAY; IDDSELD

Genes (11) :CABP4 CHRNA2 CHRNA4 CHRNB2 CRH DEPDC5 KCNQ2 KCNQ3 KCNT1 RPL10 SETD1B

Diseases (4) :ORPHA:98784 ORPHA:1949 ORPHA:459070 OMIM:619000

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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