Human Phenotype Ontology 
Grandparent Node:
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Localized skin lesion (HP:0011355)help
Parent Node:
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Skin ulcer (HP:0200042)help
..Starting node
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Pyoderma gangrenosum (HP:0025452)help
Term ID: 25452
Name: Pyoderma gangrenosum
Synonym:
Definition: A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer.
Comments:
Reference: HP:0025452
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAcral ulceration (HP:0006121) help
..expandobsolete Acral ulceration and osteomyelitis leading to autoamputation of digits (HP:0001226) help
..expandobsolete Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet) (HP:0001862) help
..expandPenetrating foot ulcers (HP:0001026) help
..expandPressure ulcer (HP:0012399) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025452HP:0025452Pyoderma gangrenosum0CLPB CL E G H8157030664ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040283 - Occasional38
HP:0025452HP:0025452Pyoderma gangrenosum0ELANE CL E G H19913309ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040283 - Occasional79
HP:0025452HP:0025452Pyoderma gangrenosum0GFI1 CL E G H26724237ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040283 - Occasional56
HP:0025452HP:0025452Pyoderma gangrenosum0MEFV CL E G H42106998OMIM:608068NEUTROPHILIC DERMATOSIS, ACUTE FEBRILE281
HP:0025452HP:0025452Pyoderma gangrenosum0MEFV CL E G H42106998ORPHA:3243Sweet syndromeHP:0040283 - Occasional281
HP:0025452HP:0025452Pyoderma gangrenosum0NFKB1 CL E G H47907794OMIM:616576IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID127
HP:0025452HP:0025452Pyoderma gangrenosum0OTULIN CL E G H9026825118OMIM:6199863
HP:0025452HP:0025452Pyoderma gangrenosum0PSTPIP1 CL E G H90519580OMIM:604416Pyogenic sterile arthritis, pyoderma gangrenosum, and acne96
HP:0025452HP:0025452Pyoderma gangrenosum0SRP54 CL E G H672911301ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040283 - Occasional
HP:0025452HP:0025452Pyoderma gangrenosum0TCIRG1 CL E G H1031211647ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040283 - Occasional82
HP:0025452HP:0025452Pyoderma gangrenosum0WDR1 CL E G H994812754OMIM:150550Periodic fever, immunodeficiency, and thrombocytopenia syndrome


Genes (10) :CLPB ELANE GFI1 MEFV NFKB1 OTULIN PSTPIP1 SRP54 TCIRG1 WDR1

Diseases (7) :ORPHA:486 OMIM:608068 ORPHA:3243 OMIM:616576 OMIM:619986 OMIM:604416 OMIM:150550
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.