Human Phenotype Ontology 
Grandparent Node:
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Constitutional symptom (HP:0025142)help
Parent Node:
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Fatigue (HP:0012378)help
..Starting node
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Chronic fatigue (HP:0012432)help
Term ID: 12432
Name: Chronic fatigue
Synonym: Chronic extreme exhaustion; Chronic fatigue
Definition: Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.
Comments:
Reference: HP:0012432
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandEpisodic fatigue (HP:0012431) help
..expandPostexertional symptom exacerbation (HP:0030973) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012432HP:0012432Chronic fatigue0ALDH4A1 CL E G H8659406ORPHA:79101Hyperprolinemia type 2HP:0040282 - Frequent74
HP:0012432HP:0012432Chronic fatigue0BRCA1 CL E G H6721100ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent5769
HP:0012432HP:0012432Chronic fatigue0BRCA2 CL E G H6751101ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent7642
HP:0012432HP:0012432Chronic fatigue0CDKN2A CL E G H10291787ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent289
HP:0012432HP:0012432Chronic fatigue0EIF2AK4 CL E G H44027519687OMIM:234810PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE; PVOD240
HP:0012432HP:0012432Chronic fatigue0IVNS1ABP CL E G H1062516951OMIM:618969IMMUNODEFICIENCY 70; IMD70
HP:0012432HP:0012432Chronic fatigue0KRAS CL E G H38456407ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent196
HP:0012432HP:0012432Chronic fatigue0MC2R CL E G H41586930ORPHA:361Familial glucocorticoid deficiencyHP:0040282 - Frequent94
HP:0012432HP:0012432Chronic fatigue0MDM4 CL E G H41946974OMIM:618849BONE MARROW FAILURE SYNDROME 6; BMFS61
HP:0012432HP:0012432Chronic fatigue0MRAP CL E G H562461304ORPHA:361Familial glucocorticoid deficiencyHP:0040282 - Frequent26
HP:0012432HP:0012432Chronic fatigue0NLRP3 CL E G H11454816400OMIM:191900Muckle-Wells syndrome217
HP:0012432HP:0012432Chronic fatigue0NNT CL E G H235307863ORPHA:361Familial glucocorticoid deficiencyHP:0040282 - Frequent13
HP:0012432HP:0012432Chronic fatigue0PALB2 CL E G H7972826144ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent1349
HP:0012432HP:0012432Chronic fatigue0PALLD CL E G H2302217068ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent192
HP:0012432HP:0012432Chronic fatigue0PSAP CL E G H56609498OMIM:610539Gaucher disease, atypical81
HP:0012432HP:0012432Chronic fatigue0RABL3 CL E G H28528218072ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent
HP:0012432HP:0012432Chronic fatigue0SMAD2 CL E G H40876768OMIM:619656LOEYS-DIETZ SYNDROME 6; LDS67
HP:0012432HP:0012432Chronic fatigue0SMAD3 CL E G H40886769ORPHA:284984Aneurysm-osteoarthritis syndromeHP:0040282 - Frequent260
HP:0012432HP:0012432Chronic fatigue0SMAD3 CL E G H40886769OMIM:613795LOEYS-DIETZ SYNDROME 3; LDS3260
HP:0012432HP:0012432Chronic fatigue0SMAD4 CL E G H40896770ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent504
HP:0012432HP:0012432Chronic fatigue0STAR CL E G H677011359ORPHA:361Familial glucocorticoid deficiencyHP:0040282 - Frequent45
HP:0012432HP:0012432Chronic fatigue0TK2 CL E G H708411831ORPHA:254875Mitochondrial DNA depletion syndrome, myopathic formHP:0040282 - Frequent103
HP:0012432HP:0012432Chronic fatigue0TP53 CL E G H715711998ORPHA:1333Familial pancreatic carcinomaHP:0040281 - Very frequent911
HP:0012432HP:0012432Chronic fatigue0TXNRD2 CL E G H1058718155ORPHA:361Familial glucocorticoid deficiencyHP:0040282 - Frequent85


Genes (23) :ALDH4A1 BRCA1 BRCA2 CDKN2A EIF2AK4 IVNS1ABP KRAS MC2R MDM4 MRAP NLRP3 NNT PALB2 PALLD PSAP RABL3 SMAD2 SMAD3 SMAD4 STAR TK2 TP53 TXNRD2

Diseases (12) :ORPHA:79101 ORPHA:1333 OMIM:234810 OMIM:618969 ORPHA:361 OMIM:618849 OMIM:191900 OMIM:610539 OMIM:619656 ORPHA:284984 OMIM:613795 ORPHA:254875
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.