Human Phenotype Ontology 
Grandparent Node:
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Abnormal pleura morphology (HP:0002103)help
Grandparent Node:
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Edema (HP:0000969)help
Parent Node:
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Pleural effusion (HP:0002202)help
..Starting node
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Chylothorax (HP:0010310)help
Term ID: 10310
Name: Chylothorax
Synonym:
Definition: Accumulation of excessive amounts of lymphatic fluid (chyle) in the pleural cavity.
Comments:
Reference: HP:0010310
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandExudative pleural effusion (HP:0011921) help
..expandPleural empyema (HP:0011919) help
..expandTransudative pleural effusion (HP:0011920) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0010310HP:0010310Chylothorax0ADAMTS3 CL E G H9508219ORPHA:2136Hennekam syndromeHP:0040283 - Occasional1
HP:0010310HP:0010310Chylothorax0ALG14 CL E G H19985728287OMIM:619036MYOPATHY, EPILEPSY, AND PROGRESSIVE CEREBRAL ATROPHY; MEPCA12
HP:0010310HP:0010310Chylothorax0BRAF CL E G H6731097OMIM:163950Noonan syndrome 1276
HP:0010310HP:0010310Chylothorax0BTNL2 CL E G H562441142ORPHA:797SarcoidosisHP:0040283 - Occasional1
HP:0010310HP:0010310Chylothorax0CBL CL E G H8671541OMIM:613563Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemiaHP:0040283 - Occasional317
HP:0010310HP:0010310Chylothorax0CCBE1 CL E G H14737229426ORPHA:2136Hennekam syndromeHP:0040283 - Occasional147
HP:0010310HP:0010310Chylothorax0EPHB4 CL E G H20503395ORPHA:137667Capillary malformation-arteriovenous malformationHP:0040284 - Very rare3
HP:0010310HP:0010310Chylothorax0FAT4 CL E G H7963323109ORPHA:2136Hennekam syndromeHP:0040283 - Occasional114
HP:0010310HP:0010310Chylothorax0FOXC2 CL E G H23033801OMIM:153400Lymphedema-Distichiasis syndrome20
HP:0010310HP:0010310Chylothorax0HLA-DRB1 CL E G H31234948ORPHA:797SarcoidosisHP:0040283 - Occasional2
HP:0010310HP:0010310Chylothorax0KIF11 CL E G H38326388ORPHA:2526Microcephaly-lymphedema-chorioretinopathy syndromeHP:0040283 - Occasional46
HP:0010310HP:0010310Chylothorax0MAP2K1 CL E G H56046840OMIM:163950Noonan syndrome 1134
HP:0010310HP:0010310Chylothorax0PIEZO1 CL E G H978028993OMIM:616843Lymphedema, hereditary, III36
HP:0010310HP:0010310Chylothorax0PTPN11 CL E G H57819644OMIM:163950Noonan syndrome 1291
HP:0010310HP:0010310Chylothorax0RASA1 CL E G H59219871ORPHA:137667Capillary malformation-arteriovenous malformationHP:0040284 - Very rare88
HP:0010310HP:0010310Chylothorax0TSC1 CL E G H724812362ORPHA:538LymphangioleiomyomatosisHP:0040282 - Frequent1090
HP:0010310HP:0010310Chylothorax0TSC2 CL E G H724912363ORPHA:538LymphangioleiomyomatosisHP:0040282 - Frequent2738


Genes (17) :ADAMTS3 ALG14 BRAF BTNL2 CBL CCBE1 EPHB4 FAT4 FOXC2 HLA-DRB1 KIF11 MAP2K1 PIEZO1 PTPN11 RASA1 TSC1 TSC2

Diseases (10) :ORPHA:2136 OMIM:619036 OMIM:163950 ORPHA:797 OMIM:613563 ORPHA:137667 OMIM:153400 ORPHA:2526 OMIM:616843 ORPHA:538
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.