Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of coordination (HP:0011443)

Parent Node:
Poor motor coordination (HP:0002275)

..Starting node
..Poor fine motor coordination (HP:0007010)

Term ID:

7010

Name:

Poor fine motor coordination

Synonym:

Fine motor disability; Fine motor impairment; Fine motor skill dysfunction; Impaired fine motor skills

Definition:

An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.

Comments:

Reference:

HP:0007010

Genes and Diseases:

Child Nodes:

Sister Nodes:

Poor gross motor coordination (HP:0007015)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0007010	HP:0007010	Poor fine motor coordination	0	ADGRV1 CL E G H	84059	17416	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	530
HP:0007010	HP:0007010	Poor fine motor coordination	0	ALMS1 CL E G H	7840	428	ORPHA:64	Alström syndrome	HP:0040283 - Occasional	404
HP:0007010	HP:0007010	Poor fine motor coordination	0	C19ORF12 CL E G H	83636	25443	ORPHA:320370	Autosomal recessive spastic paraplegia type 43	HP:0040281 - Very frequent	114
HP:0007010	HP:0007010	Poor fine motor coordination	0	CXCR4 CL E G H	7852	2561	ORPHA:51636	WHIM syndrome	HP:0040283 - Occasional	9
HP:0007010	HP:0007010	Poor fine motor coordination	0	DARS2 CL E G H	55157	25538	ORPHA:137898	Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome	HP:0040283 - Occasional	60
HP:0007010	HP:0007010	Poor fine motor coordination	0	DCC CL E G H	1630	2701	ORPHA:238722	Familial congenital mirror movements	HP:0040282 - Frequent	36
HP:0007010	HP:0007010	Poor fine motor coordination	0	DLK1 CL E G H	8788	2907	ORPHA:96184	Temple syndrome due to maternal uniparental disomy of chromosome 14	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	DLK1 CL E G H	8788	2907	ORPHA:254531	Temple syndrome due to paternal 14q32.2 hypomethylation	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	DLK1 CL E G H	8788	2907	ORPHA:254525	Temple syndrome due to paternal 14q32.2 microdeletion	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	DMPK CL E G H	1760	2933	ORPHA:589821	Congenital-onset Steinert myotonic dystrophy		152
HP:0007010	HP:0007010	Poor fine motor coordination	0	DNAL4 CL E G H	10126	2955	ORPHA:238722	Familial congenital mirror movements	HP:0040282 - Frequent	2
HP:0007010	HP:0007010	Poor fine motor coordination	0	EZH2 CL E G H	2146	3527	OMIM:277590	Weaver syndrome		81
HP:0007010	HP:0007010	Poor fine motor coordination	0	FMR1 CL E G H	2332	3775	OMIM:300623	Fragile X tremor/ataxia syndrome		30
HP:0007010	HP:0007010	Poor fine motor coordination	0	FOCAD CL E G H	54914	23377	OMIM:619991			3
HP:0007010	HP:0007010	Poor fine motor coordination	0	FOXP2 CL E G H	93986	13875	ORPHA:209908	Childhood apraxia of speech	HP:0040282 - Frequent	143
HP:0007010	HP:0007010	Poor fine motor coordination	0	FXN CL E G H	2395	3951	ORPHA:95	Friedreich ataxia	HP:0040282 - Frequent	18
HP:0007010	HP:0007010	Poor fine motor coordination	0	GABRA1 CL E G H	2554	4075	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	134
HP:0007010	HP:0007010	Poor fine motor coordination	0	GABRD CL E G H	2563	4084	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	10
HP:0007010	HP:0007010	Poor fine motor coordination	0	GABRG2 CL E G H	2566	4087	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	139
HP:0007010	HP:0007010	Poor fine motor coordination	0	GABRG2 CL E G H	2566	4087	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	139
HP:0007010	HP:0007010	Poor fine motor coordination	0	GDAP1 CL E G H	54332	15968	ORPHA:99948	Charcot-Marie-Tooth disease type 4A		108
HP:0007010	HP:0007010	Poor fine motor coordination	0	GNB5 CL E G H	10681	4401	ORPHA:542306	GNB5-related intellectual disability-cardiac arrhythmia syndrome	HP:0040283 - Occasional	7
HP:0007010	HP:0007010	Poor fine motor coordination	0	GNB5 CL E G H	10681	4401	OMIM:617182	Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia	HP:0040284 - Very rare	7
HP:0007010	HP:0007010	Poor fine motor coordination	0	GNE CL E G H	10020	23657	OMIM:269921	SIALURIA		173
HP:0007010	HP:0007010	Poor fine motor coordination	0	HCN1 CL E G H	348980	4845	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	54
HP:0007010	HP:0007010	Poor fine motor coordination	0	HERC2 CL E G H	8924	4868	OMIM:176270	Prader-Willi syndrome		38
HP:0007010	HP:0007010	Poor fine motor coordination	0	HTT CL E G H	3064	4851	ORPHA:399	Huntington disease	HP:0040282 - Frequent	12
HP:0007010	HP:0007010	Poor fine motor coordination	0	IPW CL E G H	3653	6109	OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	MAGEL2 CL E G H	54551	6814	OMIM:176270	Prader-Willi syndrome		63
HP:0007010	HP:0007010	Poor fine motor coordination	0	MEG3 CL E G H	55384	14575	ORPHA:96184	Temple syndrome due to maternal uniparental disomy of chromosome 14	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	MEG3 CL E G H	55384	14575	ORPHA:254531	Temple syndrome due to paternal 14q32.2 hypomethylation	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	MEG3 CL E G H	55384	14575	ORPHA:254525	Temple syndrome due to paternal 14q32.2 microdeletion	HP:0040283 - Occasional	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	MFN2 CL E G H	9927	16877	ORPHA:99947	Autosomal dominant Charcot-Marie-Tooth disease type 2A2	HP:0040282 - Frequent	203
HP:0007010	HP:0007010	Poor fine motor coordination	0	MKRN3 CL E G H	7681	7114	OMIM:176270	Prader-Willi syndrome		5
HP:0007010	HP:0007010	Poor fine motor coordination	0	MKRN3-AS1 CL E G H	10108		OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	MMACHC CL E G H	25974	24525	ORPHA:79282	Methylmalonic acidemia with homocystinuria, type cblC	HP:0040283 - Occasional	101
HP:0007010	HP:0007010	Poor fine motor coordination	0	MTRFR CL E G H	91574	26784	ORPHA:320375	Autosomal recessive spastic paraplegia type 55	HP:0040282 - Frequent
HP:0007010	HP:0007010	Poor fine motor coordination	0	NPAP1 CL E G H	23742	1190	OMIM:176270	Prader-Willi syndrome		1
HP:0007010	HP:0007010	Poor fine motor coordination	0	NTN1 CL E G H	9423	8029	ORPHA:238722	Familial congenital mirror movements	HP:0040282 - Frequent
HP:0007010	HP:0007010	Poor fine motor coordination	0	PCDH19 CL E G H	57526	14270	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	225
HP:0007010	HP:0007010	Poor fine motor coordination	0	PDHX CL E G H	8050	21350	OMIM:245349	Pyruvate dehydrogenase e3-binding protein deficiency	.	98
HP:0007010	HP:0007010	Poor fine motor coordination	0	PIEZO2 CL E G H	63895	26270	OMIM:617146	Arthrogryposis, distal, with impaired proprioception and touch	.	77
HP:0007010	HP:0007010	Poor fine motor coordination	0	PPP2R2B CL E G H	5521	9305	ORPHA:98762	Spinocerebellar ataxia type 12	HP:0040283 - Occasional	5
HP:0007010	HP:0007010	Poor fine motor coordination	0	PRNP CL E G H	5621	9449	ORPHA:157941	Huntington disease-like 1	HP:0040283 - Occasional	69
HP:0007010	HP:0007010	Poor fine motor coordination	0	PWAR1 CL E G H	145624	30089	OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	PWRN1 CL E G H	791114	33235	OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	RAD51 CL E G H	5888	9817	ORPHA:238722	Familial congenital mirror movements	HP:0040282 - Frequent	9
HP:0007010	HP:0007010	Poor fine motor coordination	0	RAI1 CL E G H	10743	9834	ORPHA:1713	17p11.2 microduplication syndrome	HP:0040282 - Frequent	150
HP:0007010	HP:0007010	Poor fine motor coordination	0	RDH11 CL E G H	51109	17964	ORPHA:436245	Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome	HP:0040282 - Frequent	2
HP:0007010	HP:0007010	Poor fine motor coordination	0	RNU12 CL E G H	267010	19380	ORPHA:512260	Congenital cerebellar ataxia due to RNU12 mutation	HP:0040282 - Frequent
HP:0007010	HP:0007010	Poor fine motor coordination	0	RTL1 CL E G H	388015	14665	ORPHA:96184	Temple syndrome due to maternal uniparental disomy of chromosome 14	HP:0040283 - Occasional
HP:0007010	HP:0007010	Poor fine motor coordination	0	RTL1 CL E G H	388015	14665	ORPHA:254531	Temple syndrome due to paternal 14q32.2 hypomethylation	HP:0040283 - Occasional
HP:0007010	HP:0007010	Poor fine motor coordination	0	RTL1 CL E G H	388015	14665	ORPHA:254525	Temple syndrome due to paternal 14q32.2 microdeletion	HP:0040283 - Occasional
HP:0007010	HP:0007010	Poor fine motor coordination	0	SBF2 CL E G H	81846	2135	ORPHA:99956	Charcot-Marie-Tooth disease type 4B2		180
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN1A CL E G H	6323	10585	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	1053
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN1A CL E G H	6323	10585	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	1053
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN1B CL E G H	6324	10586	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	126
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN1B CL E G H	6324	10586	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	126
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN2A CL E G H	6326	10588	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	427
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN2A CL E G H	6326	10588	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	427
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN9A CL E G H	6335	10597	ORPHA:33069	Dravet syndrome	HP:0040283 - Occasional	318
HP:0007010	HP:0007010	Poor fine motor coordination	0	SCN9A CL E G H	6335	10597	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	318
HP:0007010	HP:0007010	Poor fine motor coordination	0	SLC2A3 CL E G H	6515	11007	ORPHA:399	Huntington disease	HP:0040282 - Frequent	1
HP:0007010	HP:0007010	Poor fine motor coordination	0	SLC30A10 CL E G H	55532	25355	ORPHA:309854	Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome	HP:0040283 - Occasional	42
HP:0007010	HP:0007010	Poor fine motor coordination	0	SLC30A10 CL E G H	55532	25355	OMIM:613280	Hypermanganesemia with dystonia 1	.	42
HP:0007010	HP:0007010	Poor fine motor coordination	0	SNORD115-1 CL E G H	338433	33020	OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	SNORD116-1 CL E G H	100033413	33067	OMIM:176270	Prader-Willi syndrome
HP:0007010	HP:0007010	Poor fine motor coordination	0	STX1B CL E G H	112755	18539	ORPHA:36387	Generalized epilepsy with febrile seizures-plus	HP:0040283 - Occasional	9
HP:0007010	HP:0007010	Poor fine motor coordination	0	THG1L CL E G H	54974	26053	OMIM:618800	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 28; SCAR28
HP:0007010	HP:0007010	Poor fine motor coordination	0	VCP CL E G H	7415	12666	ORPHA:435387	Autosomal dominant Charcot-Marie-Tooth disease type 2Y	HP:0040282 - Frequent	63
HP:0007010	HP:0007010	Poor fine motor coordination	0	ZEB2 CL E G H	9839	14881	ORPHA:261552	Mowat-Wilson syndrome due to a ZEB2 point mutation	HP:0040282 - Frequent	362
HP:0007010	HP:0007010	Poor fine motor coordination	0	ZEB2 CL E G H	9839	14881	ORPHA:261537	Mowat-Wilson syndrome due to monosomy 2q22	HP:0040282 - Frequent	362

Genes (58) :ADGRV1 ALMS1 C19ORF12 CXCR4 DARS2 DCC DLK1 DMPK DNAL4 EZH2 FMR1 FOCAD FOXP2 FXN GABRA1 GABRD GABRG2 GDAP1 GNB5 GNE HCN1 HERC2 HTT IPW MAGEL2 MEG3 MFN2 MKRN3 MKRN3-AS1 MMACHC MTRFR NPAP1 NTN1 PCDH19 PDHX PIEZO2 PPP2R2B PRNP PWAR1 PWRN1 RAD51 RAI1 RDH11 RNU12 RTL1 SBF2 SCN1A SCN1B SCN2A SCN9A SLC2A3 SLC30A10 SNORD115-1 SNORD116-1 STX1B THG1L VCP ZEB2

Diseases (39) :ORPHA:36387 ORPHA:64 ORPHA:320370 ORPHA:51636 ORPHA:137898 ORPHA:238722 ORPHA:96184 ORPHA:254531 ORPHA:254525 ORPHA:589821 OMIM:277590 OMIM:300623 OMIM:619991 ORPHA:209908 ORPHA:95 ORPHA:33069 ORPHA:99948 ORPHA:542306 OMIM:617182 OMIM:269921 OMIM:176270 ORPHA:399 ORPHA:99947 ORPHA:79282 ORPHA:320375 OMIM:245349 OMIM:617146 ORPHA:98762 ORPHA:157941 ORPHA:1713 ORPHA:436245 ORPHA:512260 ORPHA:99956 ORPHA:309854 OMIM:613280 OMIM:618800 ORPHA:435387 ORPHA:261552 ORPHA:261537

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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