Human Phenotype Ontology 
Grandparent Node:
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Decreased liver function (HP:0001410)help
Parent Node:
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Hepatic failure (HP:0001399)help
..Starting node
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Acute hepatic failure (HP:0006554)help
Term ID: 6554
Name: Acute hepatic failure
Synonym: Acute liver failure
Definition: Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.
Comments:
Reference: HP:0006554
Genes and Diseases:
 
       Child Nodes:
........expandFulminant hepatic failure (HP:0004448) help
................... HP:0004787 Fulminant hepatitis

 Sister Nodes: 
..expandChronic hepatic failure (HP:0100626) help
..expandFatal liver failure in infancy (HP:0006583) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006554HP:0006554Acute hepatic failure0ACAD9 CL E G H2897621497ORPHA:99901Acyl-CoA dehydrogenase 9 deficiencyHP:0040283 - Occasional98
HP:0006554HP:0006554Acute hepatic failure0ATP7B CL E G H540870ORPHA:905Wilson diseaseHP:0040281 - Very frequent315
HP:0006554HP:0006554Acute hepatic failure0ATP7B CL E G H540870OMIM:277900Wilson disease315
HP:0006554HP:0006554Acute hepatic failure0CACNA1S CL E G H7791397ORPHA:423Malignant hyperthermia of anesthesiaHP:0040283 - Occasional247
HP:0006554HP:0006554Acute hepatic failure0CALR CL E G H8111455ORPHA:131Budd-Chiari syndromeHP:0040283 - Occasional1
HP:0006554HP:0006554Acute hepatic failure0CYC1 CL E G H15372579OMIM:615453Mitochondrial complex III deficiency, nuclear type 6.12
HP:0006554HP:0006554Acute hepatic failure0EIF2AK3 CL E G H94513255ORPHA:1667Wolcott-Rallison syndromeHP:0040282 - Frequent65
HP:0006554HP:0006554Acute hepatic failure0F5 CL E G H21533542ORPHA:131Budd-Chiari syndromeHP:0040283 - Occasional159
HP:0006554HP:0006554Acute hepatic failure0FAH CL E G H21843579ORPHA:882Tyrosinemia type 1HP:0040283 - Occasional107
HP:0006554HP:0006554Acute hepatic failure0FAH CL E G H21843579OMIM:276700Tyrosinemia, type I.107
HP:0006554HP:0006554Acute hepatic failure0GFM1 CL E G H8547613780OMIM:609060Combined oxidative phosphorylation deficiency 185
HP:0006554HP:0006554Acute hepatic failure0GPR35 CL E G H28594492ORPHA:171Primary sclerosing cholangitisHP:0040284 - Very rare2
HP:0006554HP:0006554Acute hepatic failure0HADH CL E G H30334799OMIM:2315303-Hydroxyacyl-Coa dehydrogenase deficiency41
HP:0006554HP:0006554Acute hepatic failure0HADH CL E G H30334799ORPHA:71212Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiencyHP:0040284 - Very rare41
HP:0006554HP:0006554Acute hepatic failure0HLA-B CL E G H31064932ORPHA:36426Stevens-Johnson syndromeHP:0040283 - Occasional4
HP:0006554HP:0006554Acute hepatic failure0IKZF1 CL E G H1032013176ORPHA:36426Stevens-Johnson syndromeHP:0040283 - Occasional8
HP:0006554HP:0006554Acute hepatic failure0IL18BP CL E G H100685987OMIM:618549HEPATITIS, FULMINANT VIRAL, SUSCEPTIBILITY TO; FVH
HP:0006554HP:0006554Acute hepatic failure0ITCH CL E G H8373713890ORPHA:228426Syndromic multisystem autoimmune disease due to Itch deficiencyHP:0040283 - Occasional3
HP:0006554HP:0006554Acute hepatic failure0JAK2 CL E G H37176192ORPHA:131Budd-Chiari syndromeHP:0040283 - Occasional57
HP:0006554HP:0006554Acute hepatic failure0KRT18 CL E G H38756430OMIM:215600Cirrhosis, familial19
HP:0006554HP:0006554Acute hepatic failure0LARS1 CL E G H515206512OMIM:615438Infantile liver failure syndrome 1
HP:0006554HP:0006554Acute hepatic failure0LIPA CL E G H39886617OMIM:278000Lysosomal acid lipase deficiency73
HP:0006554HP:0006554Acute hepatic failure0MEFV CL E G H42106998ORPHA:342Familial Mediterranean feverHP:0040283 - Occasional281
HP:0006554HP:0006554Acute hepatic failure0MPV17 CL E G H43587224OMIM:256810Navajo neurohepatopathy.56
HP:0006554HP:0006554Acute hepatic failure0MST1 CL E G H44857380ORPHA:171Primary sclerosing cholangitisHP:0040284 - Very rare1
HP:0006554HP:0006554Acute hepatic failure0NBAS CL E G H5159415625OMIM:616483INFANTILE LIVER FAILURE SYNDROME 2; ILFS225
HP:0006554HP:0006554Acute hepatic failure0PORCN CL E G H6484017652ORPHA:2092Focal dermal hypoplasiaHP:0040283 - Occasional20
HP:0006554HP:0006554Acute hepatic failure0RINT1 CL E G H6056121876OMIM:618641INFANTILE LIVER FAILURE SYNDROME 3; ILFS399
HP:0006554HP:0006554Acute hepatic failure0RYR1 CL E G H626110483ORPHA:423Malignant hyperthermia of anesthesiaHP:0040283 - Occasional1200
HP:0006554HP:0006554Acute hepatic failure0SCYL1 CL E G H5741014372ORPHA:466794Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndromeHP:0040282 - Frequent5
HP:0006554HP:0006554Acute hepatic failure0SEMA4D CL E G H1050710732ORPHA:171Primary sclerosing cholangitisHP:0040284 - Very rare
HP:0006554HP:0006554Acute hepatic failure0SH2D1A CL E G H406810820OMIM:308240Lymphoproliferative syndrome, X-linked, 137
HP:0006554HP:0006554Acute hepatic failure0TCF4 CL E G H692511634ORPHA:171Primary sclerosing cholangitisHP:0040284 - Very rare241
HP:0006554HP:0006554Acute hepatic failure0TRMU CL E G H5568725481OMIM:613070Liver failure, infantile, transient.101
HP:0006554HP:0006554Acute hepatic failure0XIAP CL E G H331592OMIM:308240Lymphoproliferative syndrome, X-linked, 181
HP:0006554HP:0006554Acute hepatic failure0ZNFX1 CL E G H5716929271OMIM:619644IMMUNODEFICIENCY 91 AND HYPERINFLAMMATION; IMD91
HP:0006554HP:0004448Fulminant hepatic failure1GFM1 CL E G H8547613780OMIM:609060Combined oxidative phosphorylation deficiency 185
HP:0006554HP:0004448Fulminant hepatic failure1HADH CL E G H30334799OMIM:2315303-Hydroxyacyl-Coa dehydrogenase deficiency.41
HP:0006554HP:0004448Fulminant hepatic failure1IL18BP CL E G H100685987OMIM:618549HEPATITIS, FULMINANT VIRAL, SUSCEPTIBILITY TO; FVH
HP:0006554HP:0004448Fulminant hepatic failure1KRT18 CL E G H38756430OMIM:215600Cirrhosis, familial19
HP:0006554HP:0004448Fulminant hepatic failure1SH2D1A CL E G H406810820OMIM:308240Lymphoproliferative syndrome, X-linked, 137
HP:0006554HP:0004448Fulminant hepatic failure1XIAP CL E G H331592OMIM:308240Lymphoproliferative syndrome, X-linked, 181
HP:0006554HP:0004787Fulminant hepatitis2IL18BP CL E G H100685987OMIM:618549HEPATITIS, FULMINANT VIRAL, SUSCEPTIBILITY TO; FVH
HP:0006554HP:0004787Fulminant hepatitis2KRT18 CL E G H38756430OMIM:215600Cirrhosis, familial19
HP:0006554HP:0004787Fulminant hepatitis2SH2D1A CL E G H406810820OMIM:308240Lymphoproliferative syndrome, X-linked, 137
HP:0006554HP:0004787Fulminant hepatitis2XIAP CL E G H331592OMIM:308240Lymphoproliferative syndrome, X-linked, 181


Genes (33) :ACAD9 ATP7B CACNA1S CALR CYC1 EIF2AK3 F5 FAH GFM1 GPR35 HADH HLA-B IKZF1 IL18BP ITCH JAK2 KRT18 LARS1 LIPA MEFV MPV17 MST1 NBAS PORCN RINT1 RYR1 SCYL1 SEMA4D SH2D1A TCF4 TRMU XIAP ZNFX1

Diseases (28) :ORPHA:99901 ORPHA:905 OMIM:277900 ORPHA:423 ORPHA:131 OMIM:615453 ORPHA:1667 ORPHA:882 OMIM:276700 OMIM:609060 ORPHA:171 OMIM:231530 ORPHA:71212 ORPHA:36426 OMIM:618549 ORPHA:228426 OMIM:215600 OMIM:615438 OMIM:278000 ORPHA:342 OMIM:256810 OMIM:616483 ORPHA:2092 OMIM:618641 ORPHA:466794 OMIM:308240 OMIM:613070 OMIM:619644
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.