Human Phenotype Ontology 
Grandparent Node:
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Abnormality of blood and blood-forming tissues (HP:0001871)help
Grandparent Node:
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Neoplasm by anatomical site (HP:0011793)help
Parent Node:
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Hematological neoplasm (HP:0004377)help
..Starting node
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Lymphoproliferative disorder (HP:0005523)help
Term ID: 5523
Name: Lymphoproliferative disorder
Synonym: Lymphoproliferative disorders
Definition:
Comments:
Reference: HP:0005523
Genes and Diseases:
 
       Child Nodes:
........expandMonoclonal immunoglobulin M proteinemia (HP:0005508) help

 Sister Nodes: 
..expandLeukemia (HP:0001909) help
..expandLymphoma (HP:0002665) help
..expandMalignant eosinophil proliferation (HP:0006782) help
..expandMultiple myeloma (HP:0006775) help
..expandMyelodysplasia (HP:0002863) help
..expandPlasmacytoma (HP:0011857) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005523HP:0005523Lymphoproliferative disorder0ADA2 CL E G H518161839OMIM:615688Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome22
HP:0005523HP:0005523Lymphoproliferative disorder0CD27 CL E G H93911922OMIM:615122Lymphoproliferative syndrome 24
HP:0005523HP:0005523Lymphoproliferative disorder0CD70 CL E G H97011937OMIM:618261LYMPHOPROLIFERATIVE SYNDROME 3; LPFS3
HP:0005523HP:0005523Lymphoproliferative disorder0CTPS1 CL E G H15032519OMIM:615897IMMUNODEFICIENCY 24; IMD242
HP:0005523HP:0005523Lymphoproliferative disorder0IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiencyHP:0040284 - Very rare48
HP:0005523HP:0005523Lymphoproliferative disorder0ITK CL E G H37026171OMIM:613011LYMPHOPROLIFERATIVE SYNDROME 1; LPFS151
HP:0005523HP:0005523Lymphoproliferative disorder0KRAS CL E G H38456407OMIM:614470RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic.196
HP:0005523HP:0005523Lymphoproliferative disorder0LRBA CL E G H9871742OMIM:614700IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY; CVID845
HP:0005523HP:0005523Lymphoproliferative disorder0MAGT1 CL E G H8406128880OMIM:300853IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN17
HP:0005523HP:0005523Lymphoproliferative disorder0MCM4 CL E G H41736947OMIM:609981Immunodeficiency 54.69
HP:0005523HP:0005523Lymphoproliferative disorder0MYD88 CL E G H46157562OMIM:153600Macroglobulinemia, Waldenstrom, somatic9
HP:0005523HP:0005523Lymphoproliferative disorder0MYD88 CL E G H46157562ORPHA:33226Waldenström macroglobulinemia9
HP:0005523HP:0005523Lymphoproliferative disorder0NRAS CL E G H48937989OMIM:614470RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic.102
HP:0005523HP:0005523Lymphoproliferative disorder0PRKCD CL E G H55809399OMIM:615559AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS310
HP:0005523HP:0005523Lymphoproliferative disorder0SMARCAL1 CL E G H5048511102ORPHA:1830Schimke immuno-osseous dysplasiaHP:0040284 - Very rare74
HP:0005523HP:0005523Lymphoproliferative disorder0WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome65
HP:0005523HP:0005523Lymphoproliferative disorder0ZAP70 CL E G H753512858ORPHA:911Combined immunodeficiency due to ZAP70 deficiencyHP:0040284 - Very rare46
HP:0005523HP:0005508Monoclonal immunoglobulin M proteinemia1MYD88 CL E G H46157562OMIM:153600Macroglobulinemia, Waldenstrom, somatic.9
HP:0005523HP:0005508Monoclonal immunoglobulin M proteinemia1MYD88 CL E G H46157562ORPHA:33226Waldenström macroglobulinemiaHP:0040281 - Very frequent9


Genes (16) :ADA2 CD27 CD70 CTPS1 IL2RG ITK KRAS LRBA MAGT1 MCM4 MYD88 NRAS PRKCD SMARCAL1 WAS ZAP70

Diseases (16) :OMIM:615688 OMIM:615122 OMIM:618261 OMIM:615897 ORPHA:276 OMIM:613011 OMIM:614470 OMIM:614700 OMIM:300853 OMIM:609981 OMIM:153600 ORPHA:33226 OMIM:615559 ORPHA:1830 OMIM:301000 ORPHA:911
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.