Human Phenotype Ontology 
Grandparent Node:
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Abnormality of immune system physiology (HP:0010978)help
Parent Node:
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Opportunistic infection (HP:0031690)help
Parent Node:
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Recurrent infections (HP:0002719)help
..Starting node
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Recurrent opportunistic infections (HP:0005390)help
Term ID: 5390
Name: Recurrent opportunistic infections
Synonym: Frequent opportunistic infections
Definition: Increased susceptibility to opportunistic infections, as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system.
Comments:
Reference: HP:0005390
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandFailure to thrive secondary to recurrent infections (HP:0008866) help
..expandRecurrent abscess formation (HP:0002722) help
..expandRecurrent bacterial infections (HP:0002718) help
..expandRecurrent ear infections (HP:0410018) help
..expandRecurrent fungal infections (HP:0002841) help
..expandRecurrent infection of the gastrointestinal tract (HP:0004798) help
..expandRecurrent infections in infancy and early childhood (HP:0005437) help
..expandRecurrent infections of the middle ear (HP:0040268) help
..expandRecurrent otitis media (HP:0000403) help
..expandRecurrent parasitic infections (HP:0030885) help
..expandRecurrent protozoan infections (HP:0005386) help
..expandRecurrent respiratory infections (HP:0002205) help
..expandRecurrent urinary tract infections (HP:0000010) help
..expandRecurrent viral infections (HP:0004429) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005390HP:0005390Recurrent opportunistic infections0ADA CL E G H100186ORPHA:277Severe combined immunodeficiency due to adenosine deaminase deficiencyHP:0040282 - Frequent75
HP:0005390HP:0005390Recurrent opportunistic infections0DCLRE1C CL E G H6442117642ORPHA:275Severe combined immunodeficiency due to DCLRE1C deficiencyHP:0040282 - Frequent94
HP:0005390HP:0005390Recurrent opportunistic infections0IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiencyHP:0040282 - Frequent48
HP:0005390HP:0005390Recurrent opportunistic infections0IL7R CL E G H35756024OMIM:608971Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive.94
HP:0005390HP:0005390Recurrent opportunistic infections0JAK3 CL E G H37186193ORPHA:35078T-B+ severe combined immunodeficiency due to JAK3 deficiencyHP:0040282 - Frequent140
HP:0005390HP:0005390Recurrent opportunistic infections0NHP2 CL E G H5565114377OMIM:613987Dyskeratosis congenita, autosomal recessive, 227
HP:0005390HP:0005390Recurrent opportunistic infections0PNP CL E G H48607892OMIM:613179Immunodeficiency due to purine nucleoside phosphorylase deficiency.52
HP:0005390HP:0005390Recurrent opportunistic infections0RAG1 CL E G H58969831OMIM:601457Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive.127
HP:0005390HP:0005390Recurrent opportunistic infections0RAG2 CL E G H58979832OMIM:601457Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive.50
HP:0005390HP:0005390Recurrent opportunistic infections0ZAP70 CL E G H753512858ORPHA:911Combined immunodeficiency due to ZAP70 deficiencyHP:0040281 - Very frequent46


Genes (10) :ADA DCLRE1C IL2RG IL7R JAK3 NHP2 PNP RAG1 RAG2 ZAP70

Diseases (9) :ORPHA:277 ORPHA:275 ORPHA:276 OMIM:608971 ORPHA:35078 OMIM:613987 OMIM:613179 OMIM:601457 ORPHA:911
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.