Human Phenotype
Ontology
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Grandparent Node: Clinical course (HP:0031797) | Parent Node: Temporal pattern (HP:0011008) | ..Starting node ..Insidious onset (HP:0003587)
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Term ID: |
3587 |
Name: |
Insidious onset |
Synonym: |
Gradual onset |
Definition: |
Gradual, very slow onset of disease manifestations. |
Comments: |
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Reference: |
HP:0003587 |
Genes and Diseases: | | Child Nodes: | Sister Nodes: | ..Acute (HP:0011009)
| ..Chronic (HP:0011010)
| ..Diurnal (HP:0025302)
| ..Migratory (HP:0025279)
| ..Nocturnal (HP:0025301)
| ..Prolonged (HP:0025297)
| ..Recurrent (HP:0031796)
| ..Subacute (HP:0011011)
| ..Transient (HP:0025153)
| Input | HPO ID | HPO term | Distance | Gene | Gene id entrez | HGNC ID | DiseaseId | DiseaseName | Frequency | Onset | HGMD variants | ClinVar variants |
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HPO disease - gene - phenotype typical associations: | HPO disease - gene - phenotype less frequent non-typical associations: | HP:0003587 | HP:0003587 | Insidious onset | 0 | ADH1C CL E G H | 126 | 251 | OMIM:168600 | Parkinson disease, late-onset | . | | | 4 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | ATL1 CL E G H | 51062 | 11231 | OMIM:182600 | Spastic paraplegia 3, autosomal dominant | . | | | 71 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | ATXN2 CL E G H | 6311 | 10555 | OMIM:168600 | Parkinson disease, late-onset | . | | | 11 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | ATXN8OS CL E G H | 6315 | 10561 | OMIM:168600 | Parkinson disease, late-onset | . | | | 1 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | EIF4G1 CL E G H | 1981 | 3296 | OMIM:614251 | Parkinson disease 18 | . | | | 2 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | GBA1 CL E G H | 2629 | 4177 | OMIM:168600 | Parkinson disease, late-onset | . | | | | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | GLUD2 CL E G H | 2747 | 4336 | OMIM:168600 | Parkinson disease, late-onset | . | | | 1 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | MAPT CL E G H | 4137 | 6893 | OMIM:168600 | Parkinson disease, late-onset | . | | | 140 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | MPZ CL E G H | 4359 | 7225 | OMIM:118200 | Charcot-Marie-Tooth disease, demyelinating, type 1B | . | | | 134 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | NIPA1 CL E G H | 123606 | 17043 | OMIM:600363 | Spastic paraplegia 6, autosomal dominant | . | | | 117 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | NR4A2 CL E G H | 4929 | 7981 | OMIM:168600 | Parkinson disease, late-onset | . | | | 27 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | OPA1 CL E G H | 4976 | 8140 | OMIM:165500 | Optic atrophy 1 | . | | | 214 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | PMP22 CL E G H | 5376 | 9118 | OMIM:118220 | Charcot-Marie-Tooth disease, demyelinating, type 1A | . | | | 79 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | SNCA CL E G H | 6622 | 11138 | OMIM:168601 | Parkinson disease 1, autosomal dominant | . | | | 65 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | SNCAIP CL E G H | 9627 | 11139 | OMIM:168600 | Parkinson disease, late-onset | . | | | 35 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | SPAST CL E G H | 6683 | 11233 | OMIM:182601 | Spastic paraplegia 4, autosomal dominant | . | | | 208 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | TBP CL E G H | 6908 | 11588 | OMIM:168600 | Parkinson disease, late-onset | . | | | 7 | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | TRNT CL E G H | 4576 | 7499 | OMIM:168600 | Parkinson disease, late-onset | . | | | | | | HP:0003587 | HP:0003587 | Insidious onset | 0 | WASHC5 CL E G H | 9897 | 28984 | OMIM:603563 | Spastic paraplegia 8, autosomal dominant | . | | | 83 | | |
Genes (19) :ADH1C ATL1 ATXN2 ATXN8OS EIF4G1 GBA1 GLUD2 MAPT MPZ NIPA1 NR4A2 OPA1 PMP22 SNCA SNCAIP SPAST TBP TRNT WASHC5
Diseases (10) :OMIM:168600 OMIM:182600 OMIM:614251 OMIM:118200 OMIM:600363 OMIM:165500 OMIM:118220 OMIM:168601 OMIM:182601 OMIM:603563 |
Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.
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